Details for: CL0002062

Cell ID: CL0002062

Cell Name: type I pneumocyte

Marker Score Threshold: 1205
(Derived using integrated single-cell and genomic data)

Description: A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.

Synonyms: lung type 1 cells, membranous pneumocytes, pulmonary alveolar type I cell, small alveolar cells, squamous alveolar cell, squamous alveolar lining cell, type 1 alveolar epithelial cells, type 1 pneumocyte, type I alveolar cells, type I alveolar epithelial cells, type I pneumocyte, AT1, ATI

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AGER (ENSG00000204305)
    Fold Change: 5.55
    Ensembl ID: ENSG00000204305
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.6
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.57
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 4.48
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.1
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.96
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 3.91
    Ensembl ID: ENSG00000138772
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 3.67
    Ensembl ID: ENSG00000171885
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.67
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 3.37
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.32
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.15
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.09
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.97
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.88
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.73
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.69
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.64
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.62
    Ensembl ID: ENSG00000135390
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.54
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.53
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.46
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 2.31
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.27
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.22
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.17
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 2.09
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 2.07
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.05
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.02
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.02
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.02
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.99
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.97
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.91
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.77
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.76
    Ensembl ID: ENSG00000169252
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.76
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALDH3B1 (ENSG00000006534)
    Fold Change: 1.74
    Ensembl ID: ENSG00000006534
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.74
    Ensembl ID: ENSG00000102554
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.74
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.72
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.7
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.68
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.65
    Ensembl ID: ENSG00000152234
  • Gene Symbol: MYRF (ENSG00000124920)
    Fold Change: 1.64
    Ensembl ID: ENSG00000124920
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.64
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.62
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.6
    Ensembl ID: ENSG00000106546
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.56
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.56
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.55
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.54
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.49
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.45
    Ensembl ID: ENSG00000058668
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.42
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.37
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.37
    Ensembl ID: ENSG00000141522
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.36
    Ensembl ID: ENSG00000123838
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.35
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.33
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.33
    Ensembl ID: ENSG00000156110
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.31
    Ensembl ID: ENSG00000204580
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.31
    Ensembl ID: ENSG00000197894
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.28
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.28
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.24
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.24
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.21
    Ensembl ID: ENSG00000240583
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.18
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.18
    Ensembl ID: ENSG00000071553
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.16
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.15
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.15
    Ensembl ID: ENSG00000176171
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.14
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.11
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.09
    Ensembl ID: ENSG00000002330
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.08
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.07
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.05
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.05
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.05
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137486
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Flattened and branched morphology**: Type I pneumocytes have a flattened and branched morphology, with thin cytoplasmic extensions that form the air-blood barrier. 2. **Thin cytoplasmic extensions**: The cytoplasmic extensions of type I pneumocytes are thin (50-100 nm), allowing for efficient gas exchange. 3. **High surface area**: Type I pneumocytes cover over 98% of the alveolar surface, making them the most abundant cell type in the alveolar epithelium. 4. **Involvement in inflammatory responses**: Type I pneumocytes are involved in the regulation of inflammatory responses, including the production of cytokines and chemokines. 5. **Involvement in immune responses**: Type I pneumocytes are also involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 6. **Response to hypoxia**: Type I pneumocytes are sensitive to hypoxia and play a crucial role in the regulation of the response to low oxygen levels. **Clinical Significance** 1. **Pulmonary fibrosis**: Type I pneumocytes are involved in the development of pulmonary fibrosis, a condition characterized by the scarring of lung tissue. 2. **Acute respiratory distress syndrome (ARDS)**: Type I pneumocytes are involved in the development of ARDS, a condition characterized by inflammation and injury to the lung tissue. 3. **Chronic obstructive pulmonary disease (COPD)**: Type I pneumocytes are involved in the development of COPD, a condition characterized by chronic inflammation and airflow limitation. 4. **Pulmonary hypertension**: Type I pneumocytes are involved in the development of pulmonary hypertension, a condition characterized by high blood pressure in the lungs. 5. **Infectious diseases**: Type I pneumocytes are involved in the regulation of the response to infectious diseases, including respiratory viruses and bacteria. In conclusion, type I pneumocytes are a specialized cell type that plays a crucial role in the regulation of inflammatory responses, immune responses, and the response to hypoxia. Their dysregulation has been implicated in various pulmonary diseases, including pulmonary fibrosis, ARDS, COPD, pulmonary hypertension, and infectious diseases.