Details for: CL0002223

Cell ID: CL0002223

Cell Name: anterior lens cell

Marker Score Threshold: 1345
(Derived using integrated single-cell and genomic data)

Description: A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s).

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 4.24
    Ensembl ID: ENSG00000151150
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.12
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 4.04
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 4
    Ensembl ID: ENSG00000165092
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 3.86
    Ensembl ID: ENSG00000170558
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.85
    Ensembl ID: ENSG00000145362
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.8
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.79
    Ensembl ID: ENSG00000182718
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 3.69
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 3.58
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.51
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.39
    Ensembl ID: ENSG00000198363
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.34
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 3.25
    Ensembl ID: ENSG00000141837
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.12
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 3.1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BTD (ENSG00000169814)
    Fold Change: 3.06
    Ensembl ID: ENSG00000169814
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3
    Ensembl ID: ENSG00000140836
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 3
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2.86
    Ensembl ID: ENSG00000149311
  • Gene Symbol: SCARB1 (ENSG00000073060)
    Fold Change: 2.86
    Ensembl ID: ENSG00000073060
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.81
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.81
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.76
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.75
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.65
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 2.52
    Ensembl ID: ENSG00000154162
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.52
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.48
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.45
    Ensembl ID: ENSG00000113916
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.41
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.4
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.33
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.33
    Ensembl ID: ENSG00000156110
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 2.31
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.29
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.11
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.1
    Ensembl ID: ENSG00000153113
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 2.05
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ALAD (ENSG00000148218)
    Fold Change: 2.01
    Ensembl ID: ENSG00000148218
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.93
    Ensembl ID: ENSG00000102699
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.9
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CCNC (ENSG00000112237)
    Fold Change: 1.9
    Ensembl ID: ENSG00000112237
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.9
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.89
    Ensembl ID: ENSG00000131269
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.88
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.85
    Ensembl ID: ENSG00000107779
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.85
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.84
    Ensembl ID: ENSG00000004897
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.81
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.76
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.75
    Ensembl ID: ENSG00000087274
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.71
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.7
    Ensembl ID: ENSG00000076555
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 1.67
    Ensembl ID: ENSG00000236824
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.62
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.58
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.53
    Ensembl ID: ENSG00000145349
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.53
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CBR1 (ENSG00000159228)
    Fold Change: 1.52
    Ensembl ID: ENSG00000159228
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.5
    Ensembl ID: ENSG00000171552
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.48
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.47
    Ensembl ID: ENSG00000010278
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.47
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.45
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.44
    Ensembl ID: ENSG00000125864
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.43
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.37
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100852
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.34
    Ensembl ID: ENSG00000148660
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.3
    Ensembl ID: ENSG00000035687
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.3
    Ensembl ID: ENSG00000114423
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.28
    Ensembl ID: ENSG00000004455
  • Gene Symbol: OSGIN2 (ENSG00000164823)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164823
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.24
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.22
    Ensembl ID: ENSG00000091879
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.21
    Ensembl ID: ENSG00000082258
  • Gene Symbol: ARVCF (ENSG00000099889)
    Fold Change: 1.21
    Ensembl ID: ENSG00000099889
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196975
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.18
    Ensembl ID: ENSG00000101846
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.18
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.17
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BBS4 (ENSG00000140463)
    Fold Change: 1.17
    Ensembl ID: ENSG00000140463
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.15
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.13
    Ensembl ID: ENSG00000079102
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.12
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.09
    Ensembl ID: ENSG00000033627
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 1.09
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.09
    Ensembl ID: ENSG00000128595
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.08
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.07
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.07
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.06
    Ensembl ID: ENSG00000167601
  • Gene Symbol: BRCA1 (ENSG00000012048)
    Fold Change: 1.06
    Ensembl ID: ENSG00000012048
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.01
    Ensembl ID: ENSG00000105221
  • Gene Symbol: CBL (ENSG00000110395)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110395
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Anterior lens cell 2. **Gene Symbol**: ANK3 3. **Ensembl ID**: ENSG00000151150 4. **Cell Transformation**: Transforms into lens fiber(s) 5. **Cellular Processes**: * Asparagine n-linked glycosylation * Axon guidance * Regulation of potassium ion transport * Regulation of gene expression * Regulation of protein localization * Regulation of protein targeting to membrane 6. **Pathways and Ontology**: * Asparagine n-linked glycosylation * Axon guidance * Axonogenesis * Basal plasma membrane * Basolateral plasma membrane * Bicellular tight junction * Cadherin binding * Cell surface * Cellular response to magnesium ion * Copi-mediated anterograde transport * Costamere * Cytoskeletal anchor activity * Cytoskeletal protein binding * Cytoskeleton organization * Cytosol * Dendrite * Developmental biology * Endoplasmic reticulum * Er to golgi anterograde transport * Establishment of protein localization * Golgi apparatus * Golgi to plasma membrane protein transport * Interaction between L1 and ankyrins * L1cam interactions * Lateral plasma membrane * Lysosome * Magnesium ion homeostasis * Maintenance of protein location in plasma membrane * Membrane assembly * Membrane trafficking * Metabolism of proteins * Mitotic cytokinesis * Negative regulation of delayed rectifier potassium channel activity * Nervous system development * Neuromuscular junction * Neuromuscular junction development * Neuronal action potential * Neuron projection * Node of Ranvier * Plasma membrane * Plasma membrane organization * Positive regulation of cation channel activity * Positive regulation of cell communication by electrical coupling * Positive regulation of gene expression * Positive regulation of homotypic cell-cell adhesion * Positive regulation of membrane depolarization during cardiac muscle cell action potential * Positive regulation of membrane potential * Positive regulation of protein targeting to membrane * Positive regulation of sodium ion transmembrane transporter activity * Positive regulation of sodium ion transport * Post-translational protein modification * Postsynaptic membrane * Protein-macromolecule adaptor activity * Protein binding * Protein localization to axon * Protein localization to plasma membrane * Regulation of potassium ion transport * Sarcolemma * Sarcoplasmic reticulum * Signal transduction * Spectrin-associated cytoskeleton * Spectrin binding * Structural constituent of cytoskeleton * T-tubule * Transmembrane transporter binding * Transport to the golgi and subsequent modification * Vesicle-mediated transport * Z disc **Clinical Significance** The anterior lens cell's transformation into a lens fiber is crucial for the lens's structure and function. Abnormalities in this process can lead to various eye disorders, including cataracts. The cell's pathways and ontology are involved in various cellular processes, including regulation of gene expression, regulation of protein localization, and regulation of protein targeting to membrane. Understanding the cell's characteristics and clinical significance can provide insights into the development of new treatments for eye disorders. **References** * [Insert references here] Note: The information provided is a summary of the cell's characteristics and clinical significance, and is not intended to be a comprehensive review of the cell's literature.