Details for: CL0002139

Cell ID: CL0002139

Cell Name: endothelial cell of vascular tree

Marker Score Threshold: 1453
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.

Synonyms: vascular endothelial cell, cubodial endothelial cell of vascular tree

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.5
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.23
    Ensembl ID: ENSG00000169100
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.86
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 3.79
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.69
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 3.37
    Ensembl ID: ENSG00000105974
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3.23
    Ensembl ID: ENSG00000175899
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.02
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.86
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.75
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.7
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.65
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.51
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.51
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.46
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.41
    Ensembl ID: ENSG00000163399
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.28
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 2.26
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.26
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.26
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 2.17
    Ensembl ID: ENSG00000105971
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.17
    Ensembl ID: ENSG00000153113
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 2.12
    Ensembl ID: ENSG00000183255
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.11
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.07
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.05
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.02
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.93
    Ensembl ID: ENSG00000114423
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.9
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.89
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.87
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.86
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152518
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.85
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.84
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.83
    Ensembl ID: ENSG00000084234
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.83
    Ensembl ID: ENSG00000119138
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.82
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.82
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.78
    Ensembl ID: ENSG00000139567
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.77
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.74
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.69
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.69
    Ensembl ID: ENSG00000186716
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.68
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.67
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.64
    Ensembl ID: ENSG00000106546
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.63
    Ensembl ID: ENSG00000130303
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.62
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.6
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.59
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.58
    Ensembl ID: ENSG00000145349
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.58
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.49
    Ensembl ID: ENSG00000137486
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.48
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.46
    Ensembl ID: ENSG00000162772
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.45
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.35
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.34
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.31
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.3
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.3
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.3
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.25
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.23
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.23
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.21
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165527
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.2
    Ensembl ID: ENSG00000079102
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.2
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.18
    Ensembl ID: ENSG00000174437
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.18
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.15
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.12
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.11
    Ensembl ID: ENSG00000156273
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.1
    Ensembl ID: ENSG00000183020
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.1
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.1
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.09
    Ensembl ID: ENSG00000067955
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.07
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.03
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.02
    Ensembl ID: ENSG00000130208
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110330
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.02
    Ensembl ID: ENSG00000128595
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.01
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular Location**: Endothelial cells of the vascular tree, including blood vessels and lymphatic vessels. 2. **Gene Expression**: B2M, SLC25A6, and APP, which are involved in antigen presentation, protein metabolism, and amyloid fiber formation. 3. **Pathways and Ontologies**: Adaptive immune system, Amyloid fiber formation, Antigen presentation: folding, assembly and peptide loading of class I MHC, Antigen processing-cross presentation, Antigen processing and presentation of endogenous peptide antigen via MHC class I, Antigen processing and presentation of exogenous peptide antigen via MHC class II, Antigen processing and presentation of exogenous protein antigen via MHC class IB, Tap-dependent, Bacterial infection pathways, Cellular response to iron(III) ion, Cellular response to iron ion, Cellular response to nicotine, Class I MHC-mediated antigen processing & presentation, Cytokine signaling in immune system, Cytosol, Dap12 interactions, Dap12 signaling, Disease, Early endosome lumen, Early endosome membrane, Endoplasmic reticulum, Endoplasmic reticulum lumen, Endosomal/vacuolar pathway, Er-phagosome pathway, Er to Golgi transport vesicle membrane, External side of plasma membrane, Extracellular exosome, Extracellular region, Extracellular space, Focal adhesion, Golgi apparatus, Golgi membrane, Hfe-transferrin receptor complex, Hiv infection, Host interactions of hiv factors, Identical protein binding, Immune system, Immunoregulatory interactions between a lymphoid and a non-lymphoid cell, Infection with mycobacterium tuberculosis, Infectious disease, Innate immune system, Interferon gamma signaling, Interferon signaling, Intracellular iron ion homeostasis, Iron ion transport, Late endosome membrane, Learning or memory, Lysosomal membrane, Membrane, Metabolism of proteins, MHC class II protein complex, MHC class II protein complex binding, MHC class I peptide loading complex, MHC class I protein complex, Modulation by mtb of host immune system, Multicellular organismal-level iron ion homeostasis, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Nef mediated downregulation of MHC class I complex cell surface expression, Negative regulation of epithelial cell proliferation, Negative regulation of forebrain neuron differentiation, Negative regulation of neurogenesis, Negative regulation of neuron projection development, Negative regulation of receptor binding, Neutrophil degranulation, Peptide antigen assembly with MHC class II protein complex, Peptide antigen assembly with MHC class I protein complex, Peptide antigen binding, Phagocytic vesicle membrane, Plasma membrane, Positive regulation of cellular senescence, Positive regulation of ferrous iron binding, Positive regulation of immune response, Positive regulation of protein binding, Positive regulation of receptor-mediated endocytosis, Positive regulation of receptor binding, Positive regulation of T cell activation, Positive regulation of T cell cytokine production, Positive regulation of T cell-mediated cytotoxicity, Positive regulation of transferrin receptor binding, Protein binding, Protein homodimerization activity, Protein homotetramerization, Protein refolding, Recycling endosome membrane, Regulation of erythrocyte differentiation, Regulation of iron ion transport, Response to molecule of bacterial origin, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2 infection, SARS-CoV-2-host interactions, SARS-CoV infections, Sensory perception of smell, Specific granule lumen, Structural molecule activity, T cell differentiation in thymus, T cell-mediated cytotoxicity, Tertiary granule lumen, The role of Nef in HIV-1 replication and disease pathogenesis, Viral infection pathways. **Clinical Significance** Endothelial cells of the vascular tree play a crucial role in maintaining vascular homeostasis, regulating blood pressure, and facilitating the exchange of nutrients and waste products between the bloodstream and tissues. Abnormalities in endothelial function have been implicated in various diseases, including atherosclerosis, hypertension, and diabetes. The cell's pathways and ontologies highlight its involvement in adaptive and innate immune responses, amyloid fiber formation, and other cellular processes. This suggests that endothelial cells may play a role in the pathogenesis of diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Furthermore, the cell's expression of specific genes, including B2M, SLC25A6, and APP, highlights its involvement in protein metabolism and amyloid fiber formation. This suggests that endothelial cells may play a role in the pathogenesis of diseases such as Alzheimer's disease, where amyloid fibers are a hallmark of the disease. Overall, the endothelial cell of the vascular tree is a complex cell type that plays a crucial role in maintaining vascular homeostasis and regulating immune responses. Its abnormalities have been implicated in various diseases, and further research is needed to fully understand its role in disease pathogenesis.