Details for: CL0002306

Cell ID: CL0002306

Cell Name: epithelial cell of proximal tubule

Marker Score Threshold: 3551
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the proximal tubule of the kidney.

Synonyms: kidney proximal tubule epithelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.36
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.12
    Ensembl ID: ENSG00000124172
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 3.97
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.82
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.65
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 3.57
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.45
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 3.32
    Ensembl ID: ENSG00000177556
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.11
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 3.03
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 2.96
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.82
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.81
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.75
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.71
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.7
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 2.67
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 2.64
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.62
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.56
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.55
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 2.54
    Ensembl ID: ENSG00000240583
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.49
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.48
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.45
    Ensembl ID: ENSG00000155366
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.44
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.43
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 2.4
    Ensembl ID: ENSG00000060971
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.4
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.38
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.35
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.32
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.24
    Ensembl ID: ENSG00000145362
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.21
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 2.19
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 2.18
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 2.16
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.15
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.1
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.08
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.01
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.88
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.87
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.86
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.86
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.85
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.83
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.8
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.79
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.79
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.74
    Ensembl ID: ENSG00000100412
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.72
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122729
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.71
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.66
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.66
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.64
    Ensembl ID: ENSG00000100852
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.62
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.62
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.59
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.47
    Ensembl ID: ENSG00000164904
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.44
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.43
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.41
    Ensembl ID: ENSG00000110330
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.41
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138175
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.4
    Ensembl ID: ENSG00000006125
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.37
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.31
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.3
    Ensembl ID: ENSG00000120805
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.25
    Ensembl ID: ENSG00000079557
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.25
    Ensembl ID: ENSG00000170017
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 1.24
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.24
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.22
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.21
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.18
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.18
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.18
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.18
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.17
    Ensembl ID: ENSG00000131473
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.16
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ABCC6 (ENSG00000091262)
    Fold Change: 1.15
    Ensembl ID: ENSG00000091262
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.14
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 1.11
    Ensembl ID: ENSG00000108381
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.11
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115170
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.02
    Ensembl ID: ENSG00000135046
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.01
    Ensembl ID: ENSG00000102575
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Proximal tubule of the kidney 2. **Cell Type**: Epithelial cell 3. **Gene Expression**: Regulated by multiple pathways, including actin dynamics, cell signaling, and epigenetic modifications 4. **Cytoskeletal Organization**: Actin cytoskeleton plays a crucial role in maintaining cell shape and facilitating cell motility 5. **Cell-Cell Communication**: Epithelial cells in the proximal tubule communicate with each other through adherens junctions and gap junctions 6. **Regulation of Filamentous Actin**: The cell's filamentous actin is regulated by various proteins, including actin-binding proteins and actin-modulating proteins 7. **Involvement in Metabolic Processes**: The cell is involved in the reabsorption of essential nutrients and ions from the filtrate **Clinical Significance** 1. **Renal Disease**: Dysfunction of the proximal tubular epithelial cells can lead to various renal diseases, including diabetic nephropathy, chronic kidney disease, and acute kidney injury 2. **Nutrient Reabsorption**: The proximal tubular epithelial cells play a crucial role in the reabsorption of essential nutrients, including glucose, amino acids, and ions, which are critical for maintaining proper bodily functions 3. **Ion Homeostasis**: The cell's ability to regulate ion homeostasis is essential for maintaining proper blood pressure and preventing electrolyte imbalances 4. **Cancer**: Alterations in the gene expression of the proximal tubular epithelial cells have been implicated in the development of certain types of cancer, including renal cell carcinoma 5. **Infectious Diseases**: The cell's involvement in immune responses and its ability to regulate cell-cell communication make it an important target for the study of infectious diseases, including those caused by viruses and bacteria. In summary, the epithelial cell of the proximal tubule of the kidney is a complex cell type that plays a critical role in maintaining renal function, regulating nutrient reabsorption, and responding to infectious diseases. Further research on this cell type is essential for understanding the molecular mechanisms underlying renal disease and developing effective therapeutic strategies.