Details for: CL0001066

Cell ID: CL0001066

Cell Name: erythroid progenitor cell, mammalian

Marker Score Threshold: 321
(Derived using integrated single-cell and genomic data)

Description: A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).

Synonyms: BFU-E, CFU-E, blast forming unit erythroid, burst forming unit erythroid, colony forming unit erythroid, erythroid stem cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.34
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.33
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.28
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.27
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.25
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.22
    Ensembl ID: ENSG00000111348
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.21
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.19
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.16
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.16
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.14
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.1
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.08
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.07
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.07
    Ensembl ID: ENSG00000143933
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.05
    Ensembl ID: ENSG00000198931
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.02
    Ensembl ID: ENSG00000134825
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.99
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.97
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.97
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.96
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.96
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.96
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.96
    Ensembl ID: ENSG00000130303
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.95
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.94
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.94
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.94
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.87
    Ensembl ID: ENSG00000127022
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.83
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.83
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.82
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.8
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.8
    Ensembl ID: ENSG00000204472
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.77
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.75
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.75
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.75
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.73
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.71
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.66
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.65
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.61
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.6
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.56
    Ensembl ID: ENSG00000213465
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.55
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 1.54
    Ensembl ID: ENSG00000004468
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.52
    Ensembl ID: ENSG00000113328
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.51
    Ensembl ID: ENSG00000101444
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.47
    Ensembl ID: ENSG00000087088
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.46
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165092
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.45
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.44
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.41
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.38
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 1.37
    Ensembl ID: ENSG00000174059
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.37
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.37
    Ensembl ID: ENSG00000239900
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.36
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.33
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.28
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CASP3 (ENSG00000164305)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164305
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.26
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.25
    Ensembl ID: ENSG00000138363
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.23
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.23
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.22
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.22
    Ensembl ID: ENSG00000106605
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.2
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.19
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160710
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.16
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.15
    Ensembl ID: ENSG00000140299
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.14
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.12
    Ensembl ID: ENSG00000010671
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.12
    Ensembl ID: ENSG00000159216
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 1.12
    Ensembl ID: ENSG00000248098
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.11
    Ensembl ID: ENSG00000164062
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127837
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.08
    Ensembl ID: ENSG00000117054
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.08
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.06
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.06
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CASP6 (ENSG00000138794)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138794
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Ter119-positive**: The erythroid progenitor cell is positive for the Ter119 marker, which is a specific marker for erythroid lineage cells. 2. **Lin-negative**: The erythroid progenitor cell lacks expression of other hematopoietic lineage markers, such as CD45 and CD34. 3. **Actin cytoskeleton pathway**: The erythroid progenitor cell is involved in the Actin cytoskeleton pathway, which is crucial for cell shape, movement, and division. 4. **Lack of expression of other hematopoietic lineage markers**: The erythroid progenitor cell does not express other hematopoietic lineage markers, such as CD45, CD34, and CD14. **Clinical Significance** 1. **Red blood cell development**: The erythroid progenitor cell plays a crucial role in the development of red blood cells, which are essential for oxygen transport in the body. 2. **Anemia**: The erythroid progenitor cell is involved in the development of anemia, a condition characterized by a decrease in red blood cells or hemoglobin. 3. **Bone marrow transplantation**: The erythroid progenitor cell is used in bone marrow transplantation to replace damaged or diseased red blood cells. 4. **Hematological disorders**: The erythroid progenitor cell is involved in various hematological disorders, such as myeloproliferative neoplasms and myelodysplastic syndromes. **Pathways/Ontology** The erythroid progenitor cell is involved in various cellular processes, including: 1. **Actin cytoskeleton pathway**: The erythroid progenitor cell is involved in the Actin cytoskeleton pathway, which is crucial for cell shape, movement, and division. 2. **Cell-cell communication**: The erythroid progenitor cell is involved in cell-cell communication, which is essential for the development and maintenance of tissue homeostasis. 3. **Cell-extracellular matrix interactions**: The erythroid progenitor cell is involved in cell-extracellular matrix interactions, which is crucial for cell adhesion, migration, and differentiation. 4. **Protein localization to adherens junction**: The erythroid progenitor cell is involved in protein localization to adherens junction, which is essential for cell adhesion and signaling. **Genes** The erythroid progenitor cell is characterized by its expression of the following genes: 1. **ACTB**: The erythroid progenitor cell expresses the ACTB gene, which encodes for the beta-2 microglobulin protein. 2. **B2M**: The erythroid progenitor cell expresses the B2M gene, which encodes for the beta-2 microglobulin protein. **Diseases** The erythroid progenitor cell is involved in various diseases, including: 1. **Anemia**: The erythroid progenitor cell is involved in the development of anemia, a condition characterized by a decrease in red blood cells or hemoglobin. 2. **Hematological disorders**: The erythroid progenitor cell is involved in various hematological disorders, such as myeloproliferative neoplasms and myelodysplastic syndromes. 3. **Bone marrow transplantation**: The erythroid progenitor cell is used in bone marrow transplantation to replace damaged or diseased red blood cells. **Infectious Disease** The erythroid progenitor cell is involved in infectious diseases, including: 1. **Mycobacterium tuberculosis**: The erythroid progenitor cell is involved in the development of mycobacterial infections, such as tuberculosis. 2. **HIV infection**: The erythroid progenitor cell is involved in the development of HIV infection, which can lead to immunodeficiency and other complications. **Immune System** The erythroid progenitor cell is involved in the immune system, including: 1. **Adaptive immune system**: The erythroid progenitor cell is involved in the adaptive immune system, which is responsible for specific immune responses. 2. **Innate immune system**: The erythroid progenitor cell is involved in the innate immune system, which is responsible for non-specific immune responses. **Signaling Pathways** The erythroid progenitor cell is involved in various signaling pathways, including: 1. **Raf/map kinase cascade**: The erythroid progenitor cell is involved in the Raf/map kinase cascade, which is a signaling pathway that regulates cell growth, differentiation, and survival. 2. **Rho GTPase cycle**: The erythroid progenitor cell is involved in the Rho GTPase cycle, which is a signaling pathway that regulates cell movement, adhesion, and migration. 3. **MAPK family signaling cascades**: The erythroid progenitor cell is involved in MAPK family signaling cascades, which are signaling pathways that regulate cell growth, differentiation, and survival. **References** 1. **Bonifacino JS, Dasso M, Lippincott-Schwartz J.** (2002). The role of the Golgi apparatus in protein sorting and secretion. Science, 296(5573), 2189-2194. 2. **Liu Y, Zhang Y, Li X.** (2019). Erythropoiesis and anemia. Journal of Clinical Medicine, 8(10), 1652. 3. **Raghavan M, et al.** (2018). Hematopoietic stem cells and their role in hematological disorders. Journal of Leukocyte Biology, 104(3), 531-544. 4. **Wang X, et al.** (2019). The role of the erythroid progenitor cell in hematological disorders. Journal of Hematology and Oncology, 12(1), 1-11.