Details for: CL0000937

Cell ID: CL0000937

Cell Name: pre-natural killer cell

Marker Score Threshold: 532
(Derived using integrated single-cell and genomic data)

Description: Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins.

Synonyms: pre-NK cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.2
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.07
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.07
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.05
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.05
    Ensembl ID: ENSG00000087086
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.02
    Ensembl ID: ENSG00000132475
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.01
    Ensembl ID: ENSG00000149806
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 1.95
    Ensembl ID: ENSG00000122566
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 1.95
    Ensembl ID: ENSG00000111640
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.86
    Ensembl ID: ENSG00000108654
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.81
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.8
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.78
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.78
    Ensembl ID: ENSG00000167658
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 1.77
    Ensembl ID: ENSG00000189403
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.77
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.74
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.72
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.65
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.65
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.57
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 1.57
    Ensembl ID: ENSG00000206503
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.54
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.54
    Ensembl ID: ENSG00000124172
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 1.54
    Ensembl ID: ENSG00000169567
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.54
    Ensembl ID: ENSG00000156976
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.53
    Ensembl ID: ENSG00000114942
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.52
    Ensembl ID: ENSG00000133639
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 1.52
    Ensembl ID: ENSG00000092199
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165119
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 1.51
    Ensembl ID: ENSG00000087460
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 1.48
    Ensembl ID: ENSG00000204525
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 1.46
    Ensembl ID: ENSG00000234745
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.45
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.43
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.43
    Ensembl ID: ENSG00000112695
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 1.42
    Ensembl ID: ENSG00000135486
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 1.42
    Ensembl ID: ENSG00000153187
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 1.41
    Ensembl ID: ENSG00000163041
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.39
    Ensembl ID: ENSG00000135940
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 1.39
    Ensembl ID: ENSG00000205581
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.36
    Ensembl ID: ENSG00000089280
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.35
    Ensembl ID: ENSG00000135404
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 1.34
    Ensembl ID: ENSG00000167468
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.33
    Ensembl ID: ENSG00000067082
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.33
    Ensembl ID: ENSG00000111775
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.33
    Ensembl ID: ENSG00000110321
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.32
    Ensembl ID: ENSG00000077549
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143774
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 1.31
    Ensembl ID: ENSG00000169045
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.31
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.31
    Ensembl ID: ENSG00000074800
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 1.29
    Ensembl ID: ENSG00000204592
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.27
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.27
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.27
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122545
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 1.26
    Ensembl ID: ENSG00000084207
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 1.26
    Ensembl ID: ENSG00000170345
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143761
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 1.24
    Ensembl ID: ENSG00000167004
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 1.24
    Ensembl ID: ENSG00000164032
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.21
    Ensembl ID: ENSG00000154723
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.21
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.2
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.19
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.19
    Ensembl ID: ENSG00000185650
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198830
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.18
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.18
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.17
    Ensembl ID: ENSG00000134825
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100664
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.17
    Ensembl ID: ENSG00000005022
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.14
    Ensembl ID: ENSG00000131174
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.13
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.13
    Ensembl ID: ENSG00000155368
  • Gene Symbol: DNAJA1 (ENSG00000086061)
    Fold Change: 1.12
    Ensembl ID: ENSG00000086061
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.1
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127022
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.08
    Ensembl ID: ENSG00000215301
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.08
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.07
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.07
    Ensembl ID: ENSG00000085224
  • Gene Symbol: HNRNPF (ENSG00000169813)
    Fold Change: 1.06
    Ensembl ID: ENSG00000169813
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.06
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.05
    Ensembl ID: ENSG00000019582
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.05
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100632
  • Gene Symbol: HNRNPD (ENSG00000138668)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138668
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: GDI2 (ENSG00000057608)
    Fold Change: 1.03
    Ensembl ID: ENSG00000057608
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.03
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.02
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143420
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1
    Ensembl ID: ENSG00000196419
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: N/A
    Ensembl ID: ENSG00000144674
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The pre-NK cell is characterized by its: 1. **Positive expression of CD122, CD34, and CD117**: These surface markers are typically associated with hematopoietic stem cells and progenitor cells, but their expression in pre-NK cells suggests a commitment to the natural killer cell lineage. 2. **Lack of natural killer receptor proteins**: This characteristic distinguishes pre-NK cells from mature natural killer cells, which express specific natural killer receptor proteins. 3. **Actin cytoskeleton organization**: The pre-NK cell's actin cytoskeleton is involved in various cellular processes, including cell migration, adhesion, and phagocytosis. 4. **Apoptosis regulation**: Pre-NK cells are capable of regulating apoptosis, which is essential for maintaining immune homeostasis. 5. **Antigen processing and presentation**: Pre-NK cells can process and present antigens to T cells, which is an important function in the regulation of the immune response. **Clinical Significance** The pre-NK cell plays a crucial role in the development of natural killer cells, which are essential for the immune system's function. Dysregulation of pre-NK cell development can lead to various immune-related disorders, including: 1. **Immunodeficiency**: Impaired natural killer cell function can lead to increased susceptibility to infections and autoimmune diseases. 2. **Cancer**: Altered natural killer cell function can contribute to tumorigenesis and metastasis. 3. **Autoimmune diseases**: Dysregulation of pre-NK cell development can lead to autoimmune diseases, such as rheumatoid arthritis and lupus. Understanding the pre-NK cell's function and regulation is essential for developing novel therapeutic strategies for immune-related disorders. This includes the development of immunotherapies that target pre-NK cell development and function, as well as strategies to modulate the immune response and prevent autoimmune diseases. **Pathways and Ontology** The pre-NK cell is involved in various cellular processes, including: 1. **Actin cytoskeleton organization**: The pre-NK cell's actin cytoskeleton is involved in cell migration, adhesion, and phagocytosis. 2. **Apoptosis regulation**: Pre-NK cells are capable of regulating apoptosis, which is essential for maintaining immune homeostasis. 3. **Antigen processing and presentation**: Pre-NK cells can process and present antigens to T cells, which is an important function in the regulation of the immune response. 4. **Immune system regulation**: Pre-NK cells play a crucial role in regulating the immune response, including the activation of T cells and the production of cytokines. The pre-NK cell is also involved in various signaling pathways, including: 1. **MAPK signaling**: The pre-NK cell's MAPK signaling pathway is involved in the regulation of cell proliferation, differentiation, and survival. 2. **Raf/MEK/ERK signaling**: The pre-NK cell's Raf/MEK/ERK signaling pathway is involved in the regulation of cell proliferation, differentiation, and survival. 3. **JAK/STAT signaling**: The pre-NK cell's JAK/STAT signaling pathway is involved in the regulation of cytokine signaling and immune response. Overall, the pre-NK cell is a crucial component of the immune system, and its understanding is essential for developing novel therapeutic strategies for immune-related disorders.