Details for: CL0002038

Cell ID: CL0002038

Cell Name: T follicular helper cell

Marker Score Threshold: 831
(Derived using integrated single-cell and genomic data)

Description: A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production.

Synonyms: T(FH), Tfh, follicular B helper T cell, follicular T cell, follicular T-cell, follicular T-helper cell, follicular helper T cell, follicular helper T-cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.79
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.49
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.47
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.46
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.36
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.29
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.98
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.91
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.88
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.78
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.56
    Ensembl ID: ENSG00000167286
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.55
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.55
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.54
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.51
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.5
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.46
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.38
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.38
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.38
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.37
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.32
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.32
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.3
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.26
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.25
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.21
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.13
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.07
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.02
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.97
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.92
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.9
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.88
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.87
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.86
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.82
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.8
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.77
    Ensembl ID: ENSG00000185883
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.74
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.74
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.7
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.68
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.68
    Ensembl ID: ENSG00000110848
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.66
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.63
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.63
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.6
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.59
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.57
    Ensembl ID: ENSG00000160654
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.57
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.55
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.53
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.46
    Ensembl ID: ENSG00000139193
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.45
    Ensembl ID: ENSG00000122545
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.44
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.43
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.42
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130303
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.38
    Ensembl ID: ENSG00000132965
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.35
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.34
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.34
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.34
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.32
    Ensembl ID: ENSG00000149311
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.31
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.31
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.3
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.29
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.27
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.24
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.23
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.23
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.22
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.17
    Ensembl ID: ENSG00000198821
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104765
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD40LG (ENSG00000102245)
    Fold Change: 1.11
    Ensembl ID: ENSG00000102245
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.11
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.08
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.07
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.04
    Ensembl ID: ENSG00000135046
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.03
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.03
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.02
    Ensembl ID: ENSG00000140299
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD4+ alpha-beta T cells**: Tfh cells are a subset of CD4+ T cells, which are a type of T cell that plays a central role in the adaptive immune response. 2. **CXCR5-positive, CCR7-negative**: Tfh cells express the chemokine receptor CXCR5, which is involved in the homing of T cells to lymphoid tissues, and are negative for the chemokine receptor CCR7, which is involved in the homing of T cells to peripheral tissues. 3. **BCL6-high, ICOS-high, PD1-high**: Tfh cells express high levels of the transcription factor BCL6, the costimulatory molecule ICOS, and the inhibitory receptor PD1. 4. **Follicular B cells**: Tfh cells interact with follicular B cells, which are B cells that are present in the germinal centers of lymphoid follicles. 5. **Class-switching and antibody production**: Tfh cells stimulate follicular B cells to undergo class-switching, which is the process by which B cells change the type of antibody they produce, and antibody production. **Clinical Significance** 1. **Autoimmune diseases**: Tfh cells have been implicated in the pathogenesis of various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Inflammatory diseases**: Tfh cells have also been implicated in the pathogenesis of inflammatory diseases, including asthma and inflammatory bowel disease. 3. **Immunotherapy**: Tfh cells are a potential target for immunotherapy, as they play a crucial role in the development of humoral immunity. 4. **Vaccine development**: Tfh cells are also a potential target for vaccine development, as they are involved in the development of immune responses to antigens. 5. **Cancer immunology**: Tfh cells have been implicated in the development of cancer immune responses, and may play a role in the development of cancer immunotherapies. In conclusion, T follicular helper cells are a specialized subset of CD4+ alpha-beta T cells that play a crucial role in the adaptive immune system. Their unique characteristics, including the expression of high levels of BCL6, ICOS, and PD1, make them an essential component of the germinal center reaction, which is the site of class-switching and antibody production. The clinical significance of Tfh cells is evident in their involvement in the pathogenesis of autoimmune and inflammatory diseases, and they may also play a role in the development of immunotherapies and vaccines.