Details for: CL0002275

Cell ID: CL0002275

Cell Name: pancreatic PP cell

Marker Score Threshold: 345
(Derived using integrated single-cell and genomic data)

Description: A PP cell located in the islets of the pancreas.

Synonyms: PP cell of pancreatic islet, PP-cell of pancreatic islet, pancreatic polypeptide-secreting cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.18
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.05
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.63
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.63
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.56
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.47
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.47
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.38
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.37
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.24
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.22
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.16
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.09
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.05
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.05
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2
    Ensembl ID: ENSG00000135940
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.91
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.9
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.89
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.85
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.85
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.8
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.76
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.75
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.74
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.71
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.7
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.69
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.68
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.65
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.63
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.59
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.56
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.55
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.55
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.53
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.49
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.47
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.44
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.43
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.41
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.41
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.38
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.35
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.31
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.31
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.29
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.29
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.27
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.27
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.26
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.24
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.24
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.21
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104763
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.17
    Ensembl ID: ENSG00000108561
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.16
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.16
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.16
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.14
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.13
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.13
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.11
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.1
    Ensembl ID: ENSG00000110651
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.1
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.07
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.07
    Ensembl ID: ENSG00000074201
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.07
    Ensembl ID: ENSG00000175416
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.06
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.05
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.05
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164615
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.02
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087274
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: PP cells are located in the islets of the pancreas. 2. **Function**: PP cells secrete pancreatic polypeptide (PP), a hormone involved in glucose and lipid metabolism. 3. **Gene expression**: PP cells express genes such as ACTB, which is involved in the regulation of cellular processes such as cell cycle progression and apoptosis. 4. **Pathways and ontology**: PP cells are involved in actin cytoskeleton, adherens junctions, and apical junction complex, indicating its role in maintaining cell-cell interactions and cytoskeletal organization. 5. **Synonyms**: PP cells are also known as PP cell of pancreatic islet, PP-cell of pancreatic islet, and pancreatic polypeptide-secreting cell. **Clinical Significance** 1. **Diabetes**: PP cells play a role in glucose metabolism, and alterations in PP secretion have been linked to diabetes. 2. **Pancreatic disorders**: PP cells are involved in the regulation of pancreatic function, and disorders affecting PP cells can lead to pancreatic dysfunction. 3. **Hormonal regulation**: PP cells are involved in the regulation of hormonal secretion, including insulin and glucagon, and alterations in PP secretion can affect glucose metabolism. 4. **Cellular signaling**: PP cells are involved in cellular signaling pathways, including those involved in cell growth, differentiation, and apoptosis. 5. **Disease models**: PP cells can be used as a model for studying diseases such as diabetes and pancreatic disorders, allowing for the investigation of the role of PP cells in disease pathogenesis. Overall, PP cells play a critical role in glucose and lipid metabolism, and alterations in PP secretion have been linked to various diseases. Further research is needed to fully understand the role of PP cells in disease pathogenesis and to develop effective therapeutic strategies for the treatment of PP-related disorders.