Details for: CL0000982

Cell ID: CL0000982

Cell Name: IgG plasmablast

Marker Score Threshold: 276
(Derived using integrated single-cell and genomic data)

Description: A plasmablast that secretes IgG.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.78
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 3.27
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 3.12
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.74
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 2.68
    Ensembl ID: ENSG00000004468
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.55
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.54
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 2.54
    Ensembl ID: ENSG00000118971
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.51
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.44
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.4
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.35
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 2.27
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.21
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.15
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.15
    Ensembl ID: ENSG00000135404
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 2.09
    Ensembl ID: ENSG00000057657
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.07
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.05
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.01
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.98
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.92
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.91
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.84
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.77
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.75
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.74
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.73
    Ensembl ID: ENSG00000072778
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.69
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.69
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.67
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.65
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.61
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.6
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.56
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.56
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.55
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.54
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.51
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.51
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.46
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.4
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.38
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.37
    Ensembl ID: ENSG00000090861
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.32
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.32
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.31
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.31
    Ensembl ID: ENSG00000196776
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.26
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.25
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.24
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.24
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ENTPD1 (ENSG00000138185)
    Fold Change: 1.24
    Ensembl ID: ENSG00000138185
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.24
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.23
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BUB1 (ENSG00000169679)
    Fold Change: 1.23
    Ensembl ID: ENSG00000169679
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.2
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.17
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.16
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.15
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.15
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.12
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.11
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.1
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.1
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.1
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.09
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCNC (ENSG00000112237)
    Fold Change: 1.09
    Ensembl ID: ENSG00000112237
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.08
    Ensembl ID: ENSG00000126247
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.04
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CASP3 (ENSG00000164305)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164305
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142599
  • Gene Symbol: TNFRSF17 (ENSG00000048462)
    Fold Change: 1.04
    Ensembl ID: ENSG00000048462
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.03
    Ensembl ID: ENSG00000010278
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138760
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.03
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.02
    Ensembl ID: ENSG00000177697
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.02
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.02
    Ensembl ID: ENSG00000213465
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.01
    Ensembl ID: ENSG00000142192
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1
    Ensembl ID: ENSG00000196975
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Antibody production**: IgG plasmablasts are characterized by their ability to produce IgG antibodies, which are essential for neutralizing pathogens and other foreign substances. 2. **High proliferation rate**: IgG plasmablasts undergo rapid proliferation in response to antigen stimulation, allowing them to rapidly produce large quantities of antibodies. 3. **High expression of IgG heavy and light chains**: IgG plasmablasts express high levels of IgG heavy and light chains, which are secreted as functional antibodies. 4. **Activation of adaptive immune response**: IgG plasmablasts are involved in the activation of the adaptive immune response, which provides long-term immunity against pathogens. **Clinical Significance** 1. **Immunodeficiency diseases**: IgG plasmablasts play a crucial role in the humoral immune response, and their dysfunction can lead to immunodeficiency diseases, such as primary immunodeficiency disorders. 2. **Autoimmune diseases**: IgG plasmablasts can also contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by producing autoantibodies that target self-antigens. 3. **Cancer immunotherapy**: IgG plasmablasts can be targeted for cancer immunotherapy, as they can recognize and kill cancer cells that express specific antigens. 4. **Infectious diseases**: IgG plasmablasts play a crucial role in the humoral immune response against infectious diseases, such as influenza and HIV. **Pathways and Ontologies** IgG plasmablasts are involved in various cellular processes, including: 1. **Adaptive immune system**: IgG plasmablasts are involved in the activation of the adaptive immune response, which provides long-term immunity against pathogens. 2. **Antigen presentation**: IgG plasmablasts can present antigens to T cells, which is essential for the activation of the adaptive immune response. 3. **Amyloid fiber formation**: IgG plasmablasts can produce amyloid fibrils, which are associated with various diseases, including Alzheimer's disease and amyloidosis. 4. **Iron ion homeostasis**: IgG plasmablasts are involved in the regulation of iron ion homeostasis, which is essential for the proper functioning of the immune system. In conclusion, IgG plasmablasts are a crucial component of the adaptive immune response, and their dysfunction can lead to various diseases. Understanding the biology of IgG plasmablasts is essential for the development of novel immunotherapies and treatments for infectious diseases and autoimmune disorders.