Details for: CL0002063

Cell ID: CL0002063

Cell Name: type II pneumocyte

Marker Score Threshold: 6,518
(Derived using integrated single-cell and genomic data)

Description: A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.

Synonyms: cuboidal type II cell, granular pneumocyte, great alveolar cell, lung type 2 cell, type 2 alveolar epithelial cell, type 2 alveolocyte, type 2 pneumocyte, type II alveolar cell, type II alveolar epithelial cell, type II alveolocyte, type II pneumocyte, AT2, ATII, TII, lung type II cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.57
    Ensembl ID: ENSG00000169100
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 4.24
    Ensembl ID: ENSG00000087086
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.12
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 4.08
    Ensembl ID: ENSG00000156508
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 4.03
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 4
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.9
    Ensembl ID: ENSG00000149806
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.85
    Ensembl ID: ENSG00000132475
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 3.84
    Ensembl ID: ENSG00000084207
  • Gene Symbol: HLA DRA (ENSG00000204287)
    Fold Change: 3.81
    Ensembl ID: ENSG00000204287
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.8
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.78
    Ensembl ID: ENSG00000135404
  • Gene Symbol: DLX5 (ENSG00000105880)
    Fold Change: 3.77
    Ensembl ID: ENSG00000105880
  • Gene Symbol: CTSH (ENSG00000103811)
    Fold Change: 3.73
    Ensembl ID: ENSG00000103811
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 3.72
    Ensembl ID: ENSG00000160213
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3.72
    Ensembl ID: ENSG00000168028
  • Gene Symbol: C2 (ENSG00000166278)
    Fold Change: 3.72
    Ensembl ID: ENSG00000166278
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.72
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 3.71
    Ensembl ID: ENSG00000166347
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 3.63
    Ensembl ID: ENSG00000155368
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.61
    Ensembl ID: ENSG00000184009
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.58
    Ensembl ID: ENSG00000189403
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 3.58
    Ensembl ID: ENSG00000101439
  • Gene Symbol: FABP5 (ENSG00000164687)
    Fold Change: 3.57
    Ensembl ID: ENSG00000164687
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 3.54
    Ensembl ID: ENSG00000167658
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 3.53
    Ensembl ID: ENSG00000163041
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 3.53
    Ensembl ID: ENSG00000162551
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.51
    Ensembl ID: ENSG00000108654
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 3.47
    Ensembl ID: ENSG00000169567
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.47
    Ensembl ID: ENSG00000131143
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 3.46
    Ensembl ID: ENSG00000104529
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 3.44
    Ensembl ID: ENSG00000167468
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 3.44
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.42
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.37
    Ensembl ID: ENSG00000163399
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 3.36
    Ensembl ID: ENSG00000234745
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 3.35
    Ensembl ID: ENSG00000096384
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.34
    Ensembl ID: ENSG00000145741
  • Gene Symbol: HLA DRB1 (ENSG00000196126)
    Fold Change: 3.34
    Ensembl ID: ENSG00000196126
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.31
    Ensembl ID: ENSG00000080824
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 3.3
    Ensembl ID: ENSG00000111775
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.29
    Ensembl ID: ENSG00000111640
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 3.28
    Ensembl ID: ENSG00000114942
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.27
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 3.26
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.23
    Ensembl ID: ENSG00000143933
  • Gene Symbol: HLA DPB1 (ENSG00000223865)
    Fold Change: 3.22
    Ensembl ID: ENSG00000223865
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 3.19
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 3.18
    Ensembl ID: ENSG00000135486
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 3.18
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.18
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 3.18
    Ensembl ID: ENSG00000167972
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 3.17
    Ensembl ID: ENSG00000176340
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 3.17
    Ensembl ID: ENSG00000206503
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 3.16
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.16
    Ensembl ID: ENSG00000099622
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 3.16
    Ensembl ID: ENSG00000170345
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.16
    Ensembl ID: ENSG00000122566
  • Gene Symbol: LDHB (ENSG00000111716)
    Fold Change: 3.15
    Ensembl ID: ENSG00000111716
  • Gene Symbol: HLA DPA1 (ENSG00000231389)
    Fold Change: 3.14
    Ensembl ID: ENSG00000231389
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 3.11
    Ensembl ID: ENSG00000221869
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 3.1
    Ensembl ID: ENSG00000135940
  • Gene Symbol: LGALS3 (ENSG00000131981)
    Fold Change: 3.09
    Ensembl ID: ENSG00000131981
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.09
    Ensembl ID: ENSG00000172757
  • Gene Symbol: GNG5 (ENSG00000174021)
    Fold Change: 3.08
    Ensembl ID: ENSG00000174021
  • Gene Symbol: CXCL2 (ENSG00000081041)
    Fold Change: 3.07
    Ensembl ID: ENSG00000081041
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 3.07
    Ensembl ID: ENSG00000134825
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 3.04
    Ensembl ID: ENSG00000177606
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 3.02
    Ensembl ID: ENSG00000123838
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 3.02
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.99
    Ensembl ID: ENSG00000067560
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.98
    Ensembl ID: ENSG00000204525
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.95
    Ensembl ID: ENSG00000090013
  • Gene Symbol: DHCR24 (ENSG00000116133)
    Fold Change: 2.95
    Ensembl ID: ENSG00000116133
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 2.95
    Ensembl ID: ENSG00000106211
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 2.93
    Ensembl ID: ENSG00000104408
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 2.93
    Ensembl ID: ENSG00000106992
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 2.91
    Ensembl ID: ENSG00000131174
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.89
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.87
    Ensembl ID: ENSG00000185650
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.85
    Ensembl ID: ENSG00000120129
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.85
    Ensembl ID: ENSG00000205581
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.84
    Ensembl ID: ENSG00000087460
  • Gene Symbol: CPM (ENSG00000135678)
    Fold Change: 2.8
    Ensembl ID: ENSG00000135678
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 2.8
    Ensembl ID: ENSG00000110321
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 2.77
    Ensembl ID: ENSG00000171223
  • Gene Symbol: JUND (ENSG00000130522)
    Fold Change: 2.76
    Ensembl ID: ENSG00000130522
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.74
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.71
    Ensembl ID: ENSG00000179218
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.7
    Ensembl ID: ENSG00000165119
  • Gene Symbol: KRT18 (ENSG00000111057)
    Fold Change: 2.68
    Ensembl ID: ENSG00000111057
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.66
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.65
    Ensembl ID: ENSG00000182718
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 2.65
    Ensembl ID: ENSG00000198830

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in type II pneumocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in type II pneumocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Cuboidal shape**: Type II pneumocytes are characterized by their cuboidal shape, which allows them to maintain a large surface area in contact with the alveolar space. * **Rounded apical surface**: The apical surface of Type II pneumocytes is rounded, which enables them to secrete surfactants and other substances into the alveolar space. * **Short microvilli**: The free surface of Type II pneumocytes is covered by short microvilli, which increase the surface area for surfactant secretion. * **Ability to differentiate into Type I pneumocytes**: After injury, Type II pneumocytes have the ability to differentiate into Type I pneumocytes, which is essential for tissue repair. * **Surfactant secretion and recycling**: Type II pneumocytes are responsible for secreting and recycling surfactants, which helps to reduce surface tension in the alveolar space. **Clinical Significance** * **Respiratory diseases**: Type II pneumocytes play a crucial role in maintaining lung function, and their dysfunction can contribute to various respiratory diseases such as acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. * **Surfactant deficiency**: Deficiencies in surfactant production or function can lead to respiratory distress, especially in premature infants. * **Infection and inflammation**: Type II pneumocytes can contribute to the development of infection and inflammation in the lungs, which can lead to various diseases such as pneumonia and bronchiolitis. * **Cancer**: The ability of Type II pneumocytes to differentiate into Type I pneumocytes has been implicated in the development of lung cancer, particularly in the context of chronic inflammation and oxidative stress. In conclusion, Type II pneumocytes are essential cells in the respiratory system, and their dysfunction can contribute to various respiratory diseases. Understanding the characteristics and clinical significance of these cells is crucial for developing effective treatments for respiratory diseases.