Details for: CL0002117

Cell ID: CL0002117

Cell Name: IgG-negative class switched memory B cell

Marker Score Threshold: 985
(Derived using integrated single-cell and genomic data)

Description: A class switched memory B cell that lacks IgG on the cell surface.

Synonyms: IgG- class switched memory B cell, IgG- class switched memory B lymphocyte, IgG- class switched memory B-cell, IgG- class switched memory B-lymphocyte, IgG-negative class switched memory B lymphocyte, IgG-negative class switched memory B-cell, IgG-negative class switched memory B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 4.3
    Ensembl ID: ENSG00000105369
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 4.26
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 4.11
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 4.01
    Ensembl ID: ENSG00000133639
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.01
    Ensembl ID: ENSG00000166710
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 3.93
    Ensembl ID: ENSG00000156738
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.91
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.74
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 3.68
    Ensembl ID: ENSG00000007312
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.67
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 3.63
    Ensembl ID: ENSG00000117091
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 3.59
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.52
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.49
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.42
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.22
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 3
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 2.87
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.84
    Ensembl ID: ENSG00000110651
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.75
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.67
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.63
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.58
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.57
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD22 (ENSG00000012124)
    Fold Change: 2.52
    Ensembl ID: ENSG00000012124
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.5
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CD40 (ENSG00000101017)
    Fold Change: 2.43
    Ensembl ID: ENSG00000101017
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.42
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.4
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.39
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 2.32
    Ensembl ID: ENSG00000184922
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.3
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.29
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.19
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.05
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 2.04
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 2.02
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.97
    Ensembl ID: ENSG00000136573
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.96
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.94
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.89
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.89
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.87
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.84
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.81
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.79
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.76
    Ensembl ID: ENSG00000110987
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.74
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.7
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.7
    Ensembl ID: ENSG00000156273
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.7
    Ensembl ID: ENSG00000173020
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.69
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.69
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.69
    Ensembl ID: ENSG00000087088
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.68
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.67
    Ensembl ID: ENSG00000157764
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.64
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.61
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.6
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.6
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.56
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.56
    Ensembl ID: ENSG00000196954
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.55
    Ensembl ID: ENSG00000140299
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.5
    Ensembl ID: ENSG00000100300
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.5
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.47
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100823
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.41
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.41
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.37
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.37
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.36
    Ensembl ID: ENSG00000074370
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.35
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.32
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.32
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.31
    Ensembl ID: ENSG00000089820
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.3
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.27
    Ensembl ID: ENSG00000177455
  • Gene Symbol: CD72 (ENSG00000137101)
    Fold Change: 1.26
    Ensembl ID: ENSG00000137101
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.23
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.22
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.19
    Ensembl ID: ENSG00000159461
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.17
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.11
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.11
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.06
    Ensembl ID: ENSG00000126247
Hovered Details

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Hovered Details

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**Key Characteristics** The IgG-negative class-switched memory B cell is a subset of B cells that has undergone class switching to produce IgM or IgA antibodies. However, unlike IgM or IgA B cells, these cells do not express surface-bound IgG. Instead, they express CD37, a protein that plays a crucial role in regulating B cell activation and differentiation. The IgG-negative class-switched memory B cell is characterized by its: * Lack of surface-bound IgG * Expression of CD37 * Gene expression profile that is distinct from other B cell subsets * Ability to produce IgM or IgA antibodies * Role in the adaptive immune response, particularly in antibody-mediated immunity **Clinical Significance** The IgG-negative class-switched memory B cell plays a crucial role in the adaptive immune response, particularly in the context of antibody-mediated immunity. This cell type is involved in the defense against infections, including viral and bacterial infections. Clinical significance of IgG-negative class-switched memory B cells includes: * Their role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus * Their involvement in the pathogenesis of infections, such as HIV and tuberculosis * Their potential as a target for therapeutic interventions, such as immunotherapy and vaccine development **Potential Therapeutic Applications** The IgG-negative class-switched memory B cell has potential therapeutic applications in the treatment of various diseases, including: * Immunotherapy: Targeting the IgG-negative class-switched memory B cell could lead to the development of novel immunotherapies for the treatment of autoimmune diseases and cancers. * Vaccine development: Understanding the role of the IgG-negative class-switched memory B cell in vaccine-induced immunity could lead to the development of more effective vaccines. * Infectious disease treatment: Targeting the IgG-negative class-switched memory B cell could lead to the development of novel treatments for infectious diseases, such as HIV and tuberculosis. In conclusion, the IgG-negative class-switched memory B cell is a unique and important subset of B cells that plays a crucial role in the adaptive immune response. Further research on this cell type is needed to fully understand its role in human health and disease, and to develop novel therapeutic interventions.