Details for: CL0002201

Cell ID: CL0002201

Cell Name: renal beta-intercalated cell

Marker Score Threshold: 317
(Derived using integrated single-cell and genomic data)

Description: A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance.

Synonyms: type B intercalated cell, type B-IC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.18
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.13
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.82
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.78
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.68
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.65
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.44
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.19
    Ensembl ID: ENSG00000135404
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.09
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.09
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.06
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.99
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.94
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 1.93
    Ensembl ID: ENSG00000074410
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.92
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.89
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.88
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.81
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.79
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.76
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.67
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 1.65
    Ensembl ID: ENSG00000178538
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.64
    Ensembl ID: ENSG00000135218
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.63
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.61
    Ensembl ID: ENSG00000151150
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.6
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.56
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.56
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.54
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.52
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.52
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.52
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.52
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.48
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.47
    Ensembl ID: ENSG00000125864
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.44
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.44
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.42
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.41
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.41
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.41
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.38
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.34
    Ensembl ID: ENSG00000117410
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.34
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.33
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.32
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.3
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.3
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.3
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198898
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.28
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.27
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.26
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.23
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104894
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.18
    Ensembl ID: ENSG00000047648
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.16
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.15
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.15
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198691
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.13
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.13
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.12
    Ensembl ID: ENSG00000214274
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.11
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.1
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126247
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.08
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.07
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.07
    Ensembl ID: ENSG00000204217
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120907
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP4B (ENSG00000186009)
    Fold Change: 1.04
    Ensembl ID: ENSG00000186009
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 1.04
    Ensembl ID: ENSG00000039537
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.03
    Ensembl ID: ENSG00000155897
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177105
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The renal beta-intercalated cell is characterized by its unique morphology and function. Some of its key characteristics include: * **Location**: The renal beta-intercalated cell is found in the distal segments of the kidney tubule. * **Function**: The primary function of the renal beta-intercalated cell is to maintain acid-base balance by secreting base and reabsorbing acid. * **Ion transport**: The renal beta-intercalated cell is involved in the transport of ions, including hydrogen ions, bicarbonate ions, and chloride ions. * **pH regulation**: The renal beta-intercalated cell plays a crucial role in regulating the pH of the blood by controlling the amount of acid and base secreted or reabsorbed. * **Cellular signaling**: The renal beta-intercalated cell is involved in cellular signaling pathways, including those involved in ion transport, pH regulation, and cellular differentiation. **Clinical Significance** The renal beta-intercalated cell plays a crucial role in maintaining acid-base balance and is essential for the proper functioning of the kidney. Dysfunction of the renal beta-intercalated cell can lead to various clinical conditions, including: * **Metabolic acidosis**: A condition characterized by an excessive accumulation of acid in the blood, which can lead to a range of symptoms, including respiratory acidosis, cardiovascular collapse, and even death. * **Renal tubular acidosis**: A group of disorders that affect the kidneys' ability to regulate acid-base balance, leading to metabolic acidosis. * **Kidney disease**: Dysfunction of the renal beta-intercalated cell can contribute to the development of kidney disease, including chronic kidney disease and end-stage renal disease. In addition to its clinical significance, the renal beta-intercalated cell is also of interest to researchers due to its role in: * **Ion transport and pH regulation**: The renal beta-intercalated cell provides insights into the mechanisms of ion transport and pH regulation in the kidney. * **Cellular signaling**: The renal beta-intercalated cell offers a model for studying cellular signaling pathways involved in ion transport, pH regulation, and cellular differentiation. * **Kidney development and disease**: The renal beta-intercalated cell is an important cell type in kidney development and disease, providing insights into the mechanisms of kidney development and disease.