Details for: CL0000934

Cell ID: CL0000934

Cell Name: CD4-positive, alpha-beta cytotoxic T cell

Marker Score Threshold: 878
(Derived using integrated single-cell and genomic data)

Description: A CD4-positive, alpha-beta T cell that has cytotoxic function.

Synonyms: CD4-positive, alpha-beta cytotoxic T lymphocyte, CD4-positive, alpha-beta cytotoxic T-cell, CD4-positive, alpha-beta cytotoxic T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.91
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.58
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.57
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.47
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.42
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.39
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.37
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.37
    Ensembl ID: ENSG00000133639
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 3.2
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.97
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.87
    Ensembl ID: ENSG00000077549
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.83
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.79
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.74
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.69
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.68
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.62
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.61
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.5
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.5
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.49
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.48
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.46
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.41
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 2.39
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.37
    Ensembl ID: ENSG00000184009
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.36
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 2.26
    Ensembl ID: ENSG00000013725
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.25
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198821
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.18
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.17
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.13
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.04
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 2.03
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.02
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.99
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.99
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110448
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.94
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.93
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.92
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.88
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.87
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.84
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.8
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.79
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.77
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.75
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.74
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.73
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.71
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.67
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.64
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.6
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.56
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.56
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.54
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.54
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.53
    Ensembl ID: ENSG00000110848
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.48
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.46
    Ensembl ID: ENSG00000130402
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.38
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.36
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 1.32
    Ensembl ID: ENSG00000167286
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.31
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.3
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.29
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.27
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.25
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.24
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.23
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.23
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.21
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.21
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.19
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: 1.18
    Ensembl ID: ENSG00000151651
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.16
    Ensembl ID: ENSG00000116824
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 1.15
    Ensembl ID: ENSG00000137752
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.15
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.14
    Ensembl ID: ENSG00000020633
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.07
    Ensembl ID: ENSG00000169252
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.06
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164615
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.01
    Ensembl ID: ENSG00000118971
Hovered Details

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Hovered Details

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**Key Characteristics** The CD4-positive, alpha-beta cytotoxic T cell has several key characteristics that enable it to perform its function: * **Cytotoxic function**: These cells are capable of killing infected cells or tumor cells through the release of cytotoxic granules and the expression of death ligands. * **Alpha-beta T cell receptor**: These cells express an alpha-beta T cell receptor, which recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on the surface of infected cells or tumor cells. * **CD4 marker**: These cells express the CD4 marker, which is a co-receptor that helps to facilitate the interaction between the T cell receptor and the MHC molecule. * **Cytoskeleton organization**: The cell's cytoskeleton is organized in a way that enables it to move and interact with its environment, including the release of cytotoxic granules and the expression of death ligands. * **Gene expression**: The cell's gene expression is regulated by a variety of mechanisms, including the activation of transcription factors and the regulation of gene expression through chromatin remodeling. **Clinical Significance** CD4-positive, alpha-beta cytotoxic T cells play a crucial role in the adaptive immune system, and their dysfunction or dysregulation can lead to a range of clinical disorders, including: * **Autoimmune diseases**: The loss of cytotoxic function in CD4-positive, alpha-beta T cells can lead to autoimmune diseases, such as rheumatoid arthritis and lupus. * **Cancer**: The dysfunction of CD4-positive, alpha-beta T cells can also contribute to the development of cancer, as these cells are unable to recognize and kill tumor cells. * **Infectious diseases**: The loss of cytotoxic function in CD4-positive, alpha-beta T cells can also make individuals more susceptible to infectious diseases, such as HIV and tuberculosis. * **Immunodeficiency disorders**: The dysfunction of CD4-positive, alpha-beta T cells can also lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). Overall, CD4-positive, alpha-beta cytotoxic T cells are a critical component of the adaptive immune system, and their function is essential for maintaining immune homeostasis and preventing disease.