Details for: CL0000984

Cell ID: CL0000984

Cell Name: IgA plasmablast

Marker Score Threshold: 263
(Derived using integrated single-cell and genomic data)

Description: A plasmablast that secretes IgA.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.45
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.84
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.84
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.72
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.44
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.36
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.29
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.25
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.24
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.21
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.17
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.15
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.15
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.1
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 2.06
    Ensembl ID: ENSG00000004468
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 2.01
    Ensembl ID: ENSG00000057657
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.99
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.98
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.96
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.91
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.91
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.9
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.86
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.81
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.8
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.77
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.72
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.64
    Ensembl ID: ENSG00000118971
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.62
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.61
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.59
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.55
    Ensembl ID: ENSG00000174437
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104765
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.52
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.51
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.51
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.48
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.47
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.43
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.39
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116489
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.35
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.35
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.34
    Ensembl ID: ENSG00000128595
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.32
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.32
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.31
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.29
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.28
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.28
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.23
    Ensembl ID: ENSG00000110651
  • Gene Symbol: TNFRSF17 (ENSG00000048462)
    Fold Change: 1.22
    Ensembl ID: ENSG00000048462
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.22
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.22
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.21
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.21
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.19
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.18
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.17
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149925
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.16
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.16
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ENTPD1 (ENSG00000138185)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138185
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.1
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.09
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.08
    Ensembl ID: ENSG00000183255
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.07
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.06
    Ensembl ID: ENSG00000213465
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165272
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.04
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177697
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.02
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1
    Ensembl ID: ENSG00000060971
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1
    Ensembl ID: ENSG00000026508
Hovered Details

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Hovered Details

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**Key Characteristics** IgA plasmablasts are characterized by their: 1. **Expression of IgA heavy chain**: IgA plasmablasts express the IgA heavy chain gene (B2M), which is responsible for the production of IgA antibodies. 2. **High expression of IgA**: IgA plasmablasts produce large amounts of IgA antibodies, which are secreted into the mucosal environment. 3. **Activation of B cells**: IgA plasmablasts can differentiate from activated B cells, which are stimulated by antigens or cytokines. 4. **Antigen presentation**: IgA plasmablasts can present antigens to T cells, which helps to activate the adaptive immune response. 5. **Production of cytokines**: IgA plasmablasts produce cytokines, such as IL-10 and IL-12, which help to regulate the immune response. **Clinical Significance** IgA plasmablasts play a crucial role in the adaptive immune response, particularly in the context of mucosal infections. They are involved in the prevention of: 1. **Mucosal infections**: IgA plasmablasts help to neutralize pathogens at the mucosal surface, preventing their entry into the body. 2. **Allergic diseases**: IgA plasmablasts are involved in the regulation of allergic responses, such as atopic dermatitis and asthma. 3. **Autoimmune diseases**: IgA plasmablasts can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cancer**: IgA plasmablasts can produce antibodies that help to target cancer cells, making them a potential therapeutic target. **Regulation of IgA Plasmablasts** IgA plasmablasts are regulated by a variety of mechanisms, including: 1. **Cytokine signaling**: Cytokines, such as IL-10 and IL-12, help to regulate the activity of IgA plasmablasts. 2. **Antigen presentation**: Antigen presentation by IgA plasmablasts helps to activate the adaptive immune response. 3. **Cell-cell interactions**: Cell-cell interactions between IgA plasmablasts and other immune cells, such as T cells and dendritic cells, help to regulate their activity. In conclusion, IgA plasmablasts are a key player in the adaptive immune response, particularly in the context of mucosal infections. Their ability to produce IgA antibodies and present antigens to T cells makes them a crucial component of the immune system.