Details for: CL0002280

Cell ID: CL0002280

Cell Name: type N enteroendocrine cell

Marker Score Threshold: 412
(Derived using integrated single-cell and genomic data)

Description: An enteroendocrine cell found in the ileum and jejunum that produces neurotensin.

Synonyms: N cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.77
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.63
    Ensembl ID: ENSG00000156508
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.34
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.29
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.26
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.25
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.23
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.21
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.2
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.16
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.07
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.94
    Ensembl ID: ENSG00000133639
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.93
    Ensembl ID: ENSG00000114942
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.92
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.91
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.81
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.81
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.79
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.76
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.74
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.72
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.71
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.69
    Ensembl ID: ENSG00000077549
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.68
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.66
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.65
    Ensembl ID: ENSG00000111775
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.64
    Ensembl ID: ENSG00000120129
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.62
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.58
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.58
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.57
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.56
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.53
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.52
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.49
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.47
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.47
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.47
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.47
    Ensembl ID: ENSG00000051523
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.46
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.45
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.42
    Ensembl ID: ENSG00000172270
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.4
    Ensembl ID: ENSG00000131174
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.4
    Ensembl ID: ENSG00000129562
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.4
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.39
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152234
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.37
    Ensembl ID: ENSG00000215301
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.37
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.37
    Ensembl ID: ENSG00000127022
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.36
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.35
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.34
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.33
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.31
    Ensembl ID: ENSG00000122705
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.3
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.3
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.28
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.25
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.24
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.23
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.21
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.2
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.19
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.18
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.17
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.16
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.16
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.15
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.12
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.11
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.11
    Ensembl ID: ENSG00000168036
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.1
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.09
    Ensembl ID: ENSG00000117984
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.09
    Ensembl ID: ENSG00000084234
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.08
    Ensembl ID: ENSG00000128951
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.07
    Ensembl ID: ENSG00000042753
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197102
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.06
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.05
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.04
    Ensembl ID: ENSG00000146731
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.04
    Ensembl ID: ENSG00000053254
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.03
    Ensembl ID: ENSG00000110367
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.02
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ECH1 (ENSG00000104823)
    Fold Change: 1
    Ensembl ID: ENSG00000104823
Hovered Details

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Hovered Details

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**Key Characteristics** The Type N Enteroendocrine cell has several key characteristics, including: 1. **Production of Neurotensin**: These cells produce neurotensin, a neurotransmitter involved in various physiological processes, including pain modulation, mood regulation, and appetite control. 2. **Expression of ACTB Gene**: The cell expresses the ACTB gene, which encodes for beta-actin, a protein involved in the regulation of the actin cytoskeleton. 3. **Involvement in Actin Dynamics**: The cell plays a role in regulating actin dynamics, which is essential for cell motility, division, and signaling. 4. **Regulation of Cell Cycle**: The cell regulates the cell cycle, ensuring proper cell division and growth. 5. **Involvement in Apoptosis**: The cell is involved in the regulation of apoptosis, or programmed cell death, which is essential for maintaining tissue homeostasis. 6. **Role in Adaptive Immune System**: The cell plays a role in the adaptive immune system, including antigen presentation and cytokine signaling. 7. **Expression of B2M Gene**: The cell expresses the B2M gene, which encodes for beta-2 microglobulin, a protein involved in antigen presentation. **Clinical Significance** The Type N Enteroendocrine cell has several clinical significance, including: 1. **Involvement in Neurological Disorders**: The cell's production of neurotensin has been implicated in various neurological disorders, including pain modulation, mood regulation, and appetite control. 2. **Role in Cancer**: The cell's ability to regulate the cell cycle and apoptosis has been implicated in the development of cancer. 3. **Involvement in Immune System Disorders**: The cell's role in the adaptive immune system has been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency disorders. 4. **Potential Therapeutic Target**: The cell's production of neurotensin has been identified as a potential therapeutic target for various neurological and immunological disorders. In conclusion, the Type N Enteroendocrine cell is a complex cell with multiple functions, including the regulation of actin dynamics, cell cycle, and apoptosis, as well as its role in the adaptive immune system and antigen presentation. Its clinical significance is significant, with implications for neurological disorders, cancer, immune system disorders, and potential therapeutic targets.