Details for: CL0002207

Cell ID: CL0002207

Cell Name: brush cell of trachea

Marker Score Threshold: 381
(Derived using integrated single-cell and genomic data)

Description: Brush cell of the epithelium in the trachea.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.95
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.8
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.44
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.42
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.4
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.4
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.36
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.31
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.22
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.19
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.08
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.06
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.05
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.04
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.95
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.92
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.92
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.89
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143933
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.86
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.85
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.8
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.78
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.75
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.72
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.68
    Ensembl ID: ENSG00000169020
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.67
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.63
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.62
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.57
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.56
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.56
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.55
    Ensembl ID: ENSG00000213719
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.53
    Ensembl ID: ENSG00000005022
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.5
    Ensembl ID: ENSG00000131174
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.5
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.48
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.47
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.44
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.43
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.41
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.4
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.38
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.36
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.34
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.34
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.32
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.31
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.28
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.28
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.27
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.24
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.22
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.22
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.2
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.2
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.18
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.16
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.15
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.15
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104763
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.12
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.11
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.11
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.1
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.09
    Ensembl ID: ENSG00000177879
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.07
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164733
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.06
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.02
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CSNK2B (ENSG00000204435)
    Fold Change: 1
    Ensembl ID: ENSG00000204435
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: N/A
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: N/A
    Ensembl ID: ENSG00000141367
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Microvilli**: Brush cells are characterized by the presence of microvilli, which are small, finger-like projections on the surface of the cell. These microvilli increase the surface area of the cell, allowing for more efficient mucus secretion and absorption. 2. **Lack of Desmosomes**: Brush cells do not have desmosomes, which are intercellular junctions that provide mechanical strength to epithelial tissues. This lack of desmosomes allows for greater flexibility and movement of the cell membrane. 3. **Microvillar Structure**: The microvilli of brush cells are composed of actin filaments and are involved in the regulation of mucus secretion and absorption. 4. **Cytoskeletal Organization**: The cytoskeleton of brush cells is composed of actin filaments, microtubules, and intermediate filaments. The actin filaments are particularly important in the regulation of microvilli structure and function. **Clinical Significance** 1. **Respiratory Diseases**: Brush cells play a crucial role in maintaining respiratory homeostasis, and dysfunction of these cells has been implicated in various respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. 2. **Mucus Secretion Regulation**: Brush cells are responsible for regulating mucus secretion and absorption in the respiratory tract. Dysregulation of this process can lead to respiratory problems, such as coughing and wheezing. 3. **Cancer**: Abnormalities in brush cell morphology and function have been observed in certain types of cancer, such as lung cancer and esophageal cancer. 4. **Infectious Diseases**: Brush cells have been shown to play a role in the regulation of immune responses to infectious diseases, such as respiratory syncytial virus (RSV) and influenza. **Pathways/Ontology** Brush cells are involved in a wide range of biological processes, including: 1. **Actin Cytoskeleton**: Brush cells rely on the actin cytoskeleton for the regulation of microvilli structure and function. 2. **Adherens Junctions**: Brush cells lack desmosomes, but they do have adherens junctions, which provide mechanical strength to the cell membrane. 3. **Apical Protein Localization**: Brush cells have specific proteins localized to the apical surface of the cell, which are involved in the regulation of mucus secretion and absorption. 4. **Chromatin Remodeling**: Brush cells have a unique chromatin remodeling system that allows for the regulation of gene expression in response to environmental stimuli. Overall, brush cells play a critical role in maintaining respiratory homeostasis, and their dysfunction has been implicated in various respiratory diseases. Further research is needed to understand the mechanisms underlying brush cell function and to develop new treatments for respiratory diseases.