Details for: CL0002097

Cell ID: CL0002097

Cell Name: cortical cell of adrenal gland

Marker Score Threshold: 17752
(Derived using integrated single-cell and genomic data)

Description: A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol.

Synonyms: adrenal cortex cell, adrenocortical cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SCARB1 (ENSG00000073060)
    Fold Change: 13.13
    Ensembl ID: ENSG00000073060
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 9.96
    Ensembl ID: ENSG00000130203
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 9.63
    Ensembl ID: ENSG00000165995
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 6.09
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 5.86
    Ensembl ID: ENSG00000142192
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 5.27
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 5.04
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 4.94
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 4.85
    Ensembl ID: ENSG00000072210
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 4.7
    Ensembl ID: ENSG00000130208
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 4.12
    Ensembl ID: ENSG00000157388
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 4.09
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.68
    Ensembl ID: ENSG00000198363
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 3.57
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 3.54
    Ensembl ID: ENSG00000097007
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 3.39
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 3.18
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 3.16
    Ensembl ID: ENSG00000023330
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.15
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 3.07
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.91
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.89
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.86
    Ensembl ID: ENSG00000165029
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 2.82
    Ensembl ID: ENSG00000112936
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.81
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.71
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.66
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.64
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 2.62
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 2.56
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.39
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.38
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 2.38
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.36
    Ensembl ID: ENSG00000069849
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.36
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.32
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.31
    Ensembl ID: ENSG00000133639
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.29
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.24
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.21
    Ensembl ID: ENSG00000118137
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.2
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.16
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.12
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.09
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.08
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BCHE (ENSG00000114200)
    Fold Change: 2.06
    Ensembl ID: ENSG00000114200
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.05
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.97
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.94
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.88
    Ensembl ID: ENSG00000107779
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.84
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.74
    Ensembl ID: ENSG00000114573
  • Gene Symbol: CASP9 (ENSG00000132906)
    Fold Change: 1.73
    Ensembl ID: ENSG00000132906
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.73
    Ensembl ID: ENSG00000160014
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.72
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.62
    Ensembl ID: ENSG00000100852
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.62
    Ensembl ID: ENSG00000128595
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.61
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BBS2 (ENSG00000125124)
    Fold Change: 1.58
    Ensembl ID: ENSG00000125124
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.58
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.56
    Ensembl ID: ENSG00000138356
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.5
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.5
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.5
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.49
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.48
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.43
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.43
    Ensembl ID: ENSG00000168374
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.42
    Ensembl ID: ENSG00000101966
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.42
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.41
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.39
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.37
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.37
    Ensembl ID: ENSG00000151746
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.34
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.34
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.33
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.32
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.32
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.32
    Ensembl ID: ENSG00000120437
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.31
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.3
    Ensembl ID: ENSG00000082258
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.23
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.21
    Ensembl ID: ENSG00000166747
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.2
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.19
    Ensembl ID: ENSG00000183044
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.18
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.16
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143727
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.05
    Ensembl ID: ENSG00000001631
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143149
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.03
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.01
    Ensembl ID: ENSG00000141522
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Cortical cell of the adrenal gland (also known as adrenal cortex cell or adrenocortical cell). 2. **Function**: Synthesizes and secretes chemical derivatives (steroids) of cholesterol. 3. **Location**: Adrenal cortex, one of the two layers of the adrenal gland. 4. **Gene Symbol**: SCARB1 (Scavenger Receptor Class B, Member 1). 5. **Ensembl ID**: ENSG00000073060. 6. **Pathways/Ontology**: Involved in various biological processes, including cholesterol homeostasis, lipid metabolism, and transport of lipids across cell membranes. **Clinical Significance** 1. **Dysregulation of Cholesterol Homeostasis**: Imbalances in cholesterol homeostasis can lead to various diseases, including atherosclerosis, hypertension, and cardiovascular disease. 2. **Lipid Metabolic Disorders**: Abnormalities in lipid metabolism can result in conditions such as hyperlipidemia, dyslipidemia, and lipid-related disorders. 3. **Cancer**: Aberrant expression of scavenger receptors has been implicated in various cancers, including breast, lung, and colon cancer. 4. **Metabolic Syndrome**: Cortical cells of the adrenal gland play a role in regulating glucose and lipid metabolism, and dysregulation of these processes can contribute to the development of metabolic syndrome. 5. **Neurological Disorders**: The transport of lipids across cell membranes, facilitated by scavenger receptors, is involved in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, the cortical cell of the adrenal gland is a critical component of the body's lipid metabolism and cholesterol homeostasis. Dysregulation of these processes can lead to various diseases and disorders, highlighting the importance of understanding the function and regulation of these cells.