Details for: CL0000938

Cell ID: CL0000938

Cell Name: CD16-negative, CD56-bright natural killer cell, human

Marker Score Threshold: 819
(Derived using integrated single-cell and genomic data)

Description: NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic.

Synonyms: CD16-CD56bright NK cell, CD16-negative, CD56-bright NK cell, CD56-bright cytokine secreting NK cell, CD56-bright cytokine secreting natural killer cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.07
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.47
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.45
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.39
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.2
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.18
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.06
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.03
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.99
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.89
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.84
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.61
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.6
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.55
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.52
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.48
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.46
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.4
    Ensembl ID: ENSG00000185883
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.4
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.39
    Ensembl ID: ENSG00000143933
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.34
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.3
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.28
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.27
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.24
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.17
    Ensembl ID: ENSG00000135404
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.08
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.98
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.96
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.95
    Ensembl ID: ENSG00000130303
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.9
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.86
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.84
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.82
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.81
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.79
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.77
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.76
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.75
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.75
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.74
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.73
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.72
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.71
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.69
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.68
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.68
    Ensembl ID: ENSG00000123146
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.67
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.66
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.62
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.58
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.58
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.54
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.53
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.51
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.49
    Ensembl ID: ENSG00000168374
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.43
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.42
    Ensembl ID: ENSG00000160710
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.39
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.36
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.35
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.34
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.31
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.28
    Ensembl ID: ENSG00000136717
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.26
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.26
    Ensembl ID: ENSG00000110848
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.23
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.22
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.21
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.17
    Ensembl ID: ENSG00000137845
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.17
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.15
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.14
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.13
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 1.12
    Ensembl ID: ENSG00000136250
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.12
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.1
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.09
    Ensembl ID: ENSG00000116489
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.06
    Ensembl ID: ENSG00000020633
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.05
    Ensembl ID: ENSG00000221869
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.04
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CDKN2D (ENSG00000129355)
    Fold Change: 1.04
    Ensembl ID: ENSG00000129355
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.04
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.03
    Ensembl ID: ENSG00000070961
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD56-bright and CD16-negative phenotype**: These cells express high levels of CD56 and lack CD16, a characteristic that distinguishes them from other types of NK cells. 2. **IFN-γ secretion**: Unlike cytotoxic NK cells, CD16-negative, CD56-bright NK cells do not exhibit cytotoxic activity and instead secrete IFN-γ, a cytokine involved in immune responses. 3. **CD84 positivity**: These cells are also characterized by their expression of CD84, a marker that has been linked to the regulation of immune responses. 4. **Actin cytoskeleton organization**: The cytoskeleton of CD16-negative, CD56-bright NK cells is organized in a way that is distinct from that of other NK cells, which may be related to their unique functions. **Clinical Significance** 1. **Cancer immunotherapy**: CD16-negative, CD56-bright NK cells have been implicated in the regulation of cancer immune responses, and their role in cancer immunotherapy is an area of ongoing research. 2. **Viral infections**: These cells have been shown to play a crucial role in the innate immune response to viral infections, particularly in the context of HIV and other viruses. 3. **Autoimmune diseases**: The dysregulation of CD16-negative, CD56-bright NK cells has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Innate immunity**: The CD16-negative, CD56-bright NK cell plays a critical role in the innate immune system, particularly in the context of early responses to pathogens and tumor cells. **Genes and Pathways** 1. **ACTB**: The gene ACTB is associated with the cytoskeleton organization of CD16-negative, CD56-bright NK cells. 2. **B2M**: The gene B2M is involved in the regulation of immune responses, particularly in the context of antigen presentation and cytokine signaling. 3. **MHC class I**: The MHC class I molecule plays a crucial role in the regulation of immune responses, particularly in the context of antigen presentation and cytokine signaling. **Diseases and Disorders** 1. **Multiple sclerosis**: The dysregulation of CD16-negative, CD56-bright NK cells has been implicated in multiple sclerosis, a chronic autoimmune disease. 2. **Rheumatoid arthritis**: The dysregulation of CD16-negative, CD56-bright NK cells has also been implicated in rheumatoid arthritis, a chronic autoimmune disease. 3. **Cancer**: CD16-negative, CD56-bright NK cells have been implicated in the regulation of cancer immune responses, particularly in the context of cancer immunotherapy. In conclusion, the CD16-negative, CD56-bright NK cell is a unique subtype of NK cells that plays a critical role in the innate immune system, particularly in the context of cancer and viral infections. Further research is needed to fully understand the functions and dysregulation of this cell type in human diseases.