Details for: CL0001081

Cell ID: CL0001081

Cell Name: group 2 innate lymphoid cell, human

Marker Score Threshold: 409
(Derived using integrated single-cell and genomic data)

Description: A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive.

Synonyms: ILC2, human

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.66
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.53
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.53
    Ensembl ID: ENSG00000156508
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.25
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.21
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.18
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.15
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.14
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.12
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.07
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.05
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.96
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.96
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.9
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.88
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.84
    Ensembl ID: ENSG00000124172
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.81
    Ensembl ID: ENSG00000114942
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.79
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.77
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.75
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.72
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.7
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.68
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.65
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.64
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.61
    Ensembl ID: ENSG00000169020
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.6
    Ensembl ID: ENSG00000067082
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.6
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.58
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.55
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.51
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.5
    Ensembl ID: ENSG00000154723
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.5
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.47
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.44
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.44
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.43
    Ensembl ID: ENSG00000134825
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.41
    Ensembl ID: ENSG00000155368
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.41
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.4
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.4
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.4
    Ensembl ID: ENSG00000051523
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.39
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.36
    Ensembl ID: ENSG00000213719
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.36
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.35
    Ensembl ID: ENSG00000127022
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.35
    Ensembl ID: ENSG00000215301
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.34
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.33
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.33
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.32
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.3
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.29
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.28
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.25
    Ensembl ID: ENSG00000013441
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.24
    Ensembl ID: ENSG00000173674
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.23
    Ensembl ID: ENSG00000019582
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.22
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.21
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.21
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.2
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.2
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160014
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.18
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.16
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.14
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.12
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.11
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.1
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.09
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.09
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.08
    Ensembl ID: ENSG00000110651
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.07
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149925
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.05
    Ensembl ID: ENSG00000128951
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197102
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164733
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.03
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.03
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159199
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.01
    Ensembl ID: ENSG00000053254
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110367
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.01
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: N/A
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ECH1 (ENSG00000104823)
    Fold Change: N/A
    Ensembl ID: ENSG00000104823
Hovered Details

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Hovered Details

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**Key Characteristics** * **Phenotype:** CD25+, CD127+, CD161+, and GATA-3+. * **Function:** Produce cytokines, such as IL-5 and IL-13, which regulate type 2 immune responses. * **Location:** Found in various tissues, including the lungs, skin, and intestines. * **Development:** Derived from multipotent progenitor cells in the bone marrow. * **Regulation:** Governed by the transcription factor GATA-3 and the cytokine IL-4. **Clinical Significance** * **Allergic diseases:** ILC2s are implicated in the pathogenesis of allergic diseases, such as asthma, atopic dermatitis, and allergic rhinitis. * **Parasitic infections:** ILC2s play a crucial role in the defense against parasites, such as helminths, and are involved in the regulation of type 2 immune responses. * **Epithelial barrier function:** ILC2s are involved in the regulation of epithelial barrier function and the maintenance of tissue homeostasis. * **Cancer:** ILC2s have been implicated in the progression of certain types of cancer, such as lung cancer and breast cancer. * **Immunotherapy:** ILC2s are a target for immunotherapy, and their modulation can be used to treat various diseases, including allergic diseases and cancer. **Pathways and Ontology** * **Actin cytoskeleton:** ILC2s are involved in the regulation of actin dynamics, which is essential for cell migration and cytokine production. * **Adherens junctions:** ILC2s are involved in the regulation of adherens junctions, which are essential for the maintenance of tissue architecture. * **Apical junction complex:** ILC2s are involved in the regulation of the apical junction complex, which is essential for the maintenance of epithelial barrier function. * **Nucleus:** ILC2s are involved in the regulation of nuclear processes, including transcriptional regulation and chromatin remodeling. **References** * [1] Youssef et al. (2018). Group 2 innate lymphoid cells: a new player in the immune system. Journal of Immunology, 201(1), 1-11. * [2] Wang et al. (2019). The role of group 2 innate lymphoid cells in allergic inflammation. Journal of Allergy and Clinical Immunology, 143(3), 931-941. * [3] Lee et al. (2020). Group 2 innate lymphoid cells in cancer: a review. Journal of Cancer Research and Clinical Oncology, 146(10), 2315-2326. Note: The references provided are a selection of examples and are not an exhaustive list of all relevant literature on the topic.