Details for: CL0002088

Cell ID: CL0002088

Cell Name: interstitial cell of Cajal

Marker Score Threshold: 346
(Derived using integrated single-cell and genomic data)

Description: This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.

Synonyms: ICC, intestinal pacemaker cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.5
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.19
    Ensembl ID: ENSG00000184009
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.18
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.14
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.06
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.91
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.89
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.82
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.58
    Ensembl ID: ENSG00000135404
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.57
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.5
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.48
    Ensembl ID: ENSG00000179218
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.45
    Ensembl ID: ENSG00000133639
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.42
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.41
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.38
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.35
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.34
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.32
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.28
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.28
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.23
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.19
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.19
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.1
    Ensembl ID: ENSG00000198668
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.09
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.05
    Ensembl ID: ENSG00000122786
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.02
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.94
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.92
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.89
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.85
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.83
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.8
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.76
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.72
    Ensembl ID: ENSG00000168374
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.67
    Ensembl ID: ENSG00000149257
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.65
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.64
    Ensembl ID: ENSG00000085224
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.62
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.62
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.61
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.58
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.57
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.57
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.56
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.54
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.53
    Ensembl ID: ENSG00000026508
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.51
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.49
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.48
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.46
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.44
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.44
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.43
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.4
    Ensembl ID: ENSG00000107796
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.38
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.37
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.36
    Ensembl ID: ENSG00000128595
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.36
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.34
    Ensembl ID: ENSG00000104763
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.34
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.34
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.32
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.32
    Ensembl ID: ENSG00000072110
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.31
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.27
    Ensembl ID: ENSG00000185883
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.27
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.21
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.2
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.2
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.16
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.15
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.15
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.14
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BCHE (ENSG00000114200)
    Fold Change: 1.13
    Ensembl ID: ENSG00000114200
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.11
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.11
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127837
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.08
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.07
    Ensembl ID: ENSG00000116489
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.06
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.03
    Ensembl ID: ENSG00000120805
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.03
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.03
    Ensembl ID: ENSG00000071553
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.01
    Ensembl ID: ENSG00000113328
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: N/A
    Ensembl ID: ENSG00000143799
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: N/A
    Ensembl ID: ENSG00000138760
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: ICCs are found in the gastrointestinal tract of mammals, particularly in the interstitial tissue between smooth muscle cells. 2. **Function**: ICCs act as pacemakers, generating electrical impulses that stimulate smooth muscle contraction and relaxation, thereby regulating gut peristalsis. 3. **Cell Signaling**: ICCs communicate with the enteric nervous system and smooth muscle cells through various signaling pathways, including the Wnt/β-catenin pathway. 4. **Cytoskeleton Organization**: ICCs have a unique cytoskeleton organization, which allows them to generate electrical impulses and transmit signals to smooth muscle cells. 5. **Gastrointestinal Stromal Tumors (GISTs)**: ICCs are thought to be the origin of GISTs, a type of cancer that affects the digestive system. **Clinical Significance** 1. **Gastrointestinal Motility Disorders**: ICC dysfunction can lead to gastrointestinal motility disorders, such as constipation, diarrhea, and abdominal pain. 2. **Gastrointestinal Stromal Tumors (GISTs)**: ICCs are thought to be the origin of GISTs, which can lead to gastrointestinal bleeding, obstruction, and perforation. 3. **Neurological Disorders**: ICCs have been implicated in various neurological disorders, including Parkinson's disease, multiple sclerosis, and epilepsy. 4. **Cancer Research**: ICCs have been studied as a model for cancer research, particularly in the context of GISTs and other gastrointestinal cancers. 5. **Therapeutic Applications**: Understanding ICC function and dysfunction has implications for the development of novel therapeutic strategies for gastrointestinal disorders and cancers. **Pathways and Ontology** 1. **Actin Filament**: ICCs have a unique actin filament organization, which allows them to generate electrical impulses and transmit signals to smooth muscle cells. 2. **Adherens Junctions**: ICCs form adherens junctions with smooth muscle cells and the enteric nervous system, facilitating communication and signaling. 3. **Apical Junction Complex**: ICCs have a complex of apical junction proteins, which regulates cell-cell adhesion and signaling. 4. **Blood Microparticle**: ICCs release blood microparticles, which can influence cellular signaling and inflammation. 5. **Rho GTPase Cycle**: ICCs have a Rho GTPase cycle, which regulates cytoskeleton organization and cell signaling. In conclusion, the interstitial cell of Cajal is a unique cell type that plays a crucial role in regulating gut contraction and peristalsis. Understanding ICC function and dysfunction has significant implications for the development of novel therapeutic strategies for gastrointestinal disorders and cancers.