Details for: CL0002241

Cell ID: CL0002241

Cell Name: pulmonary interstitial fibroblast

Marker Score Threshold: 800
(Derived using integrated single-cell and genomic data)

Description: A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.

Synonyms: pulmonary myofibroblast, pulmonary septal cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: S1PR1 (ENSG00000170989)
    Fold Change: 9.25
    Ensembl ID: ENSG00000170989
  • Gene Symbol: CDO1 (ENSG00000129596)
    Fold Change: 7.3
    Ensembl ID: ENSG00000129596
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: 6.3
    Ensembl ID: ENSG00000112175
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 6.13
    Ensembl ID: ENSG00000154188
  • Gene Symbol: EDNRA (ENSG00000151617)
    Fold Change: 5.2
    Ensembl ID: ENSG00000151617
  • Gene Symbol: COL13A1 (ENSG00000197467)
    Fold Change: 5.01
    Ensembl ID: ENSG00000197467
  • Gene Symbol: BMP4 (ENSG00000125378)
    Fold Change: 4.61
    Ensembl ID: ENSG00000125378
  • Gene Symbol: EFNB1 (ENSG00000090776)
    Fold Change: 4.4
    Ensembl ID: ENSG00000090776
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 4.22
    Ensembl ID: ENSG00000108381
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 4.02
    Ensembl ID: ENSG00000129244
  • Gene Symbol: CA3 (ENSG00000164879)
    Fold Change: 3.96
    Ensembl ID: ENSG00000164879
  • Gene Symbol: DBN1 (ENSG00000113758)
    Fold Change: 3.96
    Ensembl ID: ENSG00000113758
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 3.53
    Ensembl ID: ENSG00000144891
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 3.41
    Ensembl ID: ENSG00000018236
  • Gene Symbol: COL4A5 (ENSG00000188153)
    Fold Change: 3.29
    Ensembl ID: ENSG00000188153
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 3.28
    Ensembl ID: ENSG00000111276
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 3.27
    Ensembl ID: ENSG00000158560
  • Gene Symbol: DACH1 (ENSG00000276644)
    Fold Change: 3.24
    Ensembl ID: ENSG00000276644
  • Gene Symbol: DLX5 (ENSG00000105880)
    Fold Change: 3.02
    Ensembl ID: ENSG00000105880
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.99
    Ensembl ID: ENSG00000107779
  • Gene Symbol: DNMT3A (ENSG00000119772)
    Fold Change: 2.79
    Ensembl ID: ENSG00000119772
  • Gene Symbol: BLMH (ENSG00000108578)
    Fold Change: 2.77
    Ensembl ID: ENSG00000108578
  • Gene Symbol: CCNG2 (ENSG00000138764)
    Fold Change: 2.67
    Ensembl ID: ENSG00000138764
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 2.66
    Ensembl ID: ENSG00000152495
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 2.65
    Ensembl ID: ENSG00000128656
  • Gene Symbol: EDNRB (ENSG00000136160)
    Fold Change: 2.45
    Ensembl ID: ENSG00000136160
  • Gene Symbol: RCBTB2 (ENSG00000136161)
    Fold Change: 2.42
    Ensembl ID: ENSG00000136161
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 2.33
    Ensembl ID: ENSG00000137752
  • Gene Symbol: CNTFR (ENSG00000122756)
    Fold Change: 2.27
    Ensembl ID: ENSG00000122756
  • Gene Symbol: CYP3A5 (ENSG00000106258)
    Fold Change: 2.24
    Ensembl ID: ENSG00000106258
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.24
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135298
  • Gene Symbol: DRG2 (ENSG00000108591)
    Fold Change: 2.06
    Ensembl ID: ENSG00000108591
  • Gene Symbol: CISH (ENSG00000114737)
    Fold Change: 2.01
    Ensembl ID: ENSG00000114737
  • Gene Symbol: COX11 (ENSG00000166260)
    Fold Change: 2
    Ensembl ID: ENSG00000166260
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACP2 (ENSG00000134575)
    Fold Change: 1.96
    Ensembl ID: ENSG00000134575
  • Gene Symbol: CRAT (ENSG00000095321)
    Fold Change: 1.94
    Ensembl ID: ENSG00000095321
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.94
    Ensembl ID: ENSG00000134982
  • Gene Symbol: DFFA (ENSG00000160049)
    Fold Change: 1.92
    Ensembl ID: ENSG00000160049
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 1.88
    Ensembl ID: ENSG00000075711
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.75
    Ensembl ID: ENSG00000119640
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 1.74
    Ensembl ID: ENSG00000248098
  • Gene Symbol: BPHL (ENSG00000137274)
    Fold Change: 1.7
    Ensembl ID: ENSG00000137274
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.69
    Ensembl ID: ENSG00000183020
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.69
    Ensembl ID: ENSG00000113595
  • Gene Symbol: DTYMK (ENSG00000168393)
    Fold Change: 1.67
    Ensembl ID: ENSG00000168393
  • Gene Symbol: NUDT2 (ENSG00000164978)
    Fold Change: 1.61
    Ensembl ID: ENSG00000164978
  • Gene Symbol: CDKN2C (ENSG00000123080)
    Fold Change: 1.57
    Ensembl ID: ENSG00000123080
  • Gene Symbol: DXO (ENSG00000204348)
    Fold Change: 1.56
    Ensembl ID: ENSG00000204348
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.54
    Ensembl ID: ENSG00000131269
  • Gene Symbol: DSG2 (ENSG00000046604)
    Fold Change: 1.52
    Ensembl ID: ENSG00000046604
  • Gene Symbol: CASP6 (ENSG00000138794)
    Fold Change: 1.51
    Ensembl ID: ENSG00000138794
  • Gene Symbol: BOK (ENSG00000176720)
    Fold Change: 1.49
    Ensembl ID: ENSG00000176720
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: MRPL49 (ENSG00000149792)
    Fold Change: 1.41
    Ensembl ID: ENSG00000149792
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.38
    Ensembl ID: ENSG00000156508
  • Gene Symbol: ASNS (ENSG00000070669)
    Fold Change: 1.37
    Ensembl ID: ENSG00000070669
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.36
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.34
    Ensembl ID: ENSG00000126522
  • Gene Symbol: BBS4 (ENSG00000140463)
    Fold Change: 1.33
    Ensembl ID: ENSG00000140463
  • Gene Symbol: PHC1 (ENSG00000111752)
    Fold Change: 1.33
    Ensembl ID: ENSG00000111752
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.26
    Ensembl ID: ENSG00000156110
  • Gene Symbol: DPAGT1 (ENSG00000172269)
    Fold Change: 1.25
    Ensembl ID: ENSG00000172269
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1.23
    Ensembl ID: ENSG00000023330
  • Gene Symbol: DCK (ENSG00000156136)
    Fold Change: 1.23
    Ensembl ID: ENSG00000156136
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.22
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CRKL (ENSG00000099942)
    Fold Change: 1.21
    Ensembl ID: ENSG00000099942
  • Gene Symbol: BMP7 (ENSG00000101144)
    Fold Change: 1.21
    Ensembl ID: ENSG00000101144
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.19
    Ensembl ID: ENSG00000131143
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.18
    Ensembl ID: ENSG00000204580
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.18
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.17
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.17
    Ensembl ID: ENSG00000127184
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: DDX11 (ENSG00000013573)
    Fold Change: 1.15
    Ensembl ID: ENSG00000013573
  • Gene Symbol: ALAD (ENSG00000148218)
    Fold Change: 1.14
    Ensembl ID: ENSG00000148218
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.13
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BCL9 (ENSG00000116128)
    Fold Change: 1.13
    Ensembl ID: ENSG00000116128
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CHRNB1 (ENSG00000170175)
    Fold Change: 1.11
    Ensembl ID: ENSG00000170175
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CLK2 (ENSG00000176444)
    Fold Change: 1.09
    Ensembl ID: ENSG00000176444
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: 1.08
    Ensembl ID: ENSG00000243989
  • Gene Symbol: ERCC8 (ENSG00000049167)
    Fold Change: 1.08
    Ensembl ID: ENSG00000049167
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.08
    Ensembl ID: ENSG00000083123
  • Gene Symbol: CSPG4 (ENSG00000173546)
    Fold Change: 1.06
    Ensembl ID: ENSG00000173546
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.06
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.04
    Ensembl ID: ENSG00000135390
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 1.04
    Ensembl ID: ENSG00000106976
  • Gene Symbol: CHM (ENSG00000188419)
    Fold Change: 1.03
    Ensembl ID: ENSG00000188419
  • Gene Symbol: SARDH (ENSG00000123453)
    Fold Change: 1.03
    Ensembl ID: ENSG00000123453
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.02
    Ensembl ID: ENSG00000156976
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CSTF2 (ENSG00000101811)
    Fold Change: 1.02
    Ensembl ID: ENSG00000101811
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.01
    Ensembl ID: ENSG00000133639
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Pulmonary interstitial fibroblasts are found in the interstitial spaces of the pulmonary tract. 2. **Function**: These cells play a role in the development and maintenance of lung tissue, as well as the regulation of inflammation and immune response. 3. **Gene Symbol**: S1PR1. 4. **Functionality**: Pulmonary interstitial fibroblasts are involved in various cellular processes, including cell adhesion, migration, and proliferation. 5. **Clinical Significance**: In idiopathic pulmonary fibrosis, pulmonary interstitial fibroblasts are known to be overactive, contributing to the fibrotic process. 6. **Regulation**: These cells regulate the expression of genes involved in inflammation, immune response, and tissue repair. **Clinical Significance** 1. **Idiopathic Pulmonary Fibrosis**: Pulmonary interstitial fibroblasts play a crucial role in the development and progression of idiopathic pulmonary fibrosis, a condition characterized by scarring of the lung tissue. 2. **Inflammation and Immune Response**: These cells regulate the expression of genes involved in inflammation and immune response, which is essential for the maintenance of lung tissue health. 3. **Tissue Repair**: Pulmonary interstitial fibroblasts also regulate the expression of genes involved in tissue repair, which is essential for the maintenance of lung tissue health. 4. **Potential Therapeutic Targets**: The dysregulation of pulmonary interstitial fibroblasts in idiopathic pulmonary fibrosis highlights the potential for these cells as therapeutic targets for the treatment of this disease. **Pathways and Ontologies** 1. **Actin Cytoskeleton Organization**: Pulmonary interstitial fibroblasts regulate the expression of genes involved in actin cytoskeleton organization, which is essential for cell migration and proliferation. 2. **Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway**: These cells regulate the expression of genes involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway, which is essential for cell proliferation and migration. 3. **Angiogenesis**: Pulmonary interstitial fibroblasts regulate the expression of genes involved in angiogenesis, which is essential for the development of new blood vessels. 4. **Inflammatory Response**: These cells regulate the expression of genes involved in inflammatory response, which is essential for the maintenance of lung tissue health. In conclusion, pulmonary interstitial fibroblasts play a crucial role in the development and maintenance of lung tissue, as well as the regulation of inflammation and immune response. The dysregulation of these cells in idiopathic pulmonary fibrosis highlights the potential for these cells as therapeutic targets for the treatment of this disease.