Details for: CL0002064

Cell ID: CL0002064

Cell Name: pancreatic acinar cell

Marker Score Threshold: 2111
(Derived using integrated single-cell and genomic data)

Description: A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.

Synonyms: acinar cell of pancreas

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 10.2
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 5.56
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 5.44
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 5.37
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 5.18
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 5.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 4.66
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 4.66
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 4.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 4.12
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 4.09
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 4.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 3.85
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 3.74
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 3.05
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.87
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.83
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 2.51
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.5
    Ensembl ID: ENSG00000075624
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 2.5
    Ensembl ID: ENSG00000240038
  • Gene Symbol: AMY2A (ENSG00000243480)
    Fold Change: 2.48
    Ensembl ID: ENSG00000243480
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.45
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 2.4
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.39
    Ensembl ID: ENSG00000163631
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.34
    Ensembl ID: ENSG00000166710
  • Gene Symbol: AQP8 (ENSG00000103375)
    Fold Change: 2.31
    Ensembl ID: ENSG00000103375
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.23
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 2.08
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.06
    Ensembl ID: ENSG00000170634
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198356
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.98
    Ensembl ID: ENSG00000130294
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.98
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.96
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ASNS (ENSG00000070669)
    Fold Change: 1.93
    Ensembl ID: ENSG00000070669
  • Gene Symbol: ARHGDIG (ENSG00000242173)
    Fold Change: 1.93
    Ensembl ID: ENSG00000242173
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.85
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.85
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.82
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.81
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.8
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.76
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.76
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.72
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.57
    Ensembl ID: ENSG00000138356
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.56
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.56
    Ensembl ID: ENSG00000075239
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.53
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.49
    Ensembl ID: ENSG00000120437
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.47
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.43
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.42
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.35
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.35
    Ensembl ID: ENSG00000101444
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.33
    Ensembl ID: ENSG00000095139
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.31
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ARSL (ENSG00000157399)
    Fold Change: 1.31
    Ensembl ID: ENSG00000157399
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.28
    Ensembl ID: ENSG00000006756
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.24
    Ensembl ID: ENSG00000110987
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.21
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.16
    Ensembl ID: ENSG00000120805
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196961
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.16
    Ensembl ID: ENSG00000101966
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.16
    Ensembl ID: ENSG00000105221
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.16
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.14
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.11
    Ensembl ID: ENSG00000090861
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105552
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.1
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142208
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.09
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACP2 (ENSG00000134575)
    Fold Change: 1.08
    Ensembl ID: ENSG00000134575
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.08
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.07
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.07
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.05
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.04
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.04
    Ensembl ID: ENSG00000090013
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.03
    Ensembl ID: ENSG00000121410
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.03
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.02
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.02
    Ensembl ID: ENSG00000111275
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ARSA (ENSG00000100299)
    Fold Change: 1
    Ensembl ID: ENSG00000100299
Hovered Details

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Hovered Details

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**Key Characteristics** * Secretory cells in the pancreas * Produce and secrete digestive enzymes and mucins * Basal nucleus and basophilic cytoplasm * Regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules * Involved in the digestive process * Can lead to various pancreatic disorders when dysfunctional **Clinical Significance** Pancreatic acinar cells play a critical role in the digestive process, and their dysfunction can lead to various pancreatic disorders, including: * Pancreatitis: inflammation of the pancreas, which can be acute or chronic * Pancreatic insufficiency: reduced production of digestive enzymes, leading to malabsorption and malnutrition * Diabetes mellitus: impaired insulin production, leading to hyperglycemia and metabolic disorders * Pancreatic cancer: malignant tumors that arise from pancreatic acinar cells * Chronic pancreatitis: recurring episodes of pancreatitis, leading to irreversible damage to pancreatic tissue Understanding the biology and function of pancreatic acinar cells is essential for the diagnosis and treatment of pancreatic disorders. Research on these cells can lead to the development of new therapeutic strategies and biomarkers for pancreatic diseases. **Genes Associated with Pancreatic Acinar Cells** Several genes are associated with pancreatic acinar cells, including: * SLC25A6: involved in the regulation of mitochondrial ATP production * ATP5MC2: involved in the formation of cristae in mitochondria * ATP5F1E: involved in the production of ATP through chemiosmosis * ATP5ME: involved in the regulation of mitochondrial biogenesis and function * ATP5F1D: involved in the regulation of mitochondrial biogenesis and function * ATP5PF: involved in the regulation of mitochondrial protein degradation and biogenesis * ATP5PO: involved in the regulation of ATP biosynthesis * ATP5MC3: involved in the regulation of lipid binding and metabolism * ATP5F1C: involved in the regulation of ATP biosynthesis and hydrolysis These genes play critical roles in the regulation of mitochondrial function, biogenesis, and protein degradation, which are essential for the proper functioning of pancreatic acinar cells. **Pathways Associated with Pancreatic Acinar Cells** Several pathways are associated with pancreatic acinar cells, including: * Apoptotic process: programmed cell death, which is regulated by various signaling pathways * Atp:adp antiporter activity: the regulation of ATP and ADP production and utilization * Disease: various diseases, including pancreatic disorders, are associated with alterations in gene expression and protein function * Hiv infection: HIV infection can lead to alterations in gene expression and protein function in pancreatic acinar cells * Host interactions of hiv factors: HIV infection can lead to interactions between HIV factors and host cellular proteins * Infectious disease: various infectious diseases, including pancreatic disorders, are associated with alterations in gene expression and protein function * Influenza infection: influenza infection can lead to alterations in gene expression and protein function in pancreatic acinar cells * Influenza virus induced apoptosis: influenza virus infection can lead to programmed cell death in pancreatic acinar cells * Interactions of vpr with host cellular proteins: Vpr, a protein from HIV, can interact with host cellular proteins and regulate gene expression and protein function * Membrane: various membrane-bound proteins are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Metabolism of proteins: various metabolic pathways are involved in the regulation of protein synthesis and degradation in pancreatic acinar cells * Mitochondrial adp transmembrane transport: the regulation of ADP transport across the mitochondrial membrane * Mitochondrial atp transmembrane transport: the regulation of ATP transport across the mitochondrial membrane * Mitochondrial inner membrane: the regulation of gene expression and protein function in the mitochondrial inner membrane * Mitochondrial protein degradation: the regulation of protein degradation in the mitochondrial matrix * Mitochondrial protein import: the regulation of protein import into the mitochondrial matrix * Mitochondrion: various mitochondrial proteins are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway: the regulation of mitochondrial outer membrane permeabilization and programmed cell death * Nucleus: various nuclear proteins are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Protein binding: various protein-binding interactions are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Protein localization: various protein-localization interactions are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Slc-mediated transmembrane transport: the regulation of transmembrane transport across the plasma membrane * Tim23 mitochondrial import inner membrane translocase complex: the regulation of mitochondrial protein import into the mitochondrial matrix * Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane: the regulation of nucleotide transport across the plasma membrane * Transport of small molecules: various small-molecule transporters are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Transport of vitamins, nucleosides, and related molecules: various vitamin and nucleotide transporters are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Viral infection pathways: various viral infection pathways are involved in the regulation of gene expression and protein function in pancreatic acinar cells * Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization: the regulation of programmed cell death by Vpr-induced mitochondrial outer membrane permeabilization These pathways play critical roles in the regulation of gene expression and protein function in pancreatic acinar cells, and alterations in these pathways can lead to various pancreatic disorders.