Details for: CL0002010

Cell ID: CL0002010

Cell Name: pre-conventional dendritic cell

Marker Score Threshold: 296
(Derived using integrated single-cell and genomic data)

Description: A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.34
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.83
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.83
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.81
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.77
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.66
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.65
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.5
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.49
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.35
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.33
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.21
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.2
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.17
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.16
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.15
    Ensembl ID: ENSG00000135940
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.12
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.05
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.04
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.99
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.93
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.9
    Ensembl ID: ENSG00000111775
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.89
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.87
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.84
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.84
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.75
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.71
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.7
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.69
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.64
    Ensembl ID: ENSG00000213719
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.64
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.62
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.62
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.57
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.57
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.53
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.51
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165629
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.44
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.41
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.41
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.36
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.36
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.36
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.36
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.35
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.32
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.31
    Ensembl ID: ENSG00000110651
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.29
    Ensembl ID: ENSG00000141522
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.28
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.23
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.21
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.2
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.2
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.19
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.13
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.12
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.11
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.11
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.11
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.1
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.09
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.09
    Ensembl ID: ENSG00000175416
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.08
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.06
    Ensembl ID: ENSG00000141367
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122218
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.05
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.05
    Ensembl ID: ENSG00000085063
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.04
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.04
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.03
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
Hovered Details

