Cell ID: CL0002088

Cell Name: interstitial cell of Cajal

CSI Thresholds:

Select	Context	Threshold
	Overall	9.4114
	Stomach + Healthy	87.5346
	Stomach	87.0838
	Intestine	74.6861
	Colon + Healthy	29.5388
	Intestine + Healthy	29.3392
	Liver + Healthy	25.1162
	Colon	24.4917
	Duodeno-jejunal junction	18.7335
	Duodeno-jejunal junction + Healthy	18.6858
	Kidney	17.7376
	Ileum	14.3276
	Spleen + Healthy	13.3880
	Spleen	13.3032
	Large intestine	10.7189
	Small intestine	9.5046
	Liver	9.0293
	Healthy	7.9172
	Esophagus muscularis mucosa + Healthy	7.4230
	Esophagus muscularis mucosa	7.4164
	Lung	5.8271
	Small intestine + Healthy	5.6753
	Lung + Healthy	4.2103
	Large intestine + Healthy	3.0520
	Thymus	2.9562
	Thymus + Healthy	2.8989
	Alveolar sac + Healthy	0.6931
	Alveolar sac	0.6864
	Kidney + Healthy	-6.6886
	Ileum + Healthy	-11.3379

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.

Synonyms: ICC, intestinal pacemaker cell