Details for: CL0002262

Cell ID: CL0002262

Cell Name: endothelial cell of sinusoid

Marker Score Threshold: 243
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.7
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.5
    Ensembl ID: ENSG00000133639
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.4
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.35
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.15
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.14
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.13
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.1
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.07
    Ensembl ID: ENSG00000130303
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 2.04
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.93
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.91
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.91
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.9
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.88
    Ensembl ID: ENSG00000072110
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.86
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.86
    Ensembl ID: ENSG00000127022
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.79
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.79
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.78
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.76
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.73
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.67
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.67
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.66
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.65
    Ensembl ID: ENSG00000105974
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.64
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.62
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.6
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.59
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.59
    Ensembl ID: ENSG00000154518
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.59
    Ensembl ID: ENSG00000175899
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.59
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.58
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.57
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APLNR (ENSG00000134817)
    Fold Change: 1.54
    Ensembl ID: ENSG00000134817
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.53
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.52
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.51
    Ensembl ID: ENSG00000156273
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.49
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.47
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.46
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.45
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.45
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.45
    Ensembl ID: ENSG00000128595
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.42
    Ensembl ID: ENSG00000183255
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.41
    Ensembl ID: ENSG00000151914
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.39
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.39
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.37
    Ensembl ID: ENSG00000035687
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.35
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.31
    Ensembl ID: ENSG00000128272
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.29
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.28
    Ensembl ID: ENSG00000162909
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.26
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.25
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.21
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.2
    Ensembl ID: ENSG00000004455
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.2
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.2
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.2
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.19
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.18
    Ensembl ID: ENSG00000204217
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.16
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.15
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.13
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.1
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.1
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.1
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.08
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.07
    Ensembl ID: ENSG00000183020
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105971
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.06
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.05
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.03
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.03
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.02
    Ensembl ID: ENSG00000165527
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1
    Ensembl ID: ENSG00000090013
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1
    Ensembl ID: ENSG00000142599
Hovered Details

