Details for: CL0002303

Cell ID: CL0002303

Cell Name: pigmented ciliary epithelial cell

Marker Score Threshold: 340
(Derived using integrated single-cell and genomic data)

Description: A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions.

Synonyms: PE cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.14
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198691
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.77
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.74
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.6
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.46
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.32
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.26
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.18
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.16
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.1
    Ensembl ID: ENSG00000157388
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.05
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.02
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.94
    Ensembl ID: ENSG00000078295
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.91
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.84
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.81
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.81
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.79
    Ensembl ID: ENSG00000148700
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.74
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.73
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.73
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.7
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.67
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.64
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.64
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.6
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.59
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.59
    Ensembl ID: ENSG00000137845
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.58
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.55
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.54
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.54
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.51
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.49
    Ensembl ID: ENSG00000170634
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.48
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.47
    Ensembl ID: ENSG00000241837
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.47
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.45
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.42
    Ensembl ID: ENSG00000159842
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.39
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.39
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.38
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.37
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.37
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.36
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.36
    Ensembl ID: ENSG00000182389
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.33
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.33
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.3
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.28
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.28
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.27
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.27
    Ensembl ID: ENSG00000058668
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.26
    Ensembl ID: ENSG00000113916
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.26
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.24
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.24
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.23
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.21
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.19
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.17
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.16
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.12
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.11
    Ensembl ID: ENSG00000107779
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.11
    Ensembl ID: ENSG00000163697
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.11
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.1
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.1
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.1
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.08
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.06
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.06
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.05
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.04
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100823
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.04
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.02
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1
    Ensembl ID: ENSG00000278540
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Ion Transport**: The PE cell is capable of transporting sodium and chloride ions across the epithelial layer, which is essential for maintaining the proper ion balance and ensuring the proper functioning of the visual cycle. 2. **Gap Junctions**: The PE cell forms gap junctions with non-pigmented ciliary epithelial cells, allowing for the exchange of ions and other molecules between the two cell types. 3. **Visual Cycle**: The PE cell plays a crucial role in the maintenance of the visual cycle, which involves the regeneration of 11-cis retinal from 11-trans retinal. 4. **Actin Cytoskeleton**: The PE cell has a well-developed actin cytoskeleton, which is essential for maintaining cell shape and facilitating ion transport across the epithelial layer. 5. **Adherens Junctions**: The PE cell forms adherens junctions with non-pigmented ciliary epithelial cells, which helps to maintain cell-cell adhesion and regulate ion transport. **Clinical Significance** 1. **Visual Cycle Disorders**: Dysfunctions in the PE cell can lead to visual cycle disorders, such as retinitis pigmentosa and age-related macular degeneration. 2. **Ion Transport Disorders**: Abnormalities in ion transport across the epithelial layer can lead to a range of clinical disorders, including hypertension and hypokalemia. 3. **Ciliary Body Disease**: The PE cell is also involved in the regulation of ciliary body function, which is essential for maintaining proper intraocular pressure and preventing glaucoma. 4. **Ocular Development**: The PE cell plays a crucial role in the development of the eye, particularly during the formation of the visual cycle and the regulation of ion transport across the epithelial layer. In conclusion, the Pigmented Ciliary Epithelial Cell is a critical component of the visual cycle and ion transport across the epithelial layer. Dysfunctions in this cell type can lead to a range of clinical disorders, highlighting the importance of understanding its function and regulation.