Details for: CL0001071

Cell ID: CL0001071

Cell Name: group 3 innate lymphoid cell

Marker Score Threshold: 420
(Derived using integrated single-cell and genomic data)

Description: An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22.

Synonyms: ILC3

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.18
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.05
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.82
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.71
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.7
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.69
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.6
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.36
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.31
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.31
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.29
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.12
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.06
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.04
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.04
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.01
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.85
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.81
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.79
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.77
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.76
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.75
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.75
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.73
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.67
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.67
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.64
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.59
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.59
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.58
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.58
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.57
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.56
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.56
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.49
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.47
    Ensembl ID: ENSG00000241837
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.42
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.41
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.38
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.36
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.36
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.34
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.33
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.33
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.26
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.26
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.26
    Ensembl ID: ENSG00000182718
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.24
    Ensembl ID: ENSG00000115307
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.24
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.23
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.21
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.21
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.21
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.19
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.14
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.13
    Ensembl ID: ENSG00000162772
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.11
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.09
    Ensembl ID: ENSG00000121691
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.07
    Ensembl ID: ENSG00000109321
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.06
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.06
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.05
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.04
    Ensembl ID: ENSG00000123146
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.02
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110848
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.01
    Ensembl ID: ENSG00000107262
Hovered Details

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Hovered Details

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**Key Characteristics** ILC3 are characterized by the following key features: 1. **RORγt expression**: ILC3 constitutively express RORγt, which is a transcription factor that regulates the expression of genes involved in immune responses. 2. **IL-17A and/or IL-22 production**: ILC3 are capable of producing the cytokines IL-17A and/or IL-22, which are involved in inflammation and antimicrobial defense. 3. **Adhesion and migration**: ILC3 are capable of adhering to and migrating through the endothelium, which allows them to reach sites of inflammation and infection. 4. **Apoptosis**: ILC3 are capable of undergoing apoptosis, which allows them to regulate the immune response and prevent excessive inflammation. 5. **Tissue localization**: ILC3 are found in various tissues, including the lungs, skin, and gut, where they play a role in immune responses to pathogens and allergens. **Clinical Significance** ILC3 have been implicated in several diseases, including: 1. **Autoimmune disorders**: ILC3 have been implicated in autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Inflammatory bowel disease**: ILC3 have been implicated in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. 3. **Cancer**: ILC3 have been implicated in cancer, including lung cancer and colon cancer. 4. **Infection**: ILC3 are involved in immune responses to infections, including tuberculosis and malaria. 5. **Allergic diseases**: ILC3 have been implicated in allergic diseases, including asthma and atopic dermatitis. In summary, ILC3 are a subset of innate immune cells that play a crucial role in the early stages of immune responses. Their dysregulation has been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. Further research is needed to fully understand the role of ILC3 in human health and disease.