Details for: CL0002250

Cell ID: CL0002250

Cell Name: intestinal crypt stem cell

Marker Score Threshold: 376
(Derived using integrated single-cell and genomic data)

Description: A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells.

Synonyms: stem cell of intestinal crypt of Lieberkuhn

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.73
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.73
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.62
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.6
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.55
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.47
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.46
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.43
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.38
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.37
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.33
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.33
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.32
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.27
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.26
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.23
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.22
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.2
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.18
    Ensembl ID: ENSG00000134825
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.14
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.13
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.12
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.07
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.06
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.04
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.03
    Ensembl ID: ENSG00000127022
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.01
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.99
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.99
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.98
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 1.96
    Ensembl ID: ENSG00000248144
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.93
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.93
    Ensembl ID: ENSG00000072778
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.88
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.86
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.82
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.78
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.75
    Ensembl ID: ENSG00000111275
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.75
    Ensembl ID: ENSG00000108561
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.73
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.72
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.69
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.68
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.62
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 1.62
    Ensembl ID: ENSG00000118137
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.57
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.57
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.56
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.55
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.54
    Ensembl ID: ENSG00000196975
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.5
    Ensembl ID: ENSG00000149823
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.49
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.48
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.48
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.46
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.45
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.42
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.38
    Ensembl ID: ENSG00000175164
  • Gene Symbol: APOA4 (ENSG00000110244)
    Fold Change: 1.38
    Ensembl ID: ENSG00000110244
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.37
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.34
    Ensembl ID: ENSG00000014216
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.3
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.29
    Ensembl ID: ENSG00000160710
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.28
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.27
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.25
    Ensembl ID: ENSG00000130707
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.25
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.25
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.24
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.24
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.24
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.22
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 1.22
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ASCL2 (ENSG00000183734)
    Fold Change: 1.17
    Ensembl ID: ENSG00000183734
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.15
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.15
    Ensembl ID: ENSG00000162772
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.13
    Ensembl ID: ENSG00000183255
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.1
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110245
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.03
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: N/A
    Ensembl ID: ENSG00000164111
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Intestinal crypts are found at the base of the intestinal epithelium, and intestinal crypt stem cells are located within these crypts. 2. **Function**: Intestinal crypt stem cells are responsible for the proliferation and differentiation of intestinal epithelial cells, which form the lining of the intestine. 3. **Proliferation**: Intestinal crypt stem cells proliferate through mitotic division, allowing for the replacement of damaged or lost epithelial cells. 4. **Differentiation**: Intestinal crypt stem cells differentiate into various cell types, including columnar and goblet cells, which are essential for nutrient absorption and barrier function. 5. **Gene Expression**: Intestinal crypt stem cells express genes involved in cell proliferation, differentiation, and survival, including ACTB and B2M. 6. **Pathways/Ontology**: Intestinal crypt stem cells are involved in various cellular processes, including actin cytoskeleton organization, adherens junction assembly, and chromatin remodeling. **Clinical Significance** 1. **Intestinal Cancer**: Disruption of intestinal crypt stem cells has been implicated in the development of intestinal cancer, including colorectal cancer. 2. **Gastrointestinal Disorders**: Alterations in intestinal crypt stem cells have been linked to various gastrointestinal disorders, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 3. **Nutritional Deficiencies**: Impairment of intestinal crypt stem cells can lead to nutritional deficiencies, as these cells play a crucial role in the absorption of essential nutrients. 4. **Infectious Diseases**: Intestinal crypt stem cells are essential for the immune system's response to infectious diseases, such as bacterial and viral infections. 5. **Regenerative Medicine**: Understanding the biology of intestinal crypt stem cells has implications for the development of regenerative medicine strategies for the treatment of gastrointestinal disorders. In conclusion, the intestinal crypt stem cell is a critical cell type involved in maintaining the integrity and function of the intestinal epithelium. Disruption of these stem cells has been implicated in various gastrointestinal disorders and cancer. Further research is needed to fully understand the biology of intestinal crypt stem cells and their role in maintaining intestinal homeostasis.