Cell ID: CL0002075

Cell Name: brush cell of tracheobronchial tree

CSI Thresholds:

Select	Context	Threshold
	Overall	8.9996
	Lung parenchyma + Healthy	296.9992
	Lung parenchyma	288.9891
	Lung adenocarcinoma	40.8512
	Respiratory airway + Healthy	27.2792
	Respiratory airway	27.2551
	Lung + Cystic fibrosis	24.2105
	Cystic fibrosis	24.0101
	Nose + Healthy	19.6363
	Nose	8.2278
	Lung + COVID-19	7.5814
	COVID-19	7.5147
	Lung	7.1234
	Chronic rhinitis	5.7136
	Nose + Chronic rhinitis	5.6724
	Healthy	5.5549
	Lung + Lung adenocarcinoma	4.9783
	Lung + Interstitial lung disease	4.5895
	Interstitial lung disease	4.5671
	Lung + Healthy	3.3567

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense.

Synonyms: pulmonary brush cell