Details for: CL0002067

Cell ID: CL0002067

Cell Name: type A enteroendocrine cell

Marker Score Threshold: 403
(Derived using integrated single-cell and genomic data)

Description: An enteroendocrine cell that produces glucagon.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.35
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.31
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.29
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.25
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.21
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.21
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.19
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.14
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.1
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.09
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.09
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.06
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.06
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.05
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 2.05
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.95
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.93
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.89
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.88
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.85
    Ensembl ID: ENSG00000071553
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.8
    Ensembl ID: ENSG00000130294
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.77
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.76
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.75
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.75
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.74
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.74
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.74
    Ensembl ID: ENSG00000176171
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 1.73
    Ensembl ID: ENSG00000091583
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.73
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.72
    Ensembl ID: ENSG00000004059
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.7
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.67
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.66
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.66
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.65
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.64
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.62
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.62
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGAP1 (ENSG00000175220)
    Fold Change: 1.57
    Ensembl ID: ENSG00000175220
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.55
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.54
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.54
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.54
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.53
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.51
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.5
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.5
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.46
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.44
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.43
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.4
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100852
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.38
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.36
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.35
    Ensembl ID: ENSG00000147416
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.34
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.34
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.33
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.31
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.31
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.29
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.26
    Ensembl ID: ENSG00000174437
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.25
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.23
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.23
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.23
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.22
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ARSA (ENSG00000100299)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100299
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.15
    Ensembl ID: ENSG00000204574
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.15
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.12
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.12
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.12
    Ensembl ID: ENSG00000156110
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.12
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.1
    Ensembl ID: ENSG00000074370
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100280
  • Gene Symbol: BCL9 (ENSG00000116128)
    Fold Change: 1.08
    Ensembl ID: ENSG00000116128
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.06
    Ensembl ID: ENSG00000121410
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.06
    Ensembl ID: ENSG00000106992
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.03
    Ensembl ID: ENSG00000114573
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: N/A
    Ensembl ID: ENSG00000110330
Hovered Details

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Hovered Details

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**Key Characteristics** The type A enteroendocrine cell is characterized by its ability to produce glucagon, a hormone that plays a crucial role in regulating blood sugar levels. The cell's gene symbol, ACTB, encodes for a protein that is involved in various cellular processes, including actin cytoskeleton and adherens junction formation. The cell's pathways and ontology are also characterized by their involvement in cellular processes such as cell-cell communication, cell-cell junction organization, and cytoskeleton organization. **Clinical Significance** The type A enteroendocrine cell's ability to produce glucagon has significant clinical implications. Glucagon deficiency or excess can lead to various metabolic disorders, including hypoglycemia and hyperglycemia. For example, glucagonoma, a rare tumor of the pancreas, can cause glucagon excess, leading to hyperglycemia and other symptoms. Similarly, glucagon deficiency can lead to hypoglycemia, which can cause symptoms such as shakiness, dizziness, and confusion. In addition to its clinical significance, the type A enteroendocrine cell's role in regulating blood sugar levels also has implications for the treatment of diabetes. Glucagon-like peptide-1 (GLP-1) analogs, which mimic the action of glucagon, are used to treat type 2 diabetes and improve glycemic control. Understanding the mechanisms of glucagon production and regulation can also lead to the development of new treatments for diabetes. Furthermore, the type A enteroendocrine cell's role in regulating blood sugar levels also has implications for our understanding of metabolic disorders. For example, research has shown that glucagon excess can contribute to the development of metabolic syndrome, a cluster of conditions that increase the risk of developing type 2 diabetes and cardiovascular disease. In conclusion, the type A enteroendocrine cell's ability to produce glucagon has significant clinical implications, both for the treatment of diabetes and for our understanding of metabolic disorders. Further research on the mechanisms of glucagon production and regulation is needed to fully understand its role in human health and disease.