Details for: CL0000909

Cell ID: CL0000909

Cell Name: CD8-positive, alpha-beta memory T cell

Marker Score Threshold: 849
(Derived using integrated single-cell and genomic data)

Description: A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell.

Synonyms: CD8-positive, alpha-beta memory T lymphocyte, CD8-positive, alpha-beta memory T-cell, CD8-positive, alpha-beta memory T-lymphocyte, T.8Mem.Sp

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 9.39
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.94
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.92
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.9
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.64
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.37
    Ensembl ID: ENSG00000075624
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 3.89
    Ensembl ID: ENSG00000104964
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.68
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.63
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 3.45
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.45
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.44
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.34
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.29
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.27
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 3.18
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 3.16
    Ensembl ID: ENSG00000241837
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.98
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.92
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.7
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.59
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.5
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.48
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.44
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.37
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.31
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.19
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.07
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.05
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.02
    Ensembl ID: ENSG00000135046
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 2.02
    Ensembl ID: ENSG00000173020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.96
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.84
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.83
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.82
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.74
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.73
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.67
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.66
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.63
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.62
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.62
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.62
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.62
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.62
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.61
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.59
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.58
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.53
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.53
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.53
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.5
    Ensembl ID: ENSG00000089820
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.4
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.4
    Ensembl ID: ENSG00000197043
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.38
    Ensembl ID: ENSG00000142188
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.33
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.31
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.31
    Ensembl ID: ENSG00000162909
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198356
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.29
    Ensembl ID: ENSG00000108561
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143799
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.22
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.21
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.18
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.16
    Ensembl ID: ENSG00000164615
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.14
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.14
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.14
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.13
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.12
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.1
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.09
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149311
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.07
    Ensembl ID: ENSG00000184922
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.05
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.04
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.04
    Ensembl ID: ENSG00000035687
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.03
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.02
    Ensembl ID: ENSG00000023445
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.02
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1
    Ensembl ID: ENSG00000137845
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD8-positive**: This cell is a type of T cell that expresses the CD8 molecule on its surface, which is a marker for cytotoxic T cells. 2. **Alpha-beta**: This cell expresses alpha-beta T cell receptors (TCRs) on its surface, which are essential for recognizing and binding to specific antigens. 3. **Memory T cell**: This cell has undergone a process of differentiation and maturation to become a memory T cell, which is characterized by its ability to remember and respond to specific antigens. 4. **Genes**: The cell expresses several genes, including SLC25A6, CALM2, ATP5F1E, and ATP5MC2, which are involved in various cellular processes such as metabolism, transport, and signaling. 5. **Pathways/Ontology**: The cell is involved in several cellular processes, including apoptosis, cell signaling, and metabolism, and is part of several pathways such as the apoptotic process, adenylate cyclase signaling, and calcium-dependent signaling. **Clinical Significance** 1. **Viral infections**: CD8-positive, alpha-beta memory T cells play a crucial role in the defense against viral infections, particularly in the defense against HIV and influenza viruses. 2. **Autoimmune diseases**: Memory T cells can also contribute to autoimmune diseases, as they can recognize and respond to self-antigens. 3. **Cancer**: Memory T cells can also play a role in cancer, as they can recognize and respond to tumor antigens. 4. **Immunotherapy**: Understanding the function and behavior of memory T cells is essential for the development of immunotherapies, such as cancer vaccines and adoptive T cell therapy. In conclusion, the CD8-positive, alpha-beta memory T cell is a crucial component of the adaptive immune response, and its function and behavior are essential for understanding the immune response to viral infections, autoimmune diseases, and cancer.