Details for: CL0001078

Cell ID: CL0001078

Cell Name: group 3 innate lymphoid cell, human

Marker Score Threshold: 358
(Derived using integrated single-cell and genomic data)

Description: A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive.

Synonyms: ILC3, human

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.95
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.67
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.45
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.4
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.36
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.34
    Ensembl ID: ENSG00000131143
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.32
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.24
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.05
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.98
    Ensembl ID: ENSG00000126267
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.94
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.94
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.87
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.87
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.84
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.83
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.78
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.76
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.76
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.74
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.71
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.69
    Ensembl ID: ENSG00000169020
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.68
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.61
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.61
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.58
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.57
    Ensembl ID: ENSG00000154518
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.57
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.56
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.56
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.54
    Ensembl ID: ENSG00000153113
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.51
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.5
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.5
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.49
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.49
    Ensembl ID: ENSG00000122705
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.47
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.45
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.44
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.43
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.43
    Ensembl ID: ENSG00000019582
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.37
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.36
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.35
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.34
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.33
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.31
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.28
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.26
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196776
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.25
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.24
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.22
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.21
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.2
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104765
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.19
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.13
    Ensembl ID: ENSG00000177879
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.12
    Ensembl ID: ENSG00000108561
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.11
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.1
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.07
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.07
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.07
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.06
    Ensembl ID: ENSG00000070961
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.06
    Ensembl ID: ENSG00000053254
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.04
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.04
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.03
    Ensembl ID: ENSG00000175416
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.03
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.02
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: N/A
    Ensembl ID: ENSG00000087274
Hovered Details

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Hovered Details

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**Key Characteristics** ILC3s are characterized by their unique expression of specific surface markers, including IL-7Rα, and their ability to produce a range of cytokines, including IL-22, IL-26, and IL-17A. These cytokines play a crucial role in the regulation of immune responses, including the recruitment of immune cells to sites of infection and the modulation of inflammation. ILC3s also express a range of adhesion molecules, including L1CAM and CD103, which facilitate their migration to sites of infection and their interaction with other immune cells. In addition to their cytokine production and adhesion molecule expression, ILC3s also exhibit a range of morphological characteristics, including the formation of lamellipodia and the expression of actin filaments. These structures are essential for the movement and interaction of ILC3s with other cells and their environment. **Clinical Significance** ILC3s play a crucial role in the regulation of immune responses, and their dysfunction has been implicated in a range of immune-mediated disorders, including inflammatory bowel disease, asthma, and autoimmune diseases. The identification of ILC3s and their role in immune homeostasis has also provided new insights into the development of novel therapeutic strategies for the treatment of these disorders. Furthermore, ILC3s are also involved in the recognition and response to pathogens, and their dysfunction has been implicated in the development of severe infections, including sepsis and tuberculosis. The study of ILC3s has also highlighted the importance of the innate immune system in the prevention of infectious diseases, and has provided new insights into the development of novel vaccines and treatments for these diseases. In conclusion, the Group 3 Innate Lymphoid Cell is a critical component of the innate immune system, and its dysfunction has been implicated in a range of immune-mediated disorders. Further research into the biology and function of ILC3s is necessary to fully understand their role in immune homeostasis and to develop novel therapeutic strategies for the treatment of immune-related disorders.