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Hovered Details

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**Key Characteristics** * Endothelial cells of sinusoids are specialized cells that line the venous cavities of various organs and glands. * The ACTB gene is involved in the regulation of: + Cell motility + Cytoskeleton organization + Cell-cell junctions * The ACTG1 gene is involved in the regulation of: + Angiogenesis + Cell-cell communication + Cytoskeleton organization * Both genes are involved in signaling pathways related to: + Immune responses + Cellular differentiation + Development * Endothelial cells of sinusoids play a crucial role in maintaining immune function, regulating blood flow, and controlling the exchange of nutrients and waste products. **Clinical Significance** * Endothelial dysfunction is a key factor in the development of various diseases, including atherosclerosis, hypertension, and diabetes. * The ACTB and ACTG1 genes may serve as potential therapeutic targets for the treatment of these diseases. * Endothelial cells of sinusoids may also play a role in the development of certain cancers, such as leukemia and lymphoma. * Further research is needed to fully understand the functions of endothelial cells of sinusoids and the role of the ACTB and ACTG1 genes in these cells. **Pathways/Ontology** * Actin cytoskeleton * Actin filament * Adherens junction * Adherens junction assembly * Adherens junctions interactions * Apical junction complex * Apical protein localization * Atp binding * Axon * Axon guidance * Axonogenesis * B-wich complex positively regulates rrna expression * Bbaf complex * Blood microparticle * Brahma complex * Brush border * Calyx of held * Cell-cell communication * Cell-cell junction * Cell-cell junction organization * Cell-extracellular matrix interactions * Cell junction organization * Cell motility * Cellular response to cytochalasin b * Chaperonin-mediated protein folding * Chromatin * Chromatin modifying enzymes * Chromatin organization * Chromatin remodeling * Clathrin-mediated endocytosis * Cooperation of prefoldin and tric/cct in actin and tubulin folding * Cortical cytoskeleton * Cytoplasm * Cytoplasmic ribonucleoprotein granule * Cytoskeleton * Cytosol * Dense body * Deubiquitination * Developmental biology * Disease * Diseases of signal transduction by growth factor receptors and second messengers * Dna damage recognition in gg-ner * Dna repair * Eph-ephrin mediated repulsion of cells * Eph-ephrin signaling * Ephb-mediated forward signaling * Extracellular exosome * Extracellular space * Fcgamma receptor (fcgr) dependent phagocytosis * Fcgr3a-mediated phagocytosis * Filamentous actin * Focal adhesion * Formation of annular gap junctions * Gap junction degradation * Gap junction trafficking * Gap junction trafficking and regulation * Gbaf complex * Gene expression (transcription) * Global genome nucleotide excision repair (gg-ner) * Glutamatergic synapse * Hats acetylate histones * Hemostasis * Hydrolase activity * Identical protein binding * Immune system * Infectious disease * Innate immune system * Interaction between l1 and ankyrins * Kinesin binding * Kinetochore * L1cam interactions * Lamellipodium * Leishmania infection * Leishmania phagocytosis * Maintenance of blood-brain barrier * Map2k and mapk activation * Mapk1/mapk3 signaling * Mapk family signaling cascades * Membrane * Membrane trafficking * Metabolism of proteins * Morphogenesis of a polarized epithelium * Nbaf complex * Negative regulation of cell differentiation * Negative regulation of protein binding * Nervous system development * Nitric-oxide synthase binding * Npbaf complex * Nua4 histone acetyltransferase complex * Nuclear matrix * Nucleoplasm * Nucleosomal dna binding * Nucleosome * Nucleotide excision repair * Nucleus * Oncogenic mapk signaling * Paradoxical activation of raf signaling by kinase inactive braf * Parasite infection * Parasitic infection pathways * Plasma membrane * Platelet aggregation * Positive epigenetic regulation of rrna expression * Positive regulation of cell differentiation * Positive regulation of cell population proliferation * Positive regulation of dna-templated transcription * Positive regulation of double-strand break repair * Positive regulation of double-strand break repair via homologous recombination * Positive regulation of myoblast differentiation * Positive regulation of norepinephrine uptake * Positive regulation of stem cell population maintenance * Positive regulation of t cell differentiation * Post-translational protein modification * Postsynaptic actin cytoskeleton * Postsynaptic actin cytoskeleton organization * Prefoldin mediated transfer of substrate to cct/tric * Presynapse * Protein-containing complex * Protein binding * Protein folding * Protein kinase binding * Protein localization to adherens junction * Raf/map kinase cascade * Recycling pathway of l1 * Regulation of actin dynamics for phagocytic cup formation * Regulation of apoptotic process * Regulation of cell cycle * Regulation of cyclin-dependent protein serine/threonine kinase activity * Regulation of double-strand break repair * Regulation of g0 to g1 transition * Regulation of g1/s transition of mitotic cell cycle * Regulation of mitotic metaphase/anaphase transition * Regulation of norepinephrine uptake * Regulation of nucleotide-excision repair * Regulation of protein localization to plasma membrane * Regulation of synaptic vesicle endocytosis * Regulation of transcription by rna polymerase ii * Regulation of transepithelial transport * Regulation of transmembrane transporter activity * Rhof gtpase cycle * Rho gtpase cycle * Rho gtpase effectors * Rho gtpases activate formins * Rho gtpases activate iqgaps * Rho gtpases activate wasps and waves * Ribonucleoprotein complex * Rsc-type complex * Schaffer collateral - ca1 synapse * Sensory perception * Sensory processing of sound * Sensory processing of sound by inner hair cells of the cochlea * Sensory processing of sound by outer hair cells of the cochlea * Signaling by braf and raf1 fusions * Signaling by high-kinase activity braf mutants * Signaling by moderate kinase activity braf mutants * Signaling by raf1 mutants * Signaling by ras mutants * Signaling by receptor tyrosine kinases * Signaling by rho gtpases * Signaling by rho gtpases, miro gtpases and rhobtb3 * Signaling by vegf * Signaling downstream of ras mutants * Signal transduction * Structural constituent of cytoskeleton * Structural constituent of postsynaptic actin cytoskeleton * Substantia nigra development * Swi/snf complex * Synapse * Tat protein binding * Tau protein binding * Tight junction * Translocation of slc2a4 (glut4) to the plasma membrane * Uch proteinases * Vegfa-vegfr2 pathway * Vesicle * Vesicle-mediated transport