Details for: CL0001050

Cell ID: CL0001050

Cell Name: effector CD8-positive, alpha-beta T cell

Marker Score Threshold: 842
(Derived using integrated single-cell and genomic data)

Description: A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.

Synonyms: effector CD8+ T cell, effector CD8-positive, alpha-beta T lymphocyte, effector CD8-positive, alpha-beta T-cell, effector CD8-positive, alpha-beta T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.8
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.74
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.7
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.7
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.66
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.66
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.65
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.56
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.52
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.46
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.3
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.27
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.18
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.13
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 2.97
    Ensembl ID: ENSG00000160654
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.77
    Ensembl ID: ENSG00000173762
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.75
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.7
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.69
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.6
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.45
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 2.45
    Ensembl ID: ENSG00000198821
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 2.45
    Ensembl ID: ENSG00000020633
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.38
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.37
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 2.37
    Ensembl ID: ENSG00000153563
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.36
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.34
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.28
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.27
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.2
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.18
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.14
    Ensembl ID: ENSG00000149925
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 2.12
    Ensembl ID: ENSG00000184922
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.1
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.03
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.99
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.96
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 1.96
    Ensembl ID: ENSG00000172116
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.89
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.87
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.84
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.84
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.82
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.82
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.78
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.75
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.74
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.73
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.7
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.65
    Ensembl ID: ENSG00000196954
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.64
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.63
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.63
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.62
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.6
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.59
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.59
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.59
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.57
    Ensembl ID: ENSG00000004059
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.57
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.56
    Ensembl ID: ENSG00000085224
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.55
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.5
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.5
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.49
    Ensembl ID: ENSG00000117410
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.37
    Ensembl ID: ENSG00000173020
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.36
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.34
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.34
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.32
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.32
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.31
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.29
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149311
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.27
    Ensembl ID: ENSG00000147872
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.26
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.24
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 1.22
    Ensembl ID: ENSG00000013725
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.2
    Ensembl ID: ENSG00000114423
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.18
    Ensembl ID: ENSG00000057657
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.17
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.13
    Ensembl ID: ENSG00000070961
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143799
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.07
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.07
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.05
    Ensembl ID: ENSG00000118971
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
Hovered Details

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Hovered Details

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**Key Characteristics** Effector CD8-positive, alpha-beta T cells are characterized by the following key features: 1. **Cytotoxic T cell function**: Effector CD8-positive, alpha-beta T cells are capable of killing infected cells or tumor cells through the release of cytotoxins, such as granzymes and perforins. 2. **Antigen presentation**: These cells express MHC class I molecules, which present peptides from inside the cell to CD8+ T cells, facilitating recognition and killing of infected cells. 3. **CCR7-negative**: Effector CD8-positive, alpha-beta T cells are CCR7-negative, indicating that they do not express the chemokine receptor CCR7, which is typically involved in the homing of T cells to lymphoid tissues. 4. **CD45RA-positive**: These cells express CD45RA, a marker that is typically associated with naive T cells, indicating that they have undergone clonal expansion and differentiation into effector cells. 5. **Gene expression**: Effector CD8-positive, alpha-beta T cells express a specific set of genes, including those involved in cytokine signaling, immune regulation, and cell survival. **Clinical Significance** Effector CD8-positive, alpha-beta T cells play a critical role in the adaptive immune response, and their dysfunction or dysregulation can contribute to various diseases, including: 1. **Autoimmune diseases**: Effector CD8-positive, alpha-beta T cells can contribute to autoimmune diseases, such as multiple sclerosis, by recognizing and killing self-antigen-presenting cells. 2. **Cancer**: These cells can recognize and kill cancer cells, but their ability to do so can be impaired in certain types of cancer, such as melanoma. 3. **Viral infections**: Effector CD8-positive, alpha-beta T cells are essential for controlling viral infections, such as HIV, by recognizing and killing infected cells. 4. **Inflammatory diseases**: These cells can contribute to inflammatory diseases, such as rheumatoid arthritis, by promoting inflammation and tissue damage. In summary, effector CD8-positive, alpha-beta T cells are a crucial component of the adaptive immune response, and their dysfunction or dysregulation can contribute to various diseases. Understanding the biology and function of these cells is essential for developing effective therapeutic strategies to prevent and treat immune-related disorders.