Details for: CL0000939

Cell ID: CL0000939

Cell Name: CD16-positive, CD56-dim natural killer cell, human

Marker Score Threshold: 774
(Derived using integrated single-cell and genomic data)

Description: A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production.

Synonyms: CD16+CD56+ NK cell, CD16-positive, CD56-dim NK cell, CD16-positive, CD56-low NK cell, CD16-positive, CD56-low natural killer cell, CD16-positive, CD56-positive NK cell, CD16-positive, CD56-positive natural killer cell, cytotoxic CD56-dim NK cell, cytotoxic CD56-dim natural killer cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.25
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.06
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.74
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.47
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.44
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.39
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.32
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.08
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.08
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.05
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.04
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.96
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.94
    Ensembl ID: ENSG00000019582
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.94
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.91
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.91
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.91
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.9
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.88
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.84
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.79
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.79
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.79
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.73
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.72
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.71
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.71
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.7
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.67
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.66
    Ensembl ID: ENSG00000111348
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.62
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.62
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.6
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.58
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.57
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.55
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.53
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.52
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.49
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.47
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.44
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.42
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.4
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.38
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.37
    Ensembl ID: ENSG00000135046
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.35
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.35
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130303
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.35
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.34
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.34
    Ensembl ID: ENSG00000112576
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.31
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.3
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.29
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.28
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.28
    Ensembl ID: ENSG00000165527
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.27
    Ensembl ID: ENSG00000183255
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.27
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.22
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.21
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.2
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.18
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.18
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.18
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.17
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.16
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.12
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.12
    Ensembl ID: ENSG00000126247
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.1
    Ensembl ID: ENSG00000155366
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.09
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.09
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.08
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.05
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.04
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177697
Hovered Details

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Hovered Details

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**Key Characteristics** * **Phenotype**: CD16-positive, CD56-dim * **Cytotoxicity**: Capable of inducing cell death in target cells * **Cytokine production**: Produces various cytokines, including interferon-gamma, which regulates immune responses * **Antigen presentation**: Involved in presenting antigens to T-cells through MHC class I molecules * **Immune system regulation**: Regulates immune responses through the production of cytokines and the modulation of immune cell function **Clinical Significance** * **Cancer immunotherapy**: NK cells have been used as a form of immunotherapy to treat various types of cancer, including leukemia and lymphoma * **Viral infections**: NK cells play a crucial role in defending against viral infections, such as HIV and influenza * **Autoimmune diseases**: NK cells have been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis * **Transplantation**: NK cells have been used to prevent graft rejection in organ transplantation * **Immunodeficiency**: Defects in NK cell function have been associated with immunodeficiency diseases, such as severe combined immunodeficiency (SCID) **Biological Processes** * **Antigen presentation**: NK cells present antigens to T-cells through MHC class I molecules * **Cytokine signaling**: NK cells produce cytokines, which regulate immune responses * **Immune system regulation**: NK cells modulate immune responses through the production of cytokines and the regulation of immune cell function * **Apoptosis**: NK cells induce apoptosis in target cells through the release of cytotoxins **Pathways and Ontology** * **Adaptive immune system**: NK cells are involved in the adaptive immune system, specifically in the regulation of T-cell responses * **Amyloid fiber formation**: NK cells are involved in the formation of amyloid fibers, which are associated with various diseases, including Alzheimer's disease * **Antigen processing-cross presentation**: NK cells process and present antigens to T-cells through MHC class I molecules * **Cytokine signaling in immune system**: NK cells produce cytokines, which regulate immune responses * **Innate immune system**: NK cells are a component of the innate immune system, which provides immediate defense against pathogens **Gene Expression and Regulation** * **Gene Symbol**: B2M, SLC25A6, ACTB * **Ensembl ID**: ENSG00000166710, ENSG00000169100, ENSG00000075624 * **Pathways**: Various pathways, including adaptive immune system, amyloid fiber formation, antigen presentation, cytokine signaling, and innate immune system. In conclusion, CD16-positive, CD56-dim natural killer cells are a critical component of the innate immune system, playing a key role in defending against viral infections, tumor cells, and other pathogens. Their ability to induce cell death, produce cytokines, and regulate immune responses makes them an essential part of the immune system.