Cell ID: CL0002038

Cell Name: T follicular helper cell

CSI Thresholds:

Select	Context	Threshold
	Overall	10.6032
	Omentum	98.2856
	Caecum + Healthy	59.2643
	Thoracic lymph node + Healthy	50.6418
	Thoracic lymph node	50.6390
	Nasal cavity + COVID-19	45.8346
	Omentum + Healthy	43.7942
	Nasal cavity + Healthy	43.1760
	Tonsil	39.7742
	Tonsil + Healthy	39.4365
	Bone marrow + Healthy	35.3604
	Nasal cavity	26.2356
	Transverse colon	26.0282
	Duodenum + Healthy	25.2737
	Duodenum	25.2195
	Ileum	22.8758
	Blood	22.5026
	Mesenteric lymph node	19.2027
	Mesenteric lymph node + Healthy	19.1648
	Crohn disease	16.3343
	Sigmoid colon	15.9474
	Lymph node	15.5587
	Ileum + Crohn disease	14.6483
	Liver + Healthy	14.5229
	Blood + COVID-19	13.2806
	Respiratory system disorder	13.2295
	Blood + Respiratory system disorder	13.2044
	Liver	11.1836
	Small intestine	9.3747
	Blood + Healthy	9.0733
	Healthy	8.5899
	Lung	8.1693
	Bone marrow	7.4557
	Follicular lymphoma	6.7649
	Lymph node + Follicular lymphoma	6.7649
	Caecum	6.3159
	COVID-19	5.8904
	Lymph node + Healthy	5.7491
	Thymus	4.6504
	Thymus + Healthy	4.6423
	Small intestine + Healthy	3.4754
	Sigmoid colon + Healthy	2.7223
	Trachea	2.6856
	Lung + Healthy	2.4953
	Trachea + Healthy	1.7559
	Spleen	1.6939
	Spleen + Healthy	1.6864
	Lymph node + Metastatic melanoma	1.4242
	Metastatic melanoma	1.4241
	Skeletal muscle tissue + Healthy	0.6858
	Skeletal muscle tissue	0.6842
	Lamina propria	0.6136
	Lamina propria + Healthy	0.6101
	Jejunal epithelium	0.2574
	Jejunal epithelium + Healthy	0.2552
	Transverse colon + Healthy	-6.7175
	Ileum + Healthy	-51.6655

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production.

Synonyms: T(FH), Tfh, follicular B helper T cell, follicular T cell, follicular T-cell, follicular T-helper cell, follicular helper T cell, follicular helper T-cell