Details for: CL0002064

Cell ID: CL0002064

Cell Name: pancreatic acinar cell

Marker Score Threshold: 2,111
(Derived using integrated single-cell and genomic data)

Description: A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.

Synonyms: acinar cell of pancreas

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 10.2
    Ensembl ID: ENSG00000169100
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 6.06
    Ensembl ID: ENSG00000132475
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 5.59
    Ensembl ID: ENSG00000163041
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 5.56
    Ensembl ID: ENSG00000135390
  • Gene Symbol: GP2 (ENSG00000169347)
    Fold Change: 5.47
    Ensembl ID: ENSG00000169347
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 5.44
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 5.38
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 5.37
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 5.25
    Ensembl ID: ENSG00000166347
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 5.18
    Ensembl ID: ENSG00000099624
  • Gene Symbol: MIF (ENSG00000240972)
    Fold Change: 5.12
    Ensembl ID: ENSG00000240972
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 5.05
    Ensembl ID: ENSG00000143774
  • Gene Symbol: DDT (ENSG00000099977)
    Fold Change: 5.02
    Ensembl ID: ENSG00000099977
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 5.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 4.66
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 4.66
    Ensembl ID: ENSG00000154518
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 4.56
    Ensembl ID: ENSG00000165119
  • Gene Symbol: H1 2 (ENSG00000187837)
    Fold Change: 4.5
    Ensembl ID: ENSG00000187837
  • Gene Symbol: CD99 (ENSG00000002586)
    Fold Change: 4.27
    Ensembl ID: ENSG00000002586
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 4.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 4.12
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 4.09
    Ensembl ID: ENSG00000152234
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 4.05
    Ensembl ID: ENSG00000164032
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 4.05
    Ensembl ID: ENSG00000167468
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 4.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 3.87
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 3.85
    Ensembl ID: ENSG00000159199
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 3.84
    Ensembl ID: ENSG00000161960
  • Gene Symbol: IGBP1 (ENSG00000089289)
    Fold Change: 3.8
    Ensembl ID: ENSG00000089289
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 3.79
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 3.76
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 3.74
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 3.67
    Ensembl ID: ENSG00000100300
  • Gene Symbol: IDH2 (ENSG00000182054)
    Fold Change: 3.59
    Ensembl ID: ENSG00000182054
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 3.58
    Ensembl ID: ENSG00000160014
  • Gene Symbol: H1 0 (ENSG00000189060)
    Fold Change: 3.53
    Ensembl ID: ENSG00000189060
  • Gene Symbol: GNB2 (ENSG00000172354)
    Fold Change: 3.5
    Ensembl ID: ENSG00000172354
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 3.44
    Ensembl ID: ENSG00000051523
  • Gene Symbol: GSTA1 (ENSG00000243955)
    Fold Change: 3.41
    Ensembl ID: ENSG00000243955
  • Gene Symbol: DPEP1 (ENSG00000015413)
    Fold Change: 3.26
    Ensembl ID: ENSG00000015413
  • Gene Symbol: ETFB (ENSG00000105379)
    Fold Change: 3.2
    Ensembl ID: ENSG00000105379
  • Gene Symbol: CD68 (ENSG00000129226)
    Fold Change: 3.16
    Ensembl ID: ENSG00000129226
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 3.07
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 3.05
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.98
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 2.96
    Ensembl ID: ENSG00000175416
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.87
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.86
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.83
    Ensembl ID: ENSG00000130402
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 2.71
    Ensembl ID: ENSG00000215301
  • Gene Symbol: MAGOH (ENSG00000162385)
    Fold Change: 2.67
    Ensembl ID: ENSG00000162385
  • Gene Symbol: GAMT (ENSG00000130005)
    Fold Change: 2.57
    Ensembl ID: ENSG00000130005
  • Gene Symbol: CPA1 (ENSG00000091704)
    Fold Change: 2.57
    Ensembl ID: ENSG00000091704
  • Gene Symbol: CPA2 (ENSG00000158516)
    Fold Change: 2.57
    Ensembl ID: ENSG00000158516
  • Gene Symbol: CPB1 (ENSG00000153002)
    Fold Change: 2.57
    Ensembl ID: ENSG00000153002
  • Gene Symbol: CTRB1 (ENSG00000168925)
    Fold Change: 2.57
    Ensembl ID: ENSG00000168925
  • Gene Symbol: CLPS (ENSG00000137392)
    Fold Change: 2.57
    Ensembl ID: ENSG00000137392
  • Gene Symbol: CEL (ENSG00000170835)
    Fold Change: 2.57
    Ensembl ID: ENSG00000170835
  • Gene Symbol: CXCL8 (ENSG00000169429)
    Fold Change: 2.55
    Ensembl ID: ENSG00000169429
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.54
    Ensembl ID: ENSG00000156508
  • Gene Symbol: KLK1 (ENSG00000167748)
    Fold Change: 2.53
    Ensembl ID: ENSG00000167748
  • Gene Symbol: GATM (ENSG00000171766)
    Fold Change: 2.52
    Ensembl ID: ENSG00000171766
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 2.51
    Ensembl ID: ENSG00000123505
  • Gene Symbol: FDFT1 (ENSG00000079459)
    Fold Change: 2.51
    Ensembl ID: ENSG00000079459
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.5
    Ensembl ID: ENSG00000075624
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 2.5
    Ensembl ID: ENSG00000240038
  • Gene Symbol: AMY2A (ENSG00000243480)
    Fold Change: 2.48
    Ensembl ID: ENSG00000243480
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.47
    Ensembl ID: ENSG00000167658
  • Gene Symbol: KARS1 (ENSG00000065427)
    Fold Change: 2.47
    Ensembl ID: ENSG00000065427
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.46
    Ensembl ID: ENSG00000087086
  • Gene Symbol: CTRL (ENSG00000141086)
    Fold Change: 2.45
    Ensembl ID: ENSG00000141086
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.45
    Ensembl ID: ENSG00000184009
  • Gene Symbol: HMGA1 (ENSG00000137309)
    Fold Change: 2.44
    Ensembl ID: ENSG00000137309
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.43
    Ensembl ID: ENSG00000168028
  • Gene Symbol: HNRNPH3 (ENSG00000096746)
    Fold Change: 2.41
    Ensembl ID: ENSG00000096746
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.4
    Ensembl ID: ENSG00000111640
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 2.4
    Ensembl ID: ENSG00000166825
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.4
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.39
    Ensembl ID: ENSG00000163631
  • Gene Symbol: DNAJA1 (ENSG00000086061)
    Fold Change: 2.39
    Ensembl ID: ENSG00000086061
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.38
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GARS1 (ENSG00000106105)
    Fold Change: 2.37
    Ensembl ID: ENSG00000106105
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.36
    Ensembl ID: ENSG00000167996
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.36
    Ensembl ID: ENSG00000104529
  • Gene Symbol: IDH3G (ENSG00000067829)
    Fold Change: 2.36
    Ensembl ID: ENSG00000067829
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.34
    Ensembl ID: ENSG00000087460
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.34
    Ensembl ID: ENSG00000096384
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.34
    Ensembl ID: ENSG00000166710
  • Gene Symbol: HDLBP (ENSG00000115677)
    Fold Change: 2.33
    Ensembl ID: ENSG00000115677
  • Gene Symbol: HNRNPH2 (ENSG00000126945)
    Fold Change: 2.33
    Ensembl ID: ENSG00000126945
  • Gene Symbol: DGUOK (ENSG00000114956)
    Fold Change: 2.32
    Ensembl ID: ENSG00000114956
  • Gene Symbol: AQP8 (ENSG00000103375)
    Fold Change: 2.31
    Ensembl ID: ENSG00000103375
  • Gene Symbol: MDH1 (ENSG00000014641)
    Fold Change: 2.31
    Ensembl ID: ENSG00000014641
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.29
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.29
    Ensembl ID: ENSG00000101439
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.28
    Ensembl ID: ENSG00000122545
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.28
    Ensembl ID: ENSG00000109971
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 2.27
    Ensembl ID: ENSG00000063046
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.27
    Ensembl ID: ENSG00000135404
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.26
    Ensembl ID: ENSG00000263001

