Details for: CL0002223

Cell ID: CL0002223

Cell Name: anterior lens cell

Marker Score Threshold: 1,345
(Derived using integrated single-cell and genomic data)

Description: A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s).

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 4.47
    Ensembl ID: ENSG00000173406
  • Gene Symbol: COL4A3 (ENSG00000169031)
    Fold Change: 4.46
    Ensembl ID: ENSG00000169031
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 4.44
    Ensembl ID: ENSG00000150672
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 4.43
    Ensembl ID: ENSG00000158560
  • Gene Symbol: IDO1 (ENSG00000131203)
    Fold Change: 4.39
    Ensembl ID: ENSG00000131203
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 4.39
    Ensembl ID: ENSG00000109846
  • Gene Symbol: CRYBB2 (ENSG00000244752)
    Fold Change: 4.36
    Ensembl ID: ENSG00000244752
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 4.34
    Ensembl ID: ENSG00000128585
  • Gene Symbol: FGFR2 (ENSG00000066468)
    Fold Change: 4.31
    Ensembl ID: ENSG00000066468
  • Gene Symbol: AGFG1 (ENSG00000173744)
    Fold Change: 4.3
    Ensembl ID: ENSG00000173744
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 4.28
    Ensembl ID: ENSG00000134871
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 4.24
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ROR1 (ENSG00000185483)
    Fold Change: 4.21
    Ensembl ID: ENSG00000185483
  • Gene Symbol: NTRK2 (ENSG00000148053)
    Fold Change: 4.21
    Ensembl ID: ENSG00000148053
  • Gene Symbol: PDE1C (ENSG00000154678)
    Fold Change: 4.2
    Ensembl ID: ENSG00000154678
  • Gene Symbol: NCAM1 (ENSG00000149294)
    Fold Change: 4.17
    Ensembl ID: ENSG00000149294
  • Gene Symbol: ME1 (ENSG00000065833)
    Fold Change: 4.17
    Ensembl ID: ENSG00000065833
  • Gene Symbol: COL4A5 (ENSG00000188153)
    Fold Change: 4.16
    Ensembl ID: ENSG00000188153
  • Gene Symbol: COL4A4 (ENSG00000081052)
    Fold Change: 4.15
    Ensembl ID: ENSG00000081052
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 4.15
    Ensembl ID: ENSG00000189283
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.12
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CTBP2 (ENSG00000175029)
    Fold Change: 4.06
    Ensembl ID: ENSG00000175029
  • Gene Symbol: INSR (ENSG00000171105)
    Fold Change: 4.06
    Ensembl ID: ENSG00000171105
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 4.04
    Ensembl ID: ENSG00000142192
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 4.03
    Ensembl ID: ENSG00000058866
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 4
    Ensembl ID: ENSG00000140443
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 4
    Ensembl ID: ENSG00000165092
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 3.99
    Ensembl ID: ENSG00000151422
  • Gene Symbol: EPB41L2 (ENSG00000079819)
    Fold Change: 3.99
    Ensembl ID: ENSG00000079819
  • Gene Symbol: PRKN (ENSG00000185345)
    Fold Change: 3.98
    Ensembl ID: ENSG00000185345
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 3.97
    Ensembl ID: ENSG00000198947
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 3.97
    Ensembl ID: ENSG00000178568
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 3.87
    Ensembl ID: ENSG00000140945
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 3.86
    Ensembl ID: ENSG00000170558
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.85
    Ensembl ID: ENSG00000145362
  • Gene Symbol: MEIS2 (ENSG00000134138)
    Fold Change: 3.84
    Ensembl ID: ENSG00000134138
  • Gene Symbol: PAX6 (ENSG00000007372)
    Fold Change: 3.84
    Ensembl ID: ENSG00000007372
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 3.81
    Ensembl ID: ENSG00000074800
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.8
    Ensembl ID: ENSG00000151914
  • Gene Symbol: EGFR (ENSG00000146648)
    Fold Change: 3.79
    Ensembl ID: ENSG00000146648
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.79
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CRYGS (ENSG00000213139)
    Fold Change: 3.77
    Ensembl ID: ENSG00000213139
  • Gene Symbol: GLDC (ENSG00000178445)
    Fold Change: 3.76
    Ensembl ID: ENSG00000178445
  • Gene Symbol: EYA4 (ENSG00000112319)
    Fold Change: 3.7
    Ensembl ID: ENSG00000112319
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 3.69
    Ensembl ID: ENSG00000198589
  • Gene Symbol: GPC5 (ENSG00000179399)
    Fold Change: 3.68
    Ensembl ID: ENSG00000179399
  • Gene Symbol: NF1 (ENSG00000196712)
    Fold Change: 3.64
    Ensembl ID: ENSG00000196712
  • Gene Symbol: GSPT1 (ENSG00000103342)
    Fold Change: 3.6
    Ensembl ID: ENSG00000103342
