Details for: CL0000956

Cell ID: CL0000956

Cell Name: pre-B-I cell

Marker Score Threshold: 255
(Derived using integrated single-cell and genomic data)

Description: A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein.

Synonyms: pre-BI cell, pro-B cell (Philadelphia nomenclature)

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.61
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.52
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.29
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.04
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.02
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.02
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2
    Ensembl ID: ENSG00000104894
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.95
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.91
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.91
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.87
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 1.87
    Ensembl ID: ENSG00000004468
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.86
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.83
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.81
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.8
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.77
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.75
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.73
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.71
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.69
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.66
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.65
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.64
    Ensembl ID: ENSG00000134825
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.64
    Ensembl ID: ENSG00000067560
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.63
    Ensembl ID: ENSG00000100300
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.62
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.61
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.6
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.59
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.56
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.54
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143933
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.52
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.5
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.48
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.48
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.48
    Ensembl ID: ENSG00000177455
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.48
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.46
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110987
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.45
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.44
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.44
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.44
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.42
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.41
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.41
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.38
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.37
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.37
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.37
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.33
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.32
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.3
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.28
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.28
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.28
    Ensembl ID: ENSG00000069849
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.27
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160710
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.26
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.26
    Ensembl ID: ENSG00000168374
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.24
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.24
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.23
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.21
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.21
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.2
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.19
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.19
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.17
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.16
    Ensembl ID: ENSG00000174437
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168675
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.13
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.11
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.09
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CD72 (ENSG00000137101)
    Fold Change: 1.09
    Ensembl ID: ENSG00000137101
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.06
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.04
    Ensembl ID: ENSG00000090013
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.04
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.03
    Ensembl ID: ENSG00000185883
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.02
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.01
    Ensembl ID: ENSG00000010671
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.01
    Ensembl ID: ENSG00000128595
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1
    Ensembl ID: ENSG00000101966
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Surface markers:** CD34, VpreB/Lambda 5/Mouse 14.1, TdT, Rag1, and Rag2. 2. **DNA rearrangement:** D-JH recombination, which involves the recombination of the D and J segments of the immunoglobulin heavy chain gene. 3. **Immunoglobulin expression:** Lack of immunoglobulin heavy chain protein expression. 4. **Cellular characteristics:** Immature B cell, precursor to mature B cells. 5. **Functional role:** Essential for the development of mature B cells and the production of antibodies. **Clinical Significance** 1. **Immunodeficiency:** Pre-B-I cells play a crucial role in the development of mature B cells, which are essential for the production of antibodies. Defects in pre-B-I cell development can lead to immunodeficiency disorders. 2. **Cancer:** Abnormalities in pre-B-I cell development have been associated with certain types of cancer, such as acute lymphoblastic leukemia (ALL). 3. **Autoimmunity:** Dysregulation of pre-B-I cell development can lead to autoimmune disorders, where the immune system produces antibodies against self-antigens. 4. **Vaccine development:** Understanding the development of pre-B-I cells is essential for the development of effective vaccines, as they play a crucial role in the production of antibodies in response to antigens. In conclusion, the pre-B-I cell is a critical component of the immune system, and its development is essential for the production of antibodies. Understanding the characteristics and clinical significance of pre-B-I cells is crucial for the development of effective vaccines and the treatment of immunodeficiency disorders.