Details for: CL0001069

Cell ID: CL0001069

Cell Name: group 2 innate lymphoid cell

Marker Score Threshold: 340
(Derived using integrated single-cell and genomic data)

Description: An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation.

Synonyms: ILC2, natural helper cell, nuocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.97
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.39
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.37
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.36
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.33
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.3
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.26
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.18
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.12
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.02
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.98
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.97
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.94
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.92
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.89
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.86
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.86
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135404
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.82
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.77
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.69
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.69
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.65
    Ensembl ID: ENSG00000176340
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.65
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.58
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.51
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.5
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.5
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.5
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.49
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.49
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.48
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.47
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.47
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.45
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.45
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.45
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.45
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.43
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.43
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.39
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.38
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.37
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.34
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.33
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.33
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.32
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.31
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.27
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.27
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.25
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.22
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.22
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.21
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.21
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.2
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.2
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.18
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.17
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.17
    Ensembl ID: ENSG00000026508
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.16
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.13
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.12
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.12
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.12
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.1
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.09
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.09
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.08
    Ensembl ID: ENSG00000085063
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141367
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.07
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.07
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CSNK2B (ENSG00000204435)
    Fold Change: 1.05
    Ensembl ID: ENSG00000204435
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.05
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138279
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.04
    Ensembl ID: ENSG00000108561
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.03
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.03
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1
    Ensembl ID: ENSG00000112576
Hovered Details

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Hovered Details

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**Key Characteristics** ILC2s are characterized by their expression of specific surface markers, including CD127, CD103, and CD161. They are also known to produce T-helper 2-cell associated cytokines, such as IL-5, IL-9, and IL-13, in response to stimulation. These cytokines play a crucial role in recruiting eosinophils and mast cells to sites of infection or inflammation. ILC2s are also known to interact with other immune cells, including T cells, dendritic cells, and macrophages, to facilitate the initiation of immune responses. **Clinical Significance** ILC2s have been implicated in various diseases, including: 1. **Asthma**: ILC2s are thought to play a key role in the development of asthma by recruiting eosinophils and mast cells to the airways. 2. **Atopic dermatitis**: ILC2s have been implicated in the pathogenesis of atopic dermatitis by producing cytokines that recruit eosinophils and mast cells to the skin. 3. **Parasitic infections**: ILC2s have been shown to play a crucial role in the immune response to parasitic infections, such as hookworm and schistosomiasis. **Pathways Involved** ILC2s interact with various pathways to facilitate the initiation of immune responses, including: 1. **Cytokine signaling**: ILC2s produce T-helper 2-cell associated cytokines, such as IL-5, IL-9, and IL-13, which play a crucial role in recruiting eosinophils and mast cells to sites of infection or inflammation. 2. **Cell-cell interactions**: ILC2s interact with other immune cells, including T cells, dendritic cells, and macrophages, to facilitate the initiation of immune responses. 3. **Adhesion molecule signaling**: ILC2s express adhesion molecules, such as L-selectin and CD62L, which facilitate the recruitment of eosinophils and mast cells to sites of infection or inflammation. **Conclusion** Group 2 innate lymphoid cells are a crucial component of the innate immune system, playing a key role in the recruitment of eosinophils and mast cells to sites of infection or inflammation. Their ability to produce T-helper 2-cell associated cytokines and interact with other immune cells makes them an important target for the development of novel therapeutic strategies for various diseases, including asthma, atopic dermatitis, and parasitic infections.