Details for: CL0002224

Cell ID: CL0002224

Cell Name: lens epithelial cell

Marker Score Threshold: 1210
(Derived using integrated single-cell and genomic data)

Description: A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.93
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.86
    Ensembl ID: ENSG00000145362
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.72
    Ensembl ID: ENSG00000142192
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.69
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.62
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.61
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.56
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.51
    Ensembl ID: ENSG00000151150
  • Gene Symbol: SCARB1 (ENSG00000073060)
    Fold Change: 3.14
    Ensembl ID: ENSG00000073060
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.99
    Ensembl ID: ENSG00000198363
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2.99
    Ensembl ID: ENSG00000083123
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.97
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.97
    Ensembl ID: ENSG00000140836
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.95
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.93
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.92
    Ensembl ID: ENSG00000137845
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.89
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.73
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.73
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BTD (ENSG00000169814)
    Fold Change: 2.71
    Ensembl ID: ENSG00000169814
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2.69
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.66
    Ensembl ID: ENSG00000171791
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 2.64
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.63
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.49
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.4
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.38
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.37
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.35
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.33
    Ensembl ID: ENSG00000278540
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.33
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135046
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.2
    Ensembl ID: ENSG00000101384
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.18
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 2.14
    Ensembl ID: ENSG00000197381
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.14
    Ensembl ID: ENSG00000168675
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.14
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CBR1 (ENSG00000159228)
    Fold Change: 2.09
    Ensembl ID: ENSG00000159228
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 2.05
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CCNC (ENSG00000112237)
    Fold Change: 1.96
    Ensembl ID: ENSG00000112237
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.92
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.9
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALAD (ENSG00000148218)
    Fold Change: 1.89
    Ensembl ID: ENSG00000148218
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.86
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.85
    Ensembl ID: ENSG00000133639
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.84
    Ensembl ID: ENSG00000183020
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.8
    Ensembl ID: ENSG00000077549
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.75
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.74
    Ensembl ID: ENSG00000091879
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.73
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.72
    Ensembl ID: ENSG00000159842
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.71
    Ensembl ID: ENSG00000141837
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.68
    Ensembl ID: ENSG00000148090
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.68
    Ensembl ID: ENSG00000125864
  • Gene Symbol: OSGIN2 (ENSG00000164823)
    Fold Change: 1.67
    Ensembl ID: ENSG00000164823
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.65
    Ensembl ID: ENSG00000100852
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.64
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.61
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.55
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.53
    Ensembl ID: ENSG00000131269
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.51
    Ensembl ID: ENSG00000110092
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 1.5
    Ensembl ID: ENSG00000236824
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.48
    Ensembl ID: ENSG00000153956
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.44
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143437
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.43
    Ensembl ID: ENSG00000148660
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.4
    Ensembl ID: ENSG00000138175
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.4
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.38
    Ensembl ID: ENSG00000076555
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.35
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.33
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.33
    Ensembl ID: ENSG00000072110
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.31
    Ensembl ID: ENSG00000102699
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134982
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.25
    Ensembl ID: ENSG00000079102
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.23
    Ensembl ID: ENSG00000122729
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.2
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.19
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164904
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.18
    Ensembl ID: ENSG00000082258
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.18
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.18
    Ensembl ID: ENSG00000035687
  • Gene Symbol: BBS4 (ENSG00000140463)
    Fold Change: 1.17
    Ensembl ID: ENSG00000140463
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.15
    Ensembl ID: ENSG00000058668
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.13
    Ensembl ID: ENSG00000162433
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.13
    Ensembl ID: ENSG00000010278
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.12
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ARVCF (ENSG00000099889)
    Fold Change: 1.1
    Ensembl ID: ENSG00000099889
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143153
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.07
    Ensembl ID: ENSG00000183044
  • Gene Symbol: BCL2L2 (ENSG00000129473)
    Fold Change: 1.06
    Ensembl ID: ENSG00000129473
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000171552
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BRCA1 (ENSG00000012048)
    Fold Change: 1.05
    Ensembl ID: ENSG00000012048
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107282
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128595
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.02
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.02
    Ensembl ID: ENSG00000033627
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: The LE Cell is located on the surface of the lens, covering the entire lens surface. 2. **Shape**: The LE Cell is cuboidal in shape, with a flat, rectangular shape. 3. **Function**: The LE Cell plays a crucial role in maintaining the homeostatic functions of the lens, including regulating ion and nutrient transport, and producing new lens fibers. 4. **Cell Signaling**: The LE Cell expresses a variety of signaling molecules, including Na+/K+ ATPase pumps, which help regulate ion transport and cell growth. 5. **Cellular Structure**: The LE Cell has a characteristic structure, with a large nucleus and a cytoplasm rich in organelles, including mitochondria, endoplasmic reticulum, and Golgi apparatus. 6. **Progenitor Activity**: The LE Cell serves as a progenitor for new lens fibers, constantly laying down fibers throughout life. **Clinical Significance** 1. **Cataract Formation**: Dysfunction of the LE Cell has been implicated in the formation of cataracts, a leading cause of vision loss worldwide. 2. **Glaucoma**: The LE Cell is also involved in the regulation of intraocular pressure, and dysfunction of the LE Cell has been linked to glaucoma, a leading cause of vision loss in older adults. 3. **Lens Opacification**: The LE Cell plays a crucial role in maintaining the transparency of the lens, and dysfunction of the LE Cell can lead to lens opacification, a condition that can cause vision loss. 4. **Eye Development**: The LE Cell is involved in the regulation of lens growth and development, and its dysfunction can lead to abnormalities in eye development. 5. **Neurological Disorders**: The LE Cell has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). **Genes Associated with Lens Epithelial Cells** 1. **RERE (RER Expressing Enriched in Ectodermal cells)**: This gene is involved in the regulation of lens development and growth. 2. **ANK2 (Ankyrin Repeat Domain Containing 2)**: This gene is involved in the regulation of ion transport and cell growth in the LE Cell. 3. **APP (Amyloid Precursor Protein)**: This gene is involved in the regulation of amyloid fibril formation and is implicated in Alzheimer's disease. In conclusion, the Lens Epithelial Cell is a critical component of the eye, playing a crucial role in maintaining the homeostatic functions of the lens, regulating ion and nutrient transport, and producing new lens fibers. Dysfunction of the LE Cell has been implicated in various eye disorders, including cataract formation, glaucoma, and lens opacification. Further research is needed to fully understand the role of the LE Cell in eye development and disease.