Details for: CL0002225

Cell ID: CL0002225

Cell Name: secondary lens fiber

Marker Score Threshold: 585
(Derived using integrated single-cell and genomic data)

Description: A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded.

Synonyms: secondary lens fibre

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.81
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.76
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.74
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.7
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.68
    Ensembl ID: ENSG00000151746
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 2.67
    Ensembl ID: ENSG00000130294
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.63
    Ensembl ID: ENSG00000142599
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.61
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.57
    Ensembl ID: ENSG00000278540
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.56
    Ensembl ID: ENSG00000163697
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 2.54
    Ensembl ID: ENSG00000176171
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.49
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.48
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.48
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 2.45
    Ensembl ID: ENSG00000125864
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 2.41
    Ensembl ID: ENSG00000183020
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.35
    Ensembl ID: ENSG00000084234
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.34
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ARVCF (ENSG00000099889)
    Fold Change: 2.29
    Ensembl ID: ENSG00000099889
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.28
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.25
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.24
    Ensembl ID: ENSG00000165092
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.24
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.23
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.22
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.22
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.13
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.08
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BTD (ENSG00000169814)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169814
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.05
    Ensembl ID: ENSG00000171791
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.04
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.03
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 2.02
    Ensembl ID: ENSG00000236824
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.99
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.99
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.97
    Ensembl ID: ENSG00000140836
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.96
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.95
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.95
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.87
    Ensembl ID: ENSG00000161798
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.85
    Ensembl ID: ENSG00000166710
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.83
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.8
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.76
    Ensembl ID: ENSG00000081181
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.75
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.7
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.7
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.68
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.66
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.62
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.6
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143153
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 1.57
    Ensembl ID: ENSG00000070808
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.57
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARHGAP1 (ENSG00000175220)
    Fold Change: 1.57
    Ensembl ID: ENSG00000175220
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.54
    Ensembl ID: ENSG00000135298
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.5
    Ensembl ID: ENSG00000078053
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.5
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.5
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.47
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.45
    Ensembl ID: ENSG00000145349
  • Gene Symbol: BCL2L2 (ENSG00000129473)
    Fold Change: 1.43
    Ensembl ID: ENSG00000129473
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.4
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.37
    Ensembl ID: ENSG00000143437
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.37
    Ensembl ID: ENSG00000148660
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.35
    Ensembl ID: ENSG00000131269
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.29
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.26
    Ensembl ID: ENSG00000183044
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.24
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.24
    Ensembl ID: ENSG00000091879
  • Gene Symbol: BRCA1 (ENSG00000012048)
    Fold Change: 1.24
    Ensembl ID: ENSG00000012048
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159842
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.21
    Ensembl ID: ENSG00000123505
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.21
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.2
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.17
    Ensembl ID: ENSG00000175054
  • Gene Symbol: BBS4 (ENSG00000140463)
    Fold Change: 1.17
    Ensembl ID: ENSG00000140463
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.16
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.16
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.15
    Ensembl ID: ENSG00000121989
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.15
    Ensembl ID: ENSG00000105552
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.14
    Ensembl ID: ENSG00000186716
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.13
    Ensembl ID: ENSG00000168374
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.13
    Ensembl ID: ENSG00000183255
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.11
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.1
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.09
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 1.08
    Ensembl ID: ENSG00000167434
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.08
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.06
    Ensembl ID: ENSG00000075624
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.05
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.03
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.03
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1
    Ensembl ID: ENSG00000171552

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in secondary lens fiber cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in secondary lens fiber cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The secondary lens fiber cell is characterized by the following key features: 1. **Location**: The cell is located towards the center of the lens, which is the avascular region of the lens. 2. **Cell Organelles**: The cell organelles are normally degraded or in the process of being degraded, which is a characteristic feature of secondary lens fiber cells. 3. **Gene Expression**: The genes associated with this cell, including ANK2, CALD1, and DST, play important roles in the development and function of the lens. 4. **Cytoskeleton Organization**: The cytoskeleton of the secondary lens fiber cell is organized in a way that allows for the proper functioning of the lens. 5. **Actin Binding**: The cell binds to actin, which is an important component of the cytoskeleton. **Clinical Significance** The secondary lens fiber cell plays an important role in the development and function of the lens, and any abnormalities in the cell can lead to various clinical disorders. Some of the clinical significance of the secondary lens fiber cell includes: 1. **Cataract Formation**: Abnormalities in the secondary lens fiber cell can lead to the formation of cataracts, which are cloudy areas in the lens that can impair vision. 2. **Lens Opacification**: Secondary lens fiber cells are involved in the regulation of lens opacification, which is the process by which the lens becomes cloudy due to the accumulation of waste products. 3. **Lens Development**: The secondary lens fiber cell plays an important role in the development of the lens, and abnormalities in the cell can lead to developmental disorders. 4. **Eye Diseases**: Abnormalities in the secondary lens fiber cell can also lead to various eye diseases, including glaucoma and age-related macular degeneration. In conclusion, the secondary lens fiber cell is an important component of the lens, and any abnormalities in the cell can lead to various clinical disorders. Further research is needed to fully understand the role of the secondary lens fiber cell in the development and function of the lens, and to develop new treatments for eye diseases caused by abnormalities in this cell.