Details for: CL0000979

Cell ID: CL0000979

Cell Name: IgG memory B cell

Marker Score Threshold: 602
(Derived using integrated single-cell and genomic data)

Description: An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface.

Synonyms: IgG memory B lymphocyte, IgG memory B-cell, IgG memory B-lymphocyte, memory IgG B cell, memory IgG B lymphocyte, memory IgG B-cell, memory IgG B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 3.18
    Ensembl ID: ENSG00000156738
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.09
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.08
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.06
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.05
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.97
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.97
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.95
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.88
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.77
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.76
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.7
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.61
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.56
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.5
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 2.48
    Ensembl ID: ENSG00000136573
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.47
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.45
    Ensembl ID: ENSG00000143761
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 2.44
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.43
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.42
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.34
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.3
    Ensembl ID: ENSG00000179218
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.26
    Ensembl ID: ENSG00000168421
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.22
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.13
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.13
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.1
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.08
    Ensembl ID: ENSG00000077549
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.07
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.04
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.04
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 2.01
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.99
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.97
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.89
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.84
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.83
    Ensembl ID: ENSG00000149311
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.81
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.75
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.74
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.74
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.7
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.69
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.64
    Ensembl ID: ENSG00000126247
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.63
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.6
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.6
    Ensembl ID: ENSG00000197043
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.59
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.58
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.58
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.56
    Ensembl ID: ENSG00000140299
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.56
    Ensembl ID: ENSG00000020633
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.53
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.52
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.52
    Ensembl ID: ENSG00000115307
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.51
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.51
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.49
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.48
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.48
    Ensembl ID: ENSG00000196954
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.47
    Ensembl ID: ENSG00000159461
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.44
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.44
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.43
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.38
    Ensembl ID: ENSG00000074370
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.37
    Ensembl ID: ENSG00000159199
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.35
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.32
    Ensembl ID: ENSG00000102575
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.29
    Ensembl ID: ENSG00000177455
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.28
    Ensembl ID: ENSG00000089820
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.28
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.27
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.25
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.25
    Ensembl ID: ENSG00000010671
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.19
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.18
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.17
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.17
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.15
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.14
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.12
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.11
    Ensembl ID: ENSG00000140379
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.09
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.08
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.06
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.03
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.02
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.02
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.02
    Ensembl ID: ENSG00000105221
Hovered Details

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Hovered Details

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**Key Characteristics** The IgG memory B cell is characterized by the following key features: 1. **Class-switched B cell**: IgG memory B cells have undergone class switching from IgM to IgG, allowing them to recognize and respond to a wider range of antigens. 2. **IgG expression**: These cells express IgG on their surface, enabling them to bind to and neutralize pathogens and other foreign substances. 3. **Memory cell**: IgG memory B cells are memory cells that have undergone clonal expansion and differentiation, allowing them to recognize and respond to specific antigens. 4. **Antigen presentation**: IgG memory B cells can present antigens to T cells, activating an immune response against pathogens and other foreign substances. 5. **Cell surface receptors**: These cells express cell surface receptors, such as MHC class II, that facilitate antigen presentation and recognition. **Clinical Significance** The IgG memory B cell plays a crucial role in the humoral immune response, providing long-term immunity against pathogens and other foreign substances. Clinical significance of IgG memory B cells includes: 1. **Immune response**: IgG memory B cells are essential for mounting an effective immune response against pathogens, such as bacteria, viruses, and other foreign substances. 2. **Autoimmune diseases**: Dysregulation of IgG memory B cells has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: IgG memory B cells can be involved in the development and progression of certain cancers, such as lymphoma and multiple myeloma. 4. **Vaccine development**: IgG memory B cells are a key target for vaccine development, as they provide long-term immunity against pathogens and other foreign substances. 5. **Immunodeficiency disorders**: Dysregulation of IgG memory B cells has been implicated in immunodeficiency disorders, such as HIV/AIDS and primary immunodeficiency diseases. In conclusion, the IgG memory B cell is a specialized class-switched B cell that plays a crucial role in the humoral immune response, providing long-term immunity against pathogens and other foreign substances. Understanding the characteristics and clinical significance of IgG memory B cells is essential for the development of effective vaccines and treatments for autoimmune diseases and immunodeficiency disorders.