Details for: CL0002187

Cell ID: CL0002187

Cell Name: basal cell of epidermis

Marker Score Threshold: 436
(Derived using integrated single-cell and genomic data)

Description: A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 31.07
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 15.25
    Ensembl ID: ENSG00000164733
  • Gene Symbol: CTSV (ENSG00000136943)
    Fold Change: 7.73
    Ensembl ID: ENSG00000136943
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 5
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CTSZ (ENSG00000101160)
    Fold Change: 4.72
    Ensembl ID: ENSG00000101160
  • Gene Symbol: CTSS (ENSG00000163131)
    Fold Change: 4.26
    Ensembl ID: ENSG00000163131
  • Gene Symbol: CTSL (ENSG00000135047)
    Fold Change: 4.06
    Ensembl ID: ENSG00000135047
  • Gene Symbol: CTSO (ENSG00000256043)
    Fold Change: 3.63
    Ensembl ID: ENSG00000256043
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.99
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.92
    Ensembl ID: ENSG00000140945
  • Gene Symbol: CTSK (ENSG00000143387)
    Fold Change: 2.91
    Ensembl ID: ENSG00000143387
  • Gene Symbol: COL17A1 (ENSG00000065618)
    Fold Change: 2.83
    Ensembl ID: ENSG00000065618
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 2.8
    Ensembl ID: ENSG00000091138
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.57
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.32
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.3
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.16
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.12
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.1
    Ensembl ID: ENSG00000127184
  • Gene Symbol: COL7A1 (ENSG00000114270)
    Fold Change: 2.07
    Ensembl ID: ENSG00000114270
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 2.06
    Ensembl ID: ENSG00000157514
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.9
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.87
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.85
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: DOCK1 (ENSG00000150760)
    Fold Change: 1.83
    Ensembl ID: ENSG00000150760
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.83
    Ensembl ID: ENSG00000026508
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.81
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CTSH (ENSG00000103811)
    Fold Change: 1.79
    Ensembl ID: ENSG00000103811
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.79
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165995
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.71
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.7
    Ensembl ID: ENSG00000113916
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.67
    Ensembl ID: ENSG00000198589
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.66
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.66
    Ensembl ID: ENSG00000135404
  • Gene Symbol: DPP4 (ENSG00000197635)
    Fold Change: 1.64
    Ensembl ID: ENSG00000197635
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.62
    Ensembl ID: ENSG00000135390
  • Gene Symbol: DSC3 (ENSG00000134762)
    Fold Change: 1.62
    Ensembl ID: ENSG00000134762
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 1.6
    Ensembl ID: ENSG00000074410
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.55
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.55
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.54
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.53
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.49
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.46
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.44
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.43
    Ensembl ID: ENSG00000051523
  • Gene Symbol: COL4A5 (ENSG00000188153)
    Fold Change: 1.42
    Ensembl ID: ENSG00000188153
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.41
    Ensembl ID: ENSG00000005022
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143669
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.4
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.39
    Ensembl ID: ENSG00000113712
  • Gene Symbol: DSG3 (ENSG00000134757)
    Fold Change: 1.37
    Ensembl ID: ENSG00000134757
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.37
    Ensembl ID: ENSG00000143761
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.36
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.35
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.35
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.35
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.33
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.33
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.33
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.33
    Ensembl ID: ENSG00000099622
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.33
    Ensembl ID: ENSG00000155368
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.33
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.31
    Ensembl ID: ENSG00000019582
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.29
    Ensembl ID: ENSG00000131174
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.28
    Ensembl ID: ENSG00000129562
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.27
    Ensembl ID: ENSG00000102554
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.26
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 1.21
    Ensembl ID: ENSG00000150672
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.18
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122545
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198931
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 1.16
    Ensembl ID: ENSG00000075711
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070831
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.14
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.13
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.13
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.12
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.12
    Ensembl ID: ENSG00000153113
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.11
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.06
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 1.05
    Ensembl ID: ENSG00000257923
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.05
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.04
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.04
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.03
    Ensembl ID: ENSG00000141522
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.03
    Ensembl ID: ENSG00000215301
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.02
    Ensembl ID: ENSG00000042753
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.02
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.01
    Ensembl ID: ENSG00000168374
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.01
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1
    Ensembl ID: ENSG00000149925
Hovered Details

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Hovered Details

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**Key Characteristics** * Basal cell of the epidermis, a type of keratinocyte * Columnar shape and attachment to the basement membrane * Gene symbol CTSD encodes cathepsin D, a lysosomal cysteine protease * Involved in various cellular processes such as protein degradation, antigen processing, and cell signaling * Plays a role in the adaptive immune system, antigen processing, and presentation of exogenous peptide antigens via MHC class II molecules * Expresses various proteases and peptidases, including cathepsin B, C, S, and Z * Participates in processes such as collagen degradation, collagen formation, and proteolysis involved in protein catabolic process **Clinical Significance** The basal cell of the epidermis plays a crucial role in maintaining the integrity of the skin barrier and regulating immune responses. Dysregulation of cathepsin D and other proteases involved in this cell can lead to various skin disorders, including: * Acne and other inflammatory skin conditions * Psoriasis and other autoimmune skin diseases * Skin cancer, such as basal cell carcinoma * Wound healing and tissue repair Understanding the function and regulation of cathepsin D and other proteases in this cell can provide insights into the molecular mechanisms underlying skin diseases and the development of novel therapeutic strategies. **Pathways and Ontologies** The cell is involved in various pathways and ontologies, including: * Adaptive immune system * Antigen processing and presentation of exogenous peptide antigens via MHC class II * Aspartic-type endopeptidase activity * Aspartic-type peptidase activity * Autophagosome assembly * Collagen-containing extracellular matrix * Collagen degradation * Cysteine-type endopeptidase activity * Degradation of the extracellular matrix * Endosome lumen * Endosome membrane * Esr-mediated signaling * Estrogen-dependent gene expression * Extracellular exosome * Extracellular matrix organization * Extracellular region * Extracellular space * Ficolin-1-rich granule lumen * Immune system * Innate immune system * Insulin catabolic process * Insulin receptor recycling * Lipoprotein catabolic process * Lysosomal lumen * Lysosomal membrane * Lysosome * Melanosome * Membrane raft * Metabolism of angiotensinogen to angiotensins * Metabolism of proteins * MHC class II antigen presentation * Neutrophil degranulation * Peptidase activity * Peptide hormone metabolism * Positive regulation of apoptotic process * Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process * Protein binding * Proteolysis * Regulation of establishment of protein localization * Signaling by insulin receptor * Signaling by nuclear receptors * Signaling by receptor tyrosine kinases * Signal transduction * Specific granule lumen * Tertiary granule lumen These pathways and ontologies highlight the complex interplay of cellular processes involved in the function of the basal cell of the epidermis.