Details for: CL0000980

Cell ID: CL0000980

Cell Name: plasmablast

Marker Score Threshold: 1330
(Derived using integrated single-cell and genomic data)

Description: An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative.

Synonyms: CD20-negative B cell, CD27-positive, CD38-positive, CD20-negative B cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.77
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.69
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.65
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.5
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.49
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.49
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.42
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.38
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.36
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.24
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.21
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.2
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.2
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.17
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.15
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.15
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.07
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.07
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.07
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.07
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.07
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.05
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.05
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.04
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.01
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.01
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.97
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.97
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.94
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.88
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.83
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.83
    Ensembl ID: ENSG00000130303
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.82
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143727
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.75
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.74
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.72
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.7
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.69
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.58
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.55
    Ensembl ID: ENSG00000100412
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.54
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.53
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.52
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.52
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.51
    Ensembl ID: ENSG00000160710
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.47
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.44
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.43
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BIRC5 (ENSG00000089685)
    Fold Change: 1.43
    Ensembl ID: ENSG00000089685
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.42
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.41
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.38
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.38
    Ensembl ID: ENSG00000162909
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165272
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.34
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.34
    Ensembl ID: ENSG00000071553
  • Gene Symbol: BUB1 (ENSG00000169679)
    Fold Change: 1.33
    Ensembl ID: ENSG00000169679
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.32
    Ensembl ID: ENSG00000156110
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.31
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.3
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.29
    Ensembl ID: ENSG00000204574
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.28
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.28
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.27
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.27
    Ensembl ID: ENSG00000239900
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.26
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.25
    Ensembl ID: ENSG00000126247
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.23
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.2
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.19
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.18
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.17
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.17
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138363
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.14
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.13
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.12
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.12
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 1.07
    Ensembl ID: ENSG00000248098
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.07
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 1.04
    Ensembl ID: ENSG00000236824
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142188
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.02
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100280
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.01
    Ensembl ID: ENSG00000105552
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.01
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.01
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177556
Hovered Details

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Hovered Details

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**Key Characteristics** Plasmablasts are a subset of B cells that have been activated by antigens or infected cells. They exhibit several distinct characteristics, including: 1. **CD27 and CD38 expression**: Plasmablasts express CD27 and CD38, which are markers of activated B cells. 2. **CD138 negativity**: Plasmablasts lack the expression of CD138, a marker of plasma cells. 3. **Immunoglobulin secretion**: Plasmablasts are capable of secreting immunoglobulins, which are essential for the neutralization of pathogens. 4. **Proliferation and differentiation**: Plasmablasts undergo rapid proliferation and differentiation into antibody-secreting plasma cells. **Clinical Significance** Plasmablasts play a critical role in the adaptive immune response, particularly in the context of viral infections and autoimmune diseases. Their ability to rapidly proliferate and differentiate into antibody-secreting plasma cells enables them to: 1. **Neutralize pathogens**: Plasmablasts can produce antibodies that neutralize viruses and other pathogens. 2. **Induce immune tolerance**: Plasmablasts can induce immune tolerance by suppressing the activity of autoreactive T cells. 3. **Regulate the immune response**: Plasmablasts can regulate the immune response by modulating the activity of immune cells, such as dendritic cells and macrophages. **Pathways Involved** Plasmablasts are involved in several key pathways, including: 1. **Actin cytoskeleton regulation**: Plasmablasts require the regulation of the actin cytoskeleton to undergo rapid proliferation and differentiation. 2. **Apoptotic process**: Plasmablasts are involved in the regulation of the apoptotic process, which is essential for the removal of infected cells. 3. **Cell cycle regulation**: Plasmablasts require the regulation of the cell cycle to undergo rapid proliferation and differentiation. 4. **Transcriptional regulation**: Plasmablasts require the regulation of transcriptional processes to produce immunoglobulins and other critical proteins. **Gene Expression Profile** Plasmablasts exhibit a distinct gene expression profile, characterized by the expression of: 1. **ACTB**: Plasmablasts express ACTB, which is involved in the regulation of the actin cytoskeleton. 2. **SLC25A6**: Plasmablasts express SLC25A6, which is involved in the regulation of mitochondrial function. 3. **CALM1**: Plasmablasts express CALM1, which is involved in the regulation of the actin cytoskeleton. In conclusion, plasmablasts are a crucial component of the adaptive immune response, playing a key role in the neutralization of pathogens and the regulation of the immune response. Their ability to rapidly proliferate and differentiate into antibody-secreting plasma cells enables them to induce immune tolerance and regulate the immune response. Understanding the biology of plasmablasts is essential for the development of effective therapies for viral infections and autoimmune diseases.