Details for: CL0001076

Cell ID: CL0001076

Cell Name: NKp46-positive innate lymphoid cell, human

Marker Score Threshold: 2919
(Derived using integrated single-cell and genomic data)

Description: An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells.

Synonyms: NKp46-positive ILC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 5.55
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 5.19
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 5.04
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.98
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 4.76
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 4.73
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 4.72
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.54
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 4.49
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.22
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 3.97
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.75
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 3.65
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.64
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.58
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.56
    Ensembl ID: ENSG00000110848
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.55
    Ensembl ID: ENSG00000135046
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.4
    Ensembl ID: ENSG00000122545
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.37
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 3.28
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.27
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.26
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 3.17
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.04
    Ensembl ID: ENSG00000143933
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 3.02
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.96
    Ensembl ID: ENSG00000077549
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 2.94
    Ensembl ID: ENSG00000109321
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.93
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.89
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.87
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.82
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.72
    Ensembl ID: ENSG00000165527
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.57
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.52
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.52
    Ensembl ID: ENSG00000197043
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.48
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.45
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.44
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 2.39
    Ensembl ID: ENSG00000123146
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.37
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.32
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 2.31
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.31
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.26
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.07
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 2.03
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.01
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.99
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.96
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.95
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.94
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.91
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.89
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.84
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.83
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.83
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.79
    Ensembl ID: ENSG00000185650
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.74
    Ensembl ID: ENSG00000184922
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.69
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.62
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.61
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.61
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.6
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 1.57
    Ensembl ID: ENSG00000136250
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.56
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.5
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.46
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.45
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.44
    Ensembl ID: ENSG00000141480
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.42
    Ensembl ID: ENSG00000057657
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.4
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.39
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.39
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.38
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.38
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.34
    Ensembl ID: ENSG00000064012
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: 1.34
    Ensembl ID: ENSG00000151651
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.33
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.32
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.28
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.28
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.27
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.25
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.24
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.22
    Ensembl ID: ENSG00000169252
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.22
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.19
    Ensembl ID: ENSG00000118971
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.19
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.11
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.06
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104763
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.03
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1
    Ensembl ID: ENSG00000160710
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **NKp46-positive**: The cell expresses the NKp46 receptor, which is a key marker for NKp46-positive innate lymphoid cells. 2. **Precursor for NK cells and ILC3 cells**: NKp46-positive innate lymphoid cells are a precursor for both NK cells and ILC3 cells, which are important components of the innate and adaptive immune systems. 3. **Innate immune system**: NKp46-positive innate lymphoid cells play a crucial role in the innate immune system, particularly in the recognition and elimination of pathogens and tumor cells. 4. **Recognition of ligands**: The NKp46 receptor on these cells recognizes ligands on the surface of pathogens and tumor cells, leading to the activation of immune responses. 5. **Interaction with other immune cells**: NKp46-positive innate lymphoid cells interact with other immune cells, such as dendritic cells and T cells, to coordinate an effective immune response. **Clinical Significance** 1. **Immunodeficiency disorders**: Defects in the NKp46 receptor or its signaling pathway have been associated with immunodeficiency disorders, such as NK cell deficiency and ILC3 deficiency. 2. **Cancer immunotherapy**: NKp46-positive innate lymphoid cells have been investigated as a potential target for cancer immunotherapy, as they can recognize and eliminate tumor cells. 3. **Viral infections**: NKp46-positive innate lymphoid cells play a crucial role in the recognition and elimination of viral infections, such as HIV and SARS-CoV-2. 4. **Autoimmune diseases**: NKp46-positive innate lymphoid cells have been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 5. **Innate immune system dysregulation**: Dysregulation of the innate immune system, including the function of NKp46-positive innate lymphoid cells, has been associated with various diseases, including cancer and autoimmune diseases. In conclusion, NKp46-positive innate lymphoid cells are an important component of the innate immune system, playing a crucial role in the recognition and elimination of pathogens and tumor cells. Understanding the function and dysregulation of these cells is essential for the development of effective immunotherapies and treatments for various diseases.