Cell ID: CL0002063

Cell Name: pulmonary alveolar type 2 cell

CSI Thresholds:

Select	Context	Threshold
	Overall	8.2713
	Alveolus of lung + Healthy	527.5514
	Pulmonary emphysema	476.8397
	Alveolus of lung + Pulmonary emphysema	476.8329
	Alveolus of lung	369.2314
	Lung + Lymphangioleiomyomatosis	138.4771
	Lymphangioleiomyomatosis	138.4728
	Alveolar sac + Healthy	119.0148
	Alveolar sac	119.0082
	Lung parenchyma + Healthy	56.3787
	Hypersensitivity pneumonitis	47.5424
	Lung + Hypersensitivity pneumonitis	47.5416
	Lung adenocarcinoma	46.7703
	Upper lobe of left lung + Healthy	43.4547
	Upper lobe of left lung	43.4501
	Uterus	32.4410
	Respiratory airway	30.1969
	Respiratory airway + Healthy	30.1115
	Uterus + Healthy	25.6234
	Lung + Interstitial lung disease	23.2244
	Interstitial lung disease	23.2226
	Pulmonary sarcoidosis	22.5169
	Lung + Pulmonary sarcoidosis	22.5111
	Lung parenchyma	21.1051
	Anencephaly	20.0909
	Lung + Anencephaly	20.0909
	Cystic fibrosis	20.0531
	Lung + Cystic fibrosis	19.9416
	Lymph node	18.8026
	Lung parenchyma + Chronic obstructive pulmonary disease	18.0523
	Lower lobe of left lung	15.2936
	Lower lobe of left lung + Healthy	15.2858
	Lung + Pleomorphic carcinoma	13.8319
	Pleomorphic carcinoma	13.8256
	Lung + Healthy	13.1503
	Lung + COVID-19	11.5602
	Chronic obstructive pulmonary disease	10.4831
	COVID-19	10.0634
	Brain	8.8237
	Non-specific interstitial pneumonia	8.5268
	Lung + Non-specific interstitial pneumonia	8.5206
	Healthy	7.0812
	Lung + Lung adenocarcinoma	6.4014
	Lung + Lung large cell carcinoma	5.5252
	Lung large cell carcinoma	5.5206
	Lung	4.9783
	Nose + Chronic rhinitis	4.7786
	Chronic rhinitis	4.7365
	Brain + Lung adenocarcinoma	4.6935
	Lymph node + Lung adenocarcinoma	4.6433
	Nose	4.5491
	Non-small cell lung carcinoma	4.4085
	Lung + Non-small cell lung carcinoma	4.4074
	Lung + Squamous cell lung carcinoma	4.1128
	Squamous cell lung carcinoma	4.0947
	Pulmonary fibrosis	3.4755
	Lung + Pulmonary fibrosis	3.4730
	Bronchus	3.3819
	Bronchus + Healthy	3.3721
	Lung + Pneumonia	3.2116
	Pneumonia	3.2081
	Lung + Chronic obstructive pulmonary disease	2.4319

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.

Synonyms: cuboidal type II cell, granular pneumocyte, great alveolar cell, lung type 2 cell, type 2 alveolar epithelial cell, type 2 alveolocyte, type 2 pneumocyte, type II alveolar cell, type II alveolar epithelial cell, type II alveolocyte, type II pneumocyte, AT2, ATII, TII, lung type II cell