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Hovered Details

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**Key Characteristics** * Lin-negative: This indicates that the cell is not a lineage-positive cell, meaning it does not express markers associated with myeloid or lymphoid lineage cells. * MHC-II-negative: Dendritic cells are typically MHC-II-positive, but pre-conventional dendritic cells are MHC-II-negative, indicating that they have not yet matured. * CD11c-positive: CD11c is a surface marker commonly expressed on dendritic cells and other myeloid cells. * FLT3-positive: FLT3 is a receptor tyrosine kinase that plays a role in the development and function of hematopoietic cells, including dendritic cells. * Intermediate expression of SIRP-alpha: SIRP-alpha is a protein involved in the regulation of dendritic cell function and is often expressed at intermediate levels in pre-conventional dendritic cells. **Clinical Significance** Pre-conventional dendritic cells are of interest in the study of immune responses and the development of vaccines. These cells are thought to play a role in the initiation of immune responses by presenting antigens to naive T-cells. Understanding the function and development of pre-conventional dendritic cells may provide insights into the mechanisms of immune tolerance and the development of novel immunotherapies. In addition, pre-conventional dendritic cells may have implications for the treatment of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where the immune system attacks healthy tissues. Targeting pre-conventional dendritic cells may provide a novel approach to modulating the immune response and preventing tissue damage. Overall, the study of pre-conventional dendritic cells has the potential to advance our understanding of the immune system and the development of novel therapies for immune-related diseases. **Genes and Pathways** The cell described in this entry has a number of genes and pathways associated with immune function, including: * ACTB (Gene Symbol: ACTB, Ensembl ID: ENSG00000075624): ACTB is a gene involved in the regulation of immune responses and is often expressed in immune cells. * B2M (Gene Symbol: B2M, Ensembl ID: ENSG00000166710): B2M is a gene involved in the regulation of immune responses and is often expressed in immune cells. * Pathways: The cell described in this entry is involved in a number of pathways, including: + Actin cytoskeleton + Actin filament + Adherens junction + Adherens junction assembly + Adherens junctions interactions + Apical junction complex + Apical protein localization + Atp binding + Axon + Axon guidance + Axonogenesis + B-wich complex positively regulates rrna expression + Bbaf complex + Blood microparticle + Brahma complex + Brush border + Calyx of held + Cell-cell communication + Cell-cell junction + Cell-cell junction organization + Cell-extracellular matrix interactions + Cell junction organization + Cell motility + Cellular response to cytochalasin b + Chaperonin-mediated protein folding + Chromatin + Chromatin modifying enzymes + Chromatin organization + Chromatin remodeling + Clathrin-mediated endocytosis + Cooperation of prefoldin and tric/cct in actin and tubulin folding + Cortical cytoskeleton + Cytoplasm + Cytoplasmic ribonucleoprotein granule + Cytoskeleton + Cytosol + Dense body + Deubiquitination + Developmental biology + Disease + Diseases of signal transduction by growth factor receptors and second messengers + Dna damage recognition in gg-ner + Dna repair + Eph-ephrin mediated repulsion of cells + Eph-ephrin signaling + Ephb-mediated forward signaling + Epigenetic regulation of gene expression + Establishment or maintenance of cell polarity + Extracellular exosome + Extracellular space + Factors involved in megakaryocyte development and platelet production + Fcgamma receptor (fcgr) dependent phagocytosis + Fcgr3a-mediated phagocytosis + Focal adhesion + Folding of actin by cct/tric + Formation of annular gap junctions + Gap junction degradation + Gap junction trafficking + Gap junction trafficking and regulation + Gbaf complex + Gene expression (transcription) + Global genome nucleotide excision repair (gg-ner) + Glutamatergic synapse + Hats acetylate histones + Hemostasis + Hydrolase activity + Identical protein binding + Immune system + Infectious disease + Innate immune system + Interaction between l1 and ankyrins + Kinesin binding + Kinetochore + L1cam interactions + Lamellipodium + Leishmania infection + Leishmania phagocytosis + Maintenance of blood-brain barrier + Map2k and mapk activation + Mapk1/mapk3 signaling + Mapk family signaling cascades + Membrane + Membrane trafficking + Metabolism of proteins + Morphogenesis of a polarized epithelium + Nbaf complex + Negative regulation of cell differentiation + Negative regulation of protein binding + Nervous system development + Nitric-oxide synthase binding + Npbaf complex + Nua4 histone acetyltransferase complex + Nuclear matrix + Nucleoplasm + Nucleosomal dna binding + Nucleosome + Nucleotide excision repair + Nucleus + Oncogenic mapk signaling + Paradoxical activation of raf signaling by kinase inactive braf + Parasite infection + Parasitic infection pathways + Plasma membrane + Platelet aggregation + Positive epigenetic regulation of rrna expression + Positive regulation of cell differentiation + Positive regulation of cell population proliferation + Positive regulation of dna-templated transcription + Positive regulation of double-strand break repair + Positive regulation of double-strand break repair via homologous recombination + Positive regulation of myoblast differentiation + Positive regulation of norepinephrine uptake + Positive regulation of stem cell population maintenance + Positive regulation of t cell differentiation + Post-translational protein modification + Postsynaptic actin cytoskeleton + Postsynaptic actin cytoskeleton organization + Prefoldin mediated transfer of substrate to cct/tric + Presynapse + Protein-containing complex + Protein binding + Protein folding + Protein kinase binding + Protein localization to adherens junction + Raf/map kinase cascade + Recycling pathway of l1 + Regulation of actin dynamics for phagocytic cup formation + Regulation of apoptotic process + Regulation of cell cycle + Regulation of cyclin-dependent protein serine/threonine kinase activity + Regulation of double-strand break repair + Regulation of g0 to g1 transition + Regulation of g1/s transition of mitotic cell cycle + Regulation of mitotic metaphase/anaphase transition + Regulation of norepinephrine uptake + Regulation of nucleotide-excision repair + Regulation of protein localization to plasma membrane + Regulation of synaptic vesicle endocytosis + Regulation of transcription by rna polymerase ii + Regulation of transepithelial transport + Regulation of transmembrane transporter activity + Rhof gtpase cycle + Rho gtpase cycle + Rho gtpase effectors + Rho gtpases activate formins + Rho gtpases activate iqgaps + Rho gtpases activate wasps and waves + Ribonucleoprotein complex + Rsc-type complex + Schaffer collateral - ca1 synapse + Sensory perception + Sensory processing of sound + Sensory processing of sound by inner hair cells of the cochlea + Sensory processing of sound by outer hair cells of the cochlea + Signaling by braf and raf1 fusions + Signaling by high-kinase activity braf mutants + Signaling by moderate kinase activity braf mutants + Signaling by raf1 mutants + Signaling by ras mutants + Signaling by receptor tyrosine kinases + Signaling by