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pancreatic acinar cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pancreatic acinar cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Secretory cells of the pancreas * Produce digestive enzymes and mucins * Basal nucleus and basophilic cytoplasm * Regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules * Involved in apoptosis, DNA replication, and protein metabolism * Gene SLC25A6 is associated with these cells * Involved in various cellular processes, including: + Apoptotic process + Atp:adp antiporter activity + Disease + Host interactions of hiv factors + Infectious disease + Influenza infection + Influenza virus induced apoptosis + Interactions of vpr with host cellular proteins + Membrane + Metabolism of proteins + Mitochondrial adp transmembrane transport + Mitochondrial atp transmembrane transport + Mitochondrial inner membrane + Mitochondrial protein degradation + Mitochondrial protein import + Mitochondrion + Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + Nucleus + Protein binding + Protein localization + Slc-mediated transmembrane transport + Tim23 mitochondrial import inner membrane translocase complex + Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane + Transport of small molecules + Transport of vitamins, nucleosides, and related molecules + Viral infection pathways + Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization **Clinical Significance** Pancreatic acinar cells play a crucial role in maintaining pancreatic homeostasis and are involved in various cellular processes, including apoptosis, DNA replication, and protein metabolism. Dysregulation of these cells has been linked to various diseases, including: * Pancreatitis: inflammation of the pancreas * Pancreatic cancer: uncontrolled growth of abnormal cells in the pancreas * Diabetes mellitus: hormonal imbalance in the pancreas * Gastrointestinal disorders: digestive enzyme deficiencies * Respiratory disorders: mucin-related diseases Understanding the function and regulation of pancreatic acinar cells is essential for the development of novel therapeutic strategies for these diseases. Additionally, the study of these cells can provide insights into the molecular mechanisms underlying various cellular processes and the development of new treatments for cancer and other diseases.