Details for: CL0002046

Cell ID: CL0002046

Cell Name: early pro-B cell

Marker Score Threshold: 10134
(Derived using integrated single-cell and genomic data)

Description: A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.08
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.07
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.96
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.92
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.89
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.89
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.87
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.86
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.81
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.76
    Ensembl ID: ENSG00000104964
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.75
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.64
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.5
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.48
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.46
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 2.44
    Ensembl ID: ENSG00000110987
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.43
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.41
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.36
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.35
    Ensembl ID: ENSG00000154518
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.35
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.31
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.29
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.27
    Ensembl ID: ENSG00000130303
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 2.25
    Ensembl ID: ENSG00000108561
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.23
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.22
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.22
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.22
    Ensembl ID: ENSG00000128272
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.16
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.11
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.08
    Ensembl ID: ENSG00000137845
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 2.04
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.01
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.99
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.98
    Ensembl ID: ENSG00000089820
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.97
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.96
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.94
    Ensembl ID: ENSG00000136573
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.9
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.86
    Ensembl ID: ENSG00000087274
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.86
    Ensembl ID: ENSG00000121410
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.83
    Ensembl ID: ENSG00000149823
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.79
    Ensembl ID: ENSG00000134825
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.72
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.7
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.7
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.7
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: 1.68
    Ensembl ID: ENSG00000196839
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.64
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.59
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.57
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.53
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.51
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.51
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.51
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.44
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.41
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.38
    Ensembl ID: ENSG00000197894
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.36
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.36
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.36
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.35
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.34
    Ensembl ID: ENSG00000115307
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.33
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.32
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.3
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.29
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.29
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.29
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.25
    Ensembl ID: ENSG00000186716
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198356
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.22
    Ensembl ID: ENSG00000105221
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.21
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.2
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.2
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.19
    Ensembl ID: ENSG00000142208
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.18
    Ensembl ID: ENSG00000183255
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.16
    Ensembl ID: ENSG00000106624
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.16
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.15
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.14
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.13
    Ensembl ID: ENSG00000074370
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168421
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.1
    Ensembl ID: ENSG00000101444
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.04
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.02
    Ensembl ID: ENSG00000127837
Hovered Details

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Hovered Details

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**Key Characteristics** * **Surface markers**: CD22, CD34, CD38, TdT (terminal deoxynucleotidyl transferase) * **D-to-J recombination**: Occurs in the heavy chain of the B cell receptor * **Negative surface markers**: CD19, CD20, complement receptor type 2, CD10 * **Cell type**: Early pro-B cell * **Genetic makeup**: B2M (beta-2 microglobulin) gene, ACTG1 (actin gamma 1) gene, ACTB (actin beta) gene **Clinical Significance** * **B cell development**: The early pro-B cell is a critical stage in the development of B cells, which are essential for the adaptive immune response. * **Immunodeficiency**: Defects in B cell development, including the early pro-B cell stage, can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia. * **Cancer**: Dysregulation of B cell development, including the early pro-B cell stage, can contribute to the development of B cell malignancies, such as chronic lymphocytic leukemia (CLL). * **Autoimmune diseases**: Abnormalities in B cell development, including the early pro-B cell stage, can contribute to autoimmune diseases, such as autoimmune hemolytic anemia. * **Vaccine development**: Understanding the early pro-B cell stage is essential for the development of vaccines that target B cells and induce immune responses. **Pathways/Ontology** The early pro-B cell is associated with various signaling pathways, including: * **Adaptive immune system**: The early pro-B cell is a critical component of the adaptive immune response, which involves the activation of B cells and the production of antibodies. * **Amyloid fiber formation**: The early pro-B cell is associated with the formation of amyloid fibers, which are involved in various diseases, including Alzheimer's disease. * **Antigen presentation**: The early pro-B cell is involved in the presentation of antigens to T cells, which is essential for the activation of B cells and the induction of immune responses. * **Cytokine signaling**: The early pro-B cell is involved in cytokine signaling, which is essential for the regulation of immune responses and the development of B cells. Overall, the early pro-B cell is a critical component of the immune system, and its dysregulation can contribute to various diseases, including immunodeficiency, cancer, and autoimmune disorders.