Details for: CL0002279

Cell ID: CL0002279

Cell Name: type L enteroendocrine cell

Marker Score Threshold: 273
(Derived using integrated single-cell and genomic data)

Description: A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.79
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.42
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.24
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.24
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.81
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.67
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.6
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.48
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.38
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.38
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.37
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.31
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.28
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.23
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.2
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.18
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.12
    Ensembl ID: ENSG00000122545
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.08
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.06
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.05
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.03
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.95
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.94
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.88
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.86
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.82
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.77
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.67
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.66
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.66
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.63
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.6
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.6
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.59
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.57
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.56
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.54
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.53
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.51
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.5
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.49
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.49
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.48
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.46
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.45
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.43
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.42
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.41
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.41
    Ensembl ID: ENSG00000162772
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.39
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.39
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.38
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.33
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.32
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.32
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.31
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.29
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.25
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.23
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.23
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.21
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.21
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.21
    Ensembl ID: ENSG00000026508
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.2
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.2
    Ensembl ID: ENSG00000126247
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.19
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.18
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.14
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.13
    Ensembl ID: ENSG00000124762
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.11
    Ensembl ID: ENSG00000198363
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.11
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.11
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.1
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.06
    Ensembl ID: ENSG00000162909
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.06
    Ensembl ID: ENSG00000010278
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.05
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143799
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.01
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1
    Ensembl ID: ENSG00000130303
Hovered Details

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Hovered Details

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**Key Characteristics** * **Location**: Enteroendocrine cells of type L are found in the ileum, jejunum, and large intestine, but are relatively rare in the duodenum. * **Function**: The primary function of these cells is to produce and secrete GLI and PYY, which play roles in regulating glucose metabolism, appetite, and satiety. * **Gene Expression**: The cell expresses a range of genes involved in hormone production and secretion, including those involved in protein folding, trafficking, and localization. * **Signaling Pathways**: The cell is responsive to a range of signaling pathways, including those involved in insulin and glucagon signaling, as well as those involved in the regulation of cell growth and differentiation. **Clinical Significance** * **Diabetes**: Alterations in the expression and secretion of GLI and PYY have been implicated in the pathogenesis of type 2 diabetes. * **Obesity**: Dysregulation of PYY secretion has been linked to obesity and metabolic disorders. * **Gastrointestinal Disorders**: Enteroendocrine cells play a role in regulating gastrointestinal motility and secretion, and alterations in their function can contribute to disorders such as irritable bowel syndrome (IBS) and gastroparesis. * **Cancer**: The cell's ability to produce and secrete hormones has been exploited in the development of certain types of cancer, including pancreatic neuroendocrine tumors. **Pathways/Ontology** The cell is involved in a range of signaling pathways and processes, including: * **Adaptive Immune System**: The cell is responsive to antigens and plays a role in regulating the adaptive immune response. * **Amyloid Fiber Formation**: The cell is involved in the production and secretion of amyloid proteins, which are implicated in a range of diseases, including Alzheimer's disease and amyloidosis. * **Antigen Presentation**: The cell plays a role in presenting antigens to T-cells, which is an important process in the regulation of the adaptive immune response. * **Cellular Response to Iron(III) Ion**: The cell is responsive to changes in iron ion concentration and plays a role in regulating iron homeostasis. * **Cytokine Signaling in Immune System**: The cell is involved in the regulation of cytokine signaling, which is an important process in the regulation of the immune response. Overall, the cell in question plays a critical role in regulating various physiological processes, including hormone secretion, immune response, and iron homeostasis. Its dysregulation has been implicated in a range of diseases, including diabetes, obesity, and cancer.