  • Gene Symbol: FAT1 (ENSG00000083857)
    Fold Change: 3.58
    Ensembl ID: ENSG00000083857
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 3.58
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 3.55
    Ensembl ID: ENSG00000099204
  • Gene Symbol: COL4A6 (ENSG00000197565)
    Fold Change: 3.53
    Ensembl ID: ENSG00000197565
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 3.53
    Ensembl ID: ENSG00000257923
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.51
    Ensembl ID: ENSG00000135046
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 3.51
    Ensembl ID: ENSG00000144674
  • Gene Symbol: CRYBA4 (ENSG00000196431)
    Fold Change: 3.44
    Ensembl ID: ENSG00000196431
  • Gene Symbol: SMAD2 (ENSG00000175387)
    Fold Change: 3.44
    Ensembl ID: ENSG00000175387
  • Gene Symbol: NKTR (ENSG00000114857)
    Fold Change: 3.43
    Ensembl ID: ENSG00000114857
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 3.4
    Ensembl ID: ENSG00000092964
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.39
    Ensembl ID: ENSG00000198363
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 3.34
    Ensembl ID: ENSG00000187498
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 3.34
    Ensembl ID: ENSG00000196482
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.34
    Ensembl ID: ENSG00000084234
  • Gene Symbol: PCDH7 (ENSG00000169851)
    Fold Change: 3.32
    Ensembl ID: ENSG00000169851
  • Gene Symbol: MYO5B (ENSG00000167306)
    Fold Change: 3.29
    Ensembl ID: ENSG00000167306
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 3.28
    Ensembl ID: ENSG00000126777
  • Gene Symbol: CNN3 (ENSG00000117519)
    Fold Change: 3.28
    Ensembl ID: ENSG00000117519
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 3.28
    Ensembl ID: ENSG00000145012
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 3.28
    Ensembl ID: ENSG00000196730
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 3.27
    Ensembl ID: ENSG00000169862
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 3.25
    Ensembl ID: ENSG00000141837
  • Gene Symbol: AFF1 (ENSG00000172493)
    Fold Change: 3.23
    Ensembl ID: ENSG00000172493
  • Gene Symbol: NR6A1 (ENSG00000148200)
    Fold Change: 3.21
    Ensembl ID: ENSG00000148200
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 3.19
    Ensembl ID: ENSG00000134769
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 3.16
    Ensembl ID: ENSG00000152578
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 3.14
    Ensembl ID: ENSG00000147862
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 3.14
    Ensembl ID: ENSG00000047849
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.12
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 3.1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 3.06
    Ensembl ID: ENSG00000075711
  • Gene Symbol: BTD (ENSG00000169814)
    Fold Change: 3.06
    Ensembl ID: ENSG00000169814
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3
    Ensembl ID: ENSG00000140836
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 3
    Ensembl ID: ENSG00000083123
  • Gene Symbol: HIF1A (ENSG00000100644)
    Fold Change: 3
    Ensembl ID: ENSG00000100644
  • Gene Symbol: SMAD3 (ENSG00000166949)
    Fold Change: 2.99
    Ensembl ID: ENSG00000166949
  • Gene Symbol: PAM (ENSG00000145730)
    Fold Change: 2.97
    Ensembl ID: ENSG00000145730
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.97
    Ensembl ID: ENSG00000263001
  • Gene Symbol: ELF2 (ENSG00000109381)
    Fold Change: 2.95
    Ensembl ID: ENSG00000109381
  • Gene Symbol: P4HA1 (ENSG00000122884)
    Fold Change: 2.94
    Ensembl ID: ENSG00000122884
  • Gene Symbol: CRYBA2 (ENSG00000163499)
    Fold Change: 2.93
    Ensembl ID: ENSG00000163499
  • Gene Symbol: PDE4D (ENSG00000113448)
    Fold Change: 2.92
    Ensembl ID: ENSG00000113448
  • Gene Symbol: FANCC (ENSG00000158169)
    Fold Change: 2.92
    Ensembl ID: ENSG00000158169
  • Gene Symbol: FLNB (ENSG00000136068)
    Fold Change: 2.91
    Ensembl ID: ENSG00000136068
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 2.91
    Ensembl ID: ENSG00000044115
  • Gene Symbol: NHS (ENSG00000188158)
    Fold Change: 2.87
    Ensembl ID: ENSG00000188158
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2.86
    Ensembl ID: ENSG00000149311
  • Gene Symbol: SCARB1 (ENSG00000073060)
    Fold Change: 2.86
    Ensembl ID: ENSG00000073060
  • Gene Symbol: PAFAH1B1 (ENSG00000007168)
    Fold Change: 2.83
    Ensembl ID: ENSG00000007168
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.81
    Ensembl ID: ENSG00000097007
  • Gene Symbol: NFIX (ENSG00000008441)
    Fold Change: 2.81
    Ensembl ID: ENSG00000008441

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in anterior lens cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in anterior lens cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Anterior lens cell: A type of simple cuboidal epithelial cell found on the anterior surface of the lens in the eye. * Lens fiber cell: The cell has the ability to transform into lens fibers, which are essential for the development and maintenance of the lens. * Gene expression: The cell contains several genes, including DAB1, COL4A3, DLG2, DYNC1I1, IDO1, and CRYAB, which are involved in various cellular processes. * Pathways and ontologies: The cell is involved in adult walking behavior, astrocyte differentiation, axonogenesis, and nervous system development, highlighting its importance in the development and function of the nervous system. **Clinical Significance** * Lens development and maintenance: The anterior lens cell plays a crucial role in the development and maintenance of the lens, and its dysfunction can lead to lens-related disorders such as cataracts. * Nervous system development: The cell's involvement in nervous system development highlights its importance in the development and function of the nervous system, and its dysfunction can lead to neurological disorders. * Immune system regulation: The cell's expression of IDO1, a protein involved in immune system regulation, suggests that it plays a role in immune system modulation and may be involved in immune-related disorders. * Cancer research: The cell's expression of DYNC1I1, a protein involved in cell cycle regulation, suggests that it may be involved in cancer research, particularly in the study of cell cycle regulation and cancer cell proliferation. **Potential Applications** * Lens transplantation: Understanding the biology of the anterior lens cell could lead to the development of more effective lens transplantation techniques. * Nervous system disorders: Studying the cell's involvement in nervous system development and function could lead to the development of new treatments for nervous system disorders such as Alzheimer's disease and Parkinson's disease. * Immune system modulation: The cell's expression of IDO1 suggests that it may be involved in immune system modulation, and understanding its role could lead to the development of new treatments for immune-related disorders. * Cancer research: The cell's expression of DYNC1I1 suggests that it may be involved in cancer cell proliferation, and understanding its role could lead to the development of new treatments for cancer.