Details for: CL0001057

Cell ID: CL0001057

Cell Name: myeloid dendritic cell, human

Marker Score Threshold: 358
(Derived using integrated single-cell and genomic data)

Description: A myeloid dendritic cell with the phenotype HLA-DRA-positive.

Synonyms: myeloid dendritic cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.91
    Ensembl ID: ENSG00000166710
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.49
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.49
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.46
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.42
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.37
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.37
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.3
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.25
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.16
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.1
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.07
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.06
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.96
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.95
    Ensembl ID: ENSG00000112695
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.94
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.92
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.9
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143933
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.84
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.82
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.8
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.74
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.74
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.72
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.71
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.7
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.67
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.66
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.65
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.63
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.58
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.57
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.56
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.55
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.54
    Ensembl ID: ENSG00000172270
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.53
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.52
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.5
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.49
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.48
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.46
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.46
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.42
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.41
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.4
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.37
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.34
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.32
    Ensembl ID: ENSG00000161203
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.3
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.29
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.28
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.27
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.27
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.23
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.23
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.22
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.22
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.19
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.18
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.13
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110651
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.12
    Ensembl ID: ENSG00000053254
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.11
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.11
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.09
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.08
    Ensembl ID: ENSG00000153922
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.05
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.04
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.04
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.02
    Ensembl ID: ENSG00000115307
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.01
    Ensembl ID: ENSG00000122218
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.01
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.01
    Ensembl ID: ENSG00000074201
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1
    Ensembl ID: ENSG00000100823
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: N/A
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: N/A
    Ensembl ID: ENSG00000112576
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** Myeloid dendritic cells are characterized by their: 1. **HLA-DRA positivity**: DCs express the HLA-DRA molecule, which is a component of the major histocompatibility complex (MHC) class II. 2. **Actin cytoskeleton**: DCs have a dynamic actin cytoskeleton that is involved in their movement, phagocytosis, and antigen presentation. 3. **Adherens junctions**: DCs form adherens junctions with other cells, which are essential for their function in antigen presentation and immune response. 4. **Apoptosis**: DCs can undergo apoptosis, which is a process of programmed cell death that is involved in the regulation of the immune response. 5. **Cytokine production**: DCs produce a variety of cytokines, including IL-12, IL-6, and TNF-alpha, which are involved in the regulation of the immune response. **Clinical Significance** Myeloid dendritic cells play a crucial role in various diseases and conditions, including: 1. **Cancer**: DCs are involved in the recognition and elimination of tumor cells, and their dysfunction can contribute to cancer progression. 2. **Infectious diseases**: DCs are involved in the recognition and elimination of pathogens, and their dysfunction can contribute to the development of infections. 3. **Autoimmune diseases**: DCs are involved in the regulation of the immune response, and their dysfunction can contribute to the development of autoimmune diseases. 4. **Immunodeficiency**: DCs are involved in the recognition and elimination of pathogens, and their dysfunction can contribute to immunodeficiency. **Functions** Myeloid dendritic cells have several functions, including: 1. **Antigen presentation**: DCs process and present antigens to T-cells, which is essential for the initiation of an immune response. 2. **Immune response regulation**: DCs produce cytokines and other molecules that regulate the immune response, including the activation of T-cells and the suppression of immune responses. 3. **Phagocytosis**: DCs can phagocytose pathogens and other foreign substances, which is essential for the elimination of pathogens and the regulation of the immune response. 4. **Cytokine production**: DCs produce cytokines that are involved in the regulation of the immune response, including the activation of T-cells and the suppression of immune responses. In conclusion, myeloid dendritic cells are a crucial component of the adaptive immune system, and their dysfunction can contribute to various diseases and conditions. A better understanding of the functions and characteristics of DCs is essential for the development of new therapeutic strategies for the treatment of immune-related diseases.