Details for: CL0002063

Cell ID: CL0002063

Cell Name: type II pneumocyte

Marker Score Threshold: 6518
(Derived using integrated single-cell and genomic data)

Description: A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.

Synonyms: cuboidal type II cell, granular pneumocyte, great alveolar cell, lung type 2 cell, type 2 alveolar epithelial cell, type 2 alveolocyte, type 2 pneumocyte, type II alveolar cell, type II alveolar epithelial cell, type II alveolocyte, type II pneumocyte, AT2, ATII, TII, lung type II cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.57
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.12
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.61
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 3.53
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.37
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 3.18
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.18
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 3.18
    Ensembl ID: ENSG00000167972
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 3.02
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.99
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 2.93
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.66
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.65
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.65
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.64
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.59
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.55
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.53
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.49
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.44
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.42
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.38
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.34
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.31
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.31
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.24
    Ensembl ID: ENSG00000156110
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 2.17
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.16
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.12
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.1
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.1
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.99
    Ensembl ID: ENSG00000171885
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.95
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.92
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.91
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.9
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.9
    Ensembl ID: ENSG00000123505
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.87
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.87
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.84
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALOX15B (ENSG00000179593)
    Fold Change: 1.71
    Ensembl ID: ENSG00000179593
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.68
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.66
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.65
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.55
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.55
    Ensembl ID: ENSG00000107262
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.54
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.52
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.51
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.47
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.47
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.45
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.44
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.44
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.43
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.38
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.37
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.36
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.3
    Ensembl ID: ENSG00000106605
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.29
    Ensembl ID: ENSG00000004455
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.27
    Ensembl ID: ENSG00000147872
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.26
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.21
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.18
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.18
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.14
    Ensembl ID: ENSG00000006125
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.11
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.11
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.11
    Ensembl ID: ENSG00000004059
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.05
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.04
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.04
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142208
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060971
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.02
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.02
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1
    Ensembl ID: ENSG00000033627
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1
    Ensembl ID: ENSG00000060982
Hovered Details

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Hovered Details

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**Key Characteristics** - **Shape and Size**: Type II pneumocytes are cuboidal in shape and thicker than squamous alveolar cells. - **Apical Surface**: The apical surface of type II pneumocytes is rounded and projects above the level of surrounding epithelium. - **Microvilli**: The free surface of type II pneumocytes is covered by short microvilli. - **Function**: Type II pneumocytes secrete and recycle surfactants to maintain fluid balance around the alveolar epithelium and contribute to tissue repair. - **Differentiation**: Type II pneumocytes can differentiate into type I pneumocytes after injury. **Clinical Significance** - **Respiratory Diseases**: Type II pneumocytes are involved in the pathogenesis of various respiratory diseases, including acute respiratory distress syndrome (ARDS), pneumonia, and chronic obstructive pulmonary disease (COPD). - **Surfactant Deficiency**: Type II pneumocytes play a crucial role in surfactant production, and their dysfunction can lead to surfactant deficiency, a common cause of respiratory distress in preterm infants. - **Injury and Repair**: Type II pneumocytes are involved in tissue repair and can differentiate into type I pneumocytes after injury, which is essential for maintaining alveolar structure and function. - **Cancer**: Alterations in type II pneumocyte function have been implicated in the development of lung cancer. - **Infection**: Type II pneumocytes can interact with pathogens and play a role in the innate immune response. **Genetic and Molecular Characteristics** - **Gene Symbol**: SLC25A6 - **Ensembl ID**: ENSG00000169100 - **Pathways/Ontology**: Apoptotic process, Atp:adp antiporter activity, Disease, Hiv infection, Host interactions of hiv factors, Infectious disease, Influenza infection, Interactions of vpr with host cellular proteins, Membrane, Metabolism of proteins, Mitochondrial adp transmembrane transport, Mitochondrial atp transmembrane transport, Mitochondrial inner membrane, Mitochondrial protein degradation, Mitochondrial protein import, Mitochondrion, Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, Nucleus, Protein binding, Protein localization, Slc-mediated transmembrane transport, Tim23 mitochondrial import inner membrane translocase complex, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules, Viral infection pathways, Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization - **Gene Symbol**: B2M - **Ensembl ID**: ENSG00000166710 - **Pathways/Ontology**: Adaptive immune system, Amyloid fiber formation, Amyloid fibril formation, Antigen presentation: folding, assembly and peptide loading of class i mhc, Antigen processing-cross presentation, Antigen processing and presentation of endogenous peptide antigen via mhc class i, Antigen processing and presentation of exogenous peptide antigen via mhc class ii, Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent, Bacterial infection pathways, Cellular response to iron(iii) ion, Cellular response to iron ion, Cellular response to nicotine, Class i mhc mediated antigen processing & presentation, Cytokine signaling in immune system, Cytosol, Dap12 interactions, Dap12 signaling, Disease, Early endosome lumen, Early endosome membrane, Endoplasmic reticulum, Endoplasmic reticulum lumen, Endosomal/vacuolar pathway, Er-phagosome pathway, Er to golgi transport vesicle membrane, External side of plasma membrane, Extracellular exosome, Extracellular region, Extracellular space, Focal adhesion, Golgi apparatus, Golgi membrane, Hfe-transferrin receptor complex, Hiv infection, Host interactions of hiv factors, Identical protein binding, Immune system, Immunoregulatory interactions between a lymphoid and a non-lymphoid cell, Infection with mycobacterium tuberculosis, Infectious disease, Innate immune system, Interferon gamma signaling, Interferon signaling, Intracellular iron ion homeostasis, Iron ion transport, Late endosome membrane, Learning or memory, Lysosomal membrane, Membrane, Metabolism of proteins, Mhc class ii protein complex, Mhc class ii protein complex binding, Mhc class i peptide loading complex, Mhc class i protein complex, Modulation by mtb of host immune system, Multicellular organismal-level iron ion homeostasis, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Nef mediated downregulation of mhc class i complex cell surface expression, Negative regulation of epithelial cell proliferation, Negative regulation of forebrain neuron differentiation, Negative regulation of neurogenesis, Negative regulation of neuron projection development, Negative regulation of receptor binding, Neutrophil degranulation, Peptide antigen assembly with mhc class ii protein complex, Peptide antigen assembly with mhc class i protein complex, Peptide antigen binding, Phagocytic vesicle membrane, Plasma membrane, Positive regulation of cellular senescence, Positive regulation of ferrous iron binding, Positive regulation of immune response, Positive regulation of protein binding, Positive regulation of receptor-mediated endocytosis, Positive regulation of receptor binding, Positive regulation of t cell activation, Positive regulation of t cell cytokine production, Positive regulation of t cell mediated cytotoxicity, Positive regulation of transferrin receptor binding, Protein binding, Protein homodimerization activity, Protein homotetramerization, Protein refolding, Recycling endosome membrane, Regulation of erythrocyte differentiation, Regulation of iron ion transport, Response to molecule of bacterial origin, Sars-cov-2 activates/modulates innate and adaptive immune responses, Sars-cov-2 infection, Sars-cov-2-host interactions, Sars-cov infections, Sensory perception of smell, Specific granule lumen, Structural molecule activity, T cell differentiation in thymus, T cell mediated cytotoxicity, Tertiary granule lumen, The role of nef in hiv-1 replication and disease pathogenesis, Viral infection pathways - **Gene Symbol**: ACTB - **Ensembl ID**: ENSG00000075624 - **Pathways/Ontology**: Actin cytoskeleton, Actin filament, Adherens junction, Adherens junction assembly, Adherens junctions interactions, Apical junction complex, Apical protein localization, Atp binding, Axon, Axon guidance, Axonogenesis, B-wich complex positively regulates rrna expression, Bbaf complex, Blood microparticle, Brahma complex, Brush border, Calyx of held, Cell-cell communication, Cell-cell junction, Cell-cell junction organization, Cell-extracellular matrix interactions, Cell junction organization, Cell motility, Cellular response to cytochalasin b, Chaperonin-mediated protein folding, Chromatin, Chromatin modifying enzymes, Chromatin organization, Chromatin remodeling, Clathrin-mediated endocytosis, Cooperation of prefoldin and tric/cct in actin and tubulin folding, Cortical cytoskeleton, Cytoplasm, Cytoplasmic ribonucleoprotein granule, Cytoskeleton, Cytosol, Dense body, Deubiquitination, Developmental biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dna damage recognition in gg-ner, Dna repair, Eph-ephrin mediated repulsion of cells, Eph-ephrin signaling, Ephb-mediated forward signaling, Epigenetic regulation of gene expression, Establishment or maintenance of cell polarity, Extracellular exosome, Extracellular space, Factors involved in megakaryocyte development and platelet production, Fcgamma receptor (fcgr) dependent phagocytosis, Fcgr3a-mediated phagocytosis, Focal adhesion, Folding of actin by cct/tric, Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gbaf complex, Gene expression (transcription), Global genome nucleotide excision repair (gg-ner), Glutamatergic synapse, Hats acetylate histones, Hemostasis, Hydrolase activity, Identical protein binding, Immune system, Infectious disease, Innate immune system, Interaction between l1 and ankyrins, Kinesin binding, Kinetochore, L1cam interactions, Lamellipodium, Leishmania infection, Leishmania phagocytosis, Maintenance of blood-brain barrier, Map2k and mapk activation, Mapk1/mapk3 signaling, Mapk family signaling cascades, Membrane, Membrane trafficking, Metabolism of proteins, Morphogenesis of a polarized epithelium, Nbaf complex, Negative regulation of cell differentiation, Negative regulation of protein binding, Nervous system development, Nitric-oxide synthase binding, Npbaf complex, Nua4 histone acetyltransferase complex, Nuclear matrix, Nucleoplasm, Nucleosomal dna binding, Nucleosome