Details for: CL0001058

Cell ID: CL0001058

Cell Name: plasmacytoid dendritic cell, human

Marker Score Threshold: 263
(Derived using integrated single-cell and genomic data)

Description: A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative.

Synonyms: plasmacytoid dendritic cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.55
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.3
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.97
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.82
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.55
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.53
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.39
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.31
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.27
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.13
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.1
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.94
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.93
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.85
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.83
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.79
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.78
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.77
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.74
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.73
    Ensembl ID: ENSG00000128272
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.72
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.72
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.67
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.66
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.63
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.62
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.59
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.59
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.58
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.56
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.56
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.55
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.48
    Ensembl ID: ENSG00000142192
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.47
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.46
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.46
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.44
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.44
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.43
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.43
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.41
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.4
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.38
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.34
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.32
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.3
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.28
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.27
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.27
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.26
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.25
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.23
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.23
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.23
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.2
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.18
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.16
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.14
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143119
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.13
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.13
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.11
    Ensembl ID: ENSG00000112576
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.11
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.1
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.08
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.08
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.07
    Ensembl ID: ENSG00000145349
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.07
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.06
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.03
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.01
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.01
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1
    Ensembl ID: ENSG00000168675
Hovered Details

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Hovered Details

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**Key Characteristics** * **Phenotype**: HLA-DRA-positive, CD123-positive, and CD11c-negative * **Function**: Recognize and process viral nucleic acids, leading to the production of type I interferons * **Antigen presentation**: pDCs can present antigens to T cells through MHC class I and II molecules * **Cytokine production**: pDCs produce cytokines such as IFN-α, IFN-β, and IL-6 in response to viral infections * **Cell-cell interactions**: pDCs interact with other immune cells, including T cells, macrophages, and B cells, to regulate immune responses * **Viral recognition**: pDCs recognize viral nucleic acids through pattern recognition receptors such as RIG-I and MDA5 **Clinical Significance** * **Viral infections**: pDCs play a crucial role in the defense against viral infections, particularly those caused by RNA viruses such as influenza and herpes simplex virus * **Autoimmune diseases**: pDCs have been implicated in the pathogenesis of autoimmune diseases such as lupus and multiple sclerosis * **Cancer**: pDCs have been shown to play a role in the regulation of tumor immunity and the production of cytokines that promote tumor growth * **Transplantation**: pDCs have been implicated in the rejection of transplanted organs and the development of chronic allograft nephropathy * **Immunotherapy**: pDCs have been explored as a target for immunotherapy in cancer and autoimmune diseases In conclusion, the plasmacytoid dendritic cell is a key player in the innate immune system, involved in the recognition and processing of viral nucleic acids, and plays a crucial role in the regulation of immune responses. Its dysregulation has been implicated in various diseases, including viral infections, autoimmune diseases, cancer, and transplantation. Further research is needed to fully understand the role of pDCs in human health and disease.