Details for: CL0002258

Cell ID: CL0002258

Cell Name: thyroid follicular cell

Marker Score Threshold: 783
(Derived using integrated single-cell and genomic data)

Description: A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones.

Synonyms: follicular cell of thyroid gland, principal cell of thyroid gland, thyroid gland follicular cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 6.52
    Ensembl ID: ENSG00000120885
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 6.51
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 5.66
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.41
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 5.19
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 5.17
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.78
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 4.22
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.22
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 4.21
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 4.15
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 4.14
    Ensembl ID: ENSG00000105974
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 4.07
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.96
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.87
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.87
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.86
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.85
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 3.74
    Ensembl ID: ENSG00000168374
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 3.73
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.66
    Ensembl ID: ENSG00000185650
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 3.64
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.59
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.54
    Ensembl ID: ENSG00000135390
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 3.51
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 3.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 3.37
    Ensembl ID: ENSG00000124762
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 3.34
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.32
    Ensembl ID: ENSG00000165092
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.28
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.25
    Ensembl ID: ENSG00000143153
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.18
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 3.13
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 3.12
    Ensembl ID: ENSG00000162772
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.09
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 3.03
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.01
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.96
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 2.87
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.79
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.72
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 2.68
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.67
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.65
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.64
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.54
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CDH1 (ENSG00000039068)
    Fold Change: 2.42
    Ensembl ID: ENSG00000039068
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 2.32
    Ensembl ID: ENSG00000105971
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.29
    Ensembl ID: ENSG00000110955
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 2.28
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.24
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.18
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 2.18
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.14
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.11
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.98
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CKS2 (ENSG00000123975)
    Fold Change: 1.97
    Ensembl ID: ENSG00000123975
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.94
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.94
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.87
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.73
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CETN2 (ENSG00000147400)
    Fold Change: 1.67
    Ensembl ID: ENSG00000147400
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CLIC2 (ENSG00000155962)
    Fold Change: 1.63
    Ensembl ID: ENSG00000155962
  • Gene Symbol: CNN3 (ENSG00000117519)
    Fold Change: 1.62
    Ensembl ID: ENSG00000117519
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.61
    Ensembl ID: ENSG00000142188
  • Gene Symbol: CCNG2 (ENSG00000138764)
    Fold Change: 1.6
    Ensembl ID: ENSG00000138764
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.6
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.54
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.52
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.48
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.37
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.3
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.3
    Ensembl ID: ENSG00000175906
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.24
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.21
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.2
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BMP2 (ENSG00000125845)
    Fold Change: 1.17
    Ensembl ID: ENSG00000125845
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.17
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.15
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.14
    Ensembl ID: ENSG00000166165
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.14
    Ensembl ID: ENSG00000075239
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.14
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143149
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.12
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.11
    Ensembl ID: ENSG00000081181
  • Gene Symbol: CLN5 (ENSG00000102805)
    Fold Change: 1.11
    Ensembl ID: ENSG00000102805
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.08
    Ensembl ID: ENSG00000151729
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100852
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.06
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.06
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122705
Hovered Details

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Hovered Details

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**Key Characteristics** The thyroid follicular cell (CL0002258) exhibits several key characteristics that enable it to perform its primary function of thyroid hormone production and secretion. These characteristics include: 1. **Microvillus-directed luminal surface**: The cell's microvilli direct its luminal surface, allowing for the efficient secretion of thyroid hormones. 2. **Variable morphology**: The cell's morphology varies from squamous to columnar, depending on its activity. 3. **Thyroid hormone production and secretion**: The cell is responsible for synthesizing and secreting thyroid hormones, which are essential for regulating metabolism, growth, and development. 4. **Gene expression**: The cell's gene expression is regulated by various pathways, including those involved in amyloid-beta binding, antimicrobial peptides, and apical dendrite formation. **Clinical Significance** The thyroid follicular cell (CL0002258) plays a crucial role in thyroid function, and any disruptions in its function can lead to a range of clinical consequences. Some of the clinical significance of this cell type includes: 1. **Hypothyroidism**: Disruptions in thyroid hormone production and secretion can lead to hypothyroidism, a condition characterized by decreased thyroid hormone production. 2. **Hyperthyroidism**: Overproduction of thyroid hormones can lead to hyperthyroidism, a condition characterized by increased thyroid hormone production. 3. **Thyroid cancer**: Abnormalities in thyroid follicular cell function can lead to thyroid cancer, a type of cancer that affects the thyroid gland. 4. **Thyroiditis**: Inflammation of the thyroid gland can disrupt thyroid follicular cell function, leading to hypothyroidism or hyperthyroidism. In conclusion, the thyroid follicular cell (CL0002258) is a critical component of the thyroid gland, responsible for producing and secreting thyroid hormones. Understanding its function and clinical significance is essential for diagnosing and treating thyroid-related disorders.