Details for: CL0000915

Cell ID: CL0000915

Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell

Marker Score Threshold: 1416
(Derived using integrated single-cell and genomic data)

Description: An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative.

Synonyms: CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte, CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell, CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.31
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.3
    Ensembl ID: ENSG00000184009
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.3
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.27
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.26
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.19
    Ensembl ID: ENSG00000111348
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.18
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.17
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.15
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.15
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.14
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.9
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.8
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.73
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.67
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.66
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.6
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.57
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.57
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.52
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.52
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.5
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.46
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.39
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.38
    Ensembl ID: ENSG00000204472
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.38
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.31
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.23
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 2.23
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 2.22
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 2.21
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.16
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.16
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 2.12
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.09
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.08
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152495
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.94
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.94
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.92
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.9
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.89
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.86
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.85
    Ensembl ID: ENSG00000132965
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.82
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.79
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.77
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.75
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.72
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.71
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.7
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.68
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.65
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.59
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.58
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.58
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.51
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.5
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.49
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.49
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.49
    Ensembl ID: ENSG00000128272
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.45
    Ensembl ID: ENSG00000117054
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.37
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.36
    Ensembl ID: ENSG00000060971
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.35
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.32
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.31
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.29
    Ensembl ID: ENSG00000138363
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.28
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.28
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.2
    Ensembl ID: ENSG00000127837
  • Gene Symbol: CASP3 (ENSG00000164305)
    Fold Change: 1.2
    Ensembl ID: ENSG00000164305
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.18
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.17
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.16
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CCNC (ENSG00000112237)
    Fold Change: 1.15
    Ensembl ID: ENSG00000112237
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.15
    Ensembl ID: ENSG00000113328
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140299
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.14
    Ensembl ID: ENSG00000121410
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.14
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.11
    Ensembl ID: ENSG00000163399
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.11
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.11
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.09
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.04
    Ensembl ID: ENSG00000089820
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060982
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.01
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: N/A
    Ensembl ID: ENSG00000072110
Hovered Details

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Hovered Details

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**Key Characteristics** The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell has several key characteristics that distinguish it from other types of T cells: * Phenotype: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell * Location: Found in the columnar epithelium of the gastrointestinal tract * Memory phenotype: CD2-negative and CD5-negative * Function: Regulates cell-cell interactions, cell signaling, and immune responses * Gene expression: Actin cytoskeleton, adherens junctions interactions, apical junction complex, ATP binding, axon guidance, axonogenesis, etc. **Clinical Significance** The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell plays a crucial role in the regulation of immune responses and is involved in various diseases, including: * Inflammatory bowel disease (IBD): The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell is thought to play a role in the pathogenesis of IBD, particularly in the development of Crohn's disease. * Cancer: The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell is also involved in the development and progression of cancer, including colorectal cancer. * Autoimmune diseases: The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell is thought to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. * Infectious diseases: The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell is involved in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. In conclusion, the CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell is a unique type of T cell that plays a crucial role in the regulation of cell-cell interactions, cell signaling, and immune responses. Its dysregulation has been implicated in various diseases, including inflammatory bowel disease, cancer, autoimmune diseases, and infectious diseases.