Details for: CL0002304

Cell ID: CL0002304

Cell Name: non-pigmented ciliary epithelial cell

Marker Score Threshold: 292
(Derived using integrated single-cell and genomic data)

Description: A cell that is part of non-pigmented ciliary epithelium. This cell type participates in aqueous humor formation by releasing solute, principally sodium and chloride ions received from pigmented epithelial cells via gap junctions, into the aqueous humor of the eye.

Synonyms: NPE cell, nonpigmented ciliary epithelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 2.98
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 2.91
    Ensembl ID: ENSG00000198691
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.82
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2.82
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.78
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.77
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.72
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.68
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.62
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.62
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.61
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.58
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.5
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.47
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.36
    Ensembl ID: ENSG00000100852
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.28
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.24
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.19
    Ensembl ID: ENSG00000151150
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.05
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.04
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.04
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 2.03
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.02
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.99
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.98
    Ensembl ID: ENSG00000130402
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.92
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.91
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.89
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.85
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.84
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.72
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.68
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.67
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.65
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.61
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.59
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.55
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.55
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.54
    Ensembl ID: ENSG00000162104
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.54
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.53
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.53
    Ensembl ID: ENSG00000099624
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.5
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.48
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.46
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.46
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.45
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.45
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.45
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.45
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164904
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.41
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.37
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.33
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.32
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.31
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.3
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.26
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.26
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.25
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.2
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115170
  • Gene Symbol: BBS4 (ENSG00000140463)
    Fold Change: 1.2
    Ensembl ID: ENSG00000140463
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.16
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.15
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.14
    Ensembl ID: ENSG00000197381
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.14
    Ensembl ID: ENSG00000156273
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.13
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.12
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.11
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.11
    Ensembl ID: ENSG00000105552
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.1
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.1
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100412
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.08
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.08
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.07
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160710
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.03
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.01
    Ensembl ID: ENSG00000078295
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.01
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.01
    Ensembl ID: ENSG00000114573
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in non-pigmented ciliary epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in non-pigmented ciliary epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Cell type: Non-pigmented ciliary epithelial cell * Location: Non-pigmented ciliary epithelium of the eye * Function: Formation of aqueous humor through ion release into the aqueous humor * Gene symbols: RERE, ATP1A2, ABCA4, ADD3, BCKDHB, ANK2 * Pathways/ontology: Branching morphogenesis of a nerve, cerebellar granule cell precursor proliferation, cerebellar purkinje cell layer maturation, chromatin binding, chromatin remodeling, dendrite morphogenesis, histone deacetylase complex, metal ion binding, negative regulation of dna-templated transcription, nuclear body, nucleus, positive regulation of dna-templated transcription, protein binding, radial glia guided migration of purkinje cell, sequence-specific dna binding, transcription coactivator activity, transcription corepressor activity, ATPase-coupled monoatomic cation transmembrane transporter activity, ATP binding, ATP hydrolysis activity, ATP metabolic process, cellular response to mechanical stimulus, cellular response to steroid hormone stimulus, cytoplasm, dendritic spine, disease, endosome, infectious disease, intercalated disc, intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, ion channel transport, ion homeostasis, ion transport by p-type atpases, locomotion, locomotory exploration behavior, membrane, membrane depolarization during cardiac muscle cell action potential, membrane repolarization, monoatomic cation transmembrane transport, muscle contraction, negative regulation of calcium:sodium antiporter activity, negative regulation of calcium ion transmembrane transport, negative regulation of cytosolic calcium ion concentration, negative regulation of heart contraction, negative regulation of striated muscle contraction, neuronal cell body, neurotransmitter uptake, olfactory cortex development, organelle membrane, p-type sodium:potassium-exchanging transporter activity, phosphatase activity, plasma membrane, positive regulation of heart contraction, potassium ion binding, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, potential therapeutics for sars, protein-folding chaperone binding, protein binding, protein heterodimerization activity, proton transmembrane transport, regulation of blood pressure, regulation of cardiac muscle cell contraction, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of glutamate uptake involved in transmission of nerve impulse, regulation of muscle contraction, regulation of respiratory gaseous exchange by nervous system process, regulation of smooth muscle contraction, regulation of striated muscle contraction, regulation of synaptic transmission, glutamatergic, regulation of the force of heart contraction, regulation of vasoconstriction, relaxation of cardiac muscle, response to auditory stimulus, response to glycoside, response to nicotine, sars-cov infections, sodium:potassium-exchanging atpase complex, sodium ion binding, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport, steroid binding, steroid hormone binding, t-tubule, transport across blood-brain barrier, transport of small molecules, viral infection pathways, visual learning **Clinical Significance** Non-pigmented ciliary epithelial cells play a crucial role in maintaining the eye's pressure and overall health. Abnormalities in NPE cell function or number can lead to various eye disorders, including: * Glaucoma: A group of eye conditions that damage the optic nerve, often due to increased eye pressure. NPE cells can contribute to glaucoma by altering aqueous humor formation and dynamics. * Cataracts: A clouding of the lens in the eye that can lead to vision loss. NPE cells may play a role in the development of cataracts by regulating ion balance and aqueous humor formation. * Uveitis: Inflammation of the uvea, the middle layer of the eye. NPE cells can contribute to uveitis by releasing inflammatory mediators and altering aqueous humor dynamics. Understanding the function and regulation of NPE cells is essential for developing effective treatments for these eye disorders.