Details for: CL0002151

Cell ID: CL0002151

Cell Name: late promyelocyte

Marker Score Threshold: 251
(Derived using integrated single-cell and genomic data)

Description: A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.46
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.41
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.2
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.19
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.11
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.91
    Ensembl ID: ENSG00000070831
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.75
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.74
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.56
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.54
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD33 (ENSG00000105383)
    Fold Change: 2.46
    Ensembl ID: ENSG00000105383
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.36
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.36
    Ensembl ID: ENSG00000026508
  • Gene Symbol: AZU1 (ENSG00000172232)
    Fold Change: 2.3
    Ensembl ID: ENSG00000172232
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.28
    Ensembl ID: ENSG00000110651
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.91
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.89
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.88
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.87
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.83
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.83
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.81
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.66
    Ensembl ID: ENSG00000166825
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.61
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.55
    Ensembl ID: ENSG00000010278
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.48
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.47
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.44
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.44
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.43
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.42
    Ensembl ID: ENSG00000110848
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.42
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.42
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.4
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.39
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.39
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.39
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CASP3 (ENSG00000164305)
    Fold Change: 1.36
    Ensembl ID: ENSG00000164305
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.34
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.33
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.33
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.32
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.32
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.31
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.3
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.3
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.29
    Ensembl ID: ENSG00000116489
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149131
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.27
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.27
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.23
    Ensembl ID: ENSG00000121691
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.23
    Ensembl ID: ENSG00000153113
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.23
    Ensembl ID: ENSG00000100823
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.22
    Ensembl ID: ENSG00000173020
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.22
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.21
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.2
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.18
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.18
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.14
    Ensembl ID: ENSG00000141480
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.13
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD4 (ENSG00000010610)
    Fold Change: 1.12
    Ensembl ID: ENSG00000010610
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.11
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.1
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.1
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.09
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.09
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.08
    Ensembl ID: ENSG00000069849
  • Gene Symbol: MS4A3 (ENSG00000149516)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149516
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.07
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163399
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.06
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.06
    Ensembl ID: ENSG00000085063
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.05
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.05
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.05
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134287
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.03
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.02
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.01
    Ensembl ID: ENSG00000071553
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * **Cell Type:** Late promyelocyte * **Stage of Development:** Myeloid cell development * **Chromatin Condensation:** More condensed chromatin * **Nucleoli:** No longer conspicuous * **Genes:** B2M * **Pathways/Ontologies:** + Adaptive immune system + Amyloid fiber formation + Amyloid fibril formation + Antigen presentation: folding, assembly and peptide loading of class I MHC + Antigen processing-cross presentation + Antigen processing and presentation of endogenous peptide antigen via MHC class I + Antigen processing and presentation of exogenous peptide antigen via MHC class II + Antigen processing and presentation of exogenous protein antigen via MHC class IB + Bacterial infection pathways + Cellular response to iron(III) ion + Cellular response to iron ion + Cellular response to nicotine + Class I MHC mediated antigen processing & presentation + Cytokine signaling in immune system + Cytosol + DAP12 interactions + DAP12 signaling + Disease + Early endosome lumen + Early endosome membrane + Endoplasmic reticulum + Endoplasmic reticulum lumen + Endosomal/vacuolar pathway + Er-phagosome pathway + Er to Golgi transport vesicle membrane + External side of plasma membrane + Extracellular exosome + Extracellular region + Extracellular space + Focal adhesion + Golgi apparatus + Golgi membrane + Hfe-transferrin receptor complex + HIV infection + Host interactions of HIV factors + Identical protein binding + Immune system + Immunoregulatory interactions between a lymphoid and a non-lymphoid cell + Infection with Mycobacterium tuberculosis + Infectious disease + Innate immune system + Interferon gamma signaling + Interferon signaling + Intracellular iron ion homeostasis + Iron ion transport + Late endosome membrane + Learning or memory + Lysosomal membrane + Membrane + Metabolism of proteins + MHC class II protein complex + MHC class II protein complex binding + MHC class I peptide loading complex + MHC class I protein complex + Modulation by MTB of host immune system + Multicellular organismal-level iron ion homeostasis + Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters + Nef mediated downregulation of MHC class I complex cell surface expression + Negative regulation of epithelial cell proliferation + Negative regulation of forebrain neuron differentiation + Negative regulation of neurogenesis + Negative regulation of neuron projection development + Negative regulation of receptor binding + Neutrophil degranulation + Peptide antigen assembly with MHC class II protein complex + Peptide antigen assembly with MHC class I protein complex + Peptide antigen binding + Phagocytic vesicle membrane + Plasma membrane + Positive regulation of cellular senescence + Positive regulation of ferrous iron binding + Positive regulation of immune response + Positive regulation of protein binding + Positive regulation of receptor-mediated endocytosis + Positive regulation of receptor binding + Positive regulation of T cell activation + Positive regulation of T cell cytokine production + Positive regulation of T cell mediated cytotoxicity + Positive regulation of transferrin receptor binding + Protein binding + Protein homodimerization activity + Protein homotetramerization + Protein refolding + Recycling endosome membrane + Regulation of erythrocyte differentiation + Regulation of iron ion transport + Response to molecule of bacterial origin + SARS-CoV-2 activates/modulates innate and adaptive immune responses + SARS-CoV-2 infection + SARS-CoV-2-host interactions + SARS-CoV infections + Sensory perception of smell + Specific granule lumen + Structural molecule activity + T cell differentiation in thymus + T cell mediated cytotoxicity + Tertiary granule lumen + The role of Nef in HIV-1 replication and disease pathogenesis + Viral infection pathways **Clinical Significance** The late promyelocyte is a stage in the development of myeloid cells, which are essential for the immune response. Abnormalities in this stage can lead to various diseases, including leukemia and lymphoma. The cell's genes, including B2M, are involved in antigen presentation and immune response, making them potential targets for therapeutic interventions. The cell's pathways and ontologies also involve various proteins and receptors, which can be targeted for therapeutic interventions. In the context of infectious diseases, the late promyelocyte's involvement in antigen processing and presentation can be exploited for vaccine development. Additionally, the cell's response to iron ions and its role in iron ion homeostasis can be targeted for therapeutic interventions in diseases related to iron overload. In the context of cancer, the late promyelocyte's involvement in antigen presentation and immune response can be exploited for immunotherapy. Additionally, the cell's response to iron ions and its role in iron ion homeostasis can be targeted for therapeutic interventions in diseases related to iron overload. Overall, the late promyelocyte is a complex cell with various functions and pathways, making it an important target for therapeutic interventions in various diseases.