Details for: CL0000990

Cell ID: CL0000990

Cell Name: conventional dendritic cell

Marker Score Threshold: 690
(Derived using integrated single-cell and genomic data)

Description: Conventional dendritic cell is a dendritic cell that is CD11c-high.

Synonyms: interdigitating cell, veiled cell, DC1, cDC, dendritic reticular cell, type 1 DC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.07
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.6
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.59
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.58
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.53
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198668
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 2.21
    Ensembl ID: ENSG00000224389
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.21
    Ensembl ID: ENSG00000143933
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 2.2
    Ensembl ID: ENSG00000244731
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 2.2
    Ensembl ID: ENSG00000163286
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 2.2
    Ensembl ID: ENSG00000165462
  • Gene Symbol: ART4 (ENSG00000111339)
    Fold Change: 2.2
    Ensembl ID: ENSG00000111339
  • Gene Symbol: AVPR2 (ENSG00000126895)
    Fold Change: 2.2
    Ensembl ID: ENSG00000126895
  • Gene Symbol: OPN1SW (ENSG00000128617)
    Fold Change: 2.2
    Ensembl ID: ENSG00000128617
  • Gene Symbol: BNC1 (ENSG00000169594)
    Fold Change: 2.19
    Ensembl ID: ENSG00000169594
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.19
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 2.19
    Ensembl ID: ENSG00000170214
  • Gene Symbol: BMP3 (ENSG00000152785)
    Fold Change: 2.18
    Ensembl ID: ENSG00000152785
  • Gene Symbol: BTC (ENSG00000174808)
    Fold Change: 2.17
    Ensembl ID: ENSG00000174808
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.05
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.05
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.03
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.97
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.96
    Ensembl ID: ENSG00000134825
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.94
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.9
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.9
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.86
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.85
    Ensembl ID: ENSG00000135046
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.84
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.81
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.8
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.79
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.77
    Ensembl ID: ENSG00000180772
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.77
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.76
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.75
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.71
    Ensembl ID: ENSG00000152518
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: 1.67
    Ensembl ID: ENSG00000156006
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.63
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.62
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.58
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.58
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.56
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.53
    Ensembl ID: ENSG00000070961
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.53
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.52
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.5
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 1.49
    Ensembl ID: ENSG00000144891
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.48
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.47
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.46
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.45
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.43
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.41
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.4
    Ensembl ID: ENSG00000015475
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.4
    Ensembl ID: ENSG00000160014
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.39
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.37
    Ensembl ID: ENSG00000168374
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.36
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.33
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.33
    Ensembl ID: ENSG00000111275
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.32
    Ensembl ID: ENSG00000115307
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.3
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.26
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.19
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.19
    Ensembl ID: ENSG00000141480
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.18
    Ensembl ID: ENSG00000060971
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.18
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.17
    Ensembl ID: ENSG00000090013
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.15
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.11
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.11
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.1
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.1
    Ensembl ID: ENSG00000071553
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.05
    Ensembl ID: ENSG00000140299
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.01
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134287
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1
    Ensembl ID: ENSG00000156273
Hovered Details

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Hovered Details

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**Key Characteristics** Conventional dendritic cells are characterized by their: 1. **High expression of CD11c**: cDCs express high levels of CD11c, a marker that distinguishes them from other dendritic cell subsets. 2. **Antigen-presenting capabilities**: cDCs have the ability to capture and process antigens, then present them to T cells via MHC class I and II molecules. 3. **Cytokine production**: cDCs produce a range of cytokines, including IL-12, IL-6, and TNF-α, which regulate immune responses. 4. **Regulation of immune responses**: cDCs can modulate immune responses by producing cytokines and interacting with T cells. 5. **Involvement in iron homeostasis**: cDCs are involved in the regulation of iron homeostasis and have been implicated in the pathogenesis of iron deficiency anemia. 6. **Involvement in HIV-1 infection**: cDCs have been implicated in the pathogenesis of HIV-1 infection, where they can capture and process viral antigens, leading to the activation of an immune response. 7. **Involvement in Mycobacterium tuberculosis infection**: cDCs have been implicated in the pathogenesis of Mycobacterium tuberculosis infection, where they can present antigens to T cells, leading to the activation of an immune response. **Clinical Significance** Conventional dendritic cells have significant clinical implications in various diseases, including: 1. **HIV-1 infection**: cDCs play a crucial role in the pathogenesis of HIV-1 infection, where they can capture and process viral antigens, leading to the activation of an immune response. 2. **Mycobacterium tuberculosis infection**: cDCs have been implicated in the pathogenesis of Mycobacterium tuberculosis infection, where they can present antigens to T cells, leading to the activation of an immune response. 3. **Autoimmune diseases**: cDCs have been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where they can present antigens to T cells, leading to the activation of an immune response. 4. **Cancer**: cDCs have been implicated in the pathogenesis of cancer, where they can present antigens to T cells, leading to the activation of an immune response. 5. **Vaccine development**: cDCs are being explored as a target for vaccine development, where they can be used to present antigens to T cells, leading to the activation of an immune response. In summary, conventional dendritic cells are a crucial component of the adaptive immune response, playing a significant role in the regulation of immune responses, antigen presentation, and cytokine production. Their involvement in various diseases, including HIV-1 infection, Mycobacterium tuberculosis infection, autoimmune diseases, cancer, and vaccine development, highlights their importance in understanding immune function and developing novel therapeutic